Insight into the antibacterial mechanism of Cu-enriched sol–gel coatings employing proteomics

Romero‐Gavilán, Francisco; García‐Arnáez, Iñaki; Cerqueira, Andreia; Scalschi, Loredana; Vicedo, Begonya; Villagrasa, Alejandro; Escrig, R. Izquierdo; Azkargorta, Mikel; Elortza, Félix; Gurruchaga, M.; Goñi, Isabel; Suay, J.

doi:10.1039/d2bm01421a

Cited by 3 publications

(1 citation statement)

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“…This establishes an inflammatory microenvironment conducive to osteogenesis and heightened infection resistance (Figure 8). 130 A study by Romero‐Gavilan et al 131 has revealed that Cu 2+ supplementation influences the adsorption of proteins associated with complement, angiogenesis, and osteogenesis on material surfaces. Such an interaction bolsters both bactericidal and osteogenic properties.…”

Section: Bone Biomaterials Modified By Inorganic Active Ionsmentioning

confidence: 99%

Ion incorporation into bone grafting materials

Zhao,

Ni,

Wei

et al. 2023

Periodontology 2000

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The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease in orthopedics and dentistry. However, the treatment of large and complex bone defects presents a challenge, leading to a pressing need for optimized biomaterials for bone repair. Recent advances in chemical sciences have enabled the incorporation of therapeutic ions into bone grafts to enhance their performance. These ions, such as strontium (for bone regeneration/osteoporosis), copper (for angiogenesis), boron (for bone growth), iron (for chemotaxis), cobalt (for B12 synthesis), lithium (for osteogenesis/cementogenesis), silver (for antibacterial resistance), and magnesium (for bone and cartilage regeneration), among others (e.g., zinc, sodium, and silica), have been studied extensively. This review aims to provide a comprehensive overview of current knowledge and recent developments in ion incorporation into biomaterials for bone and periodontal tissue repair. It also discusses recently developed biomaterials from a basic design and clinical application perspective. Additionally, the review highlights the importance of precise ion introduction into biomaterials to address existing limitations and challenges in combination therapies. Future prospects and opportunities for the development and optimization of biomaterials for bone tissue engineering are emphasized.

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Section: Bone Biomaterials Modified By Inorganic Active Ionsmentioning

confidence: 99%