Insight into the behavior regulation of drug transfer of nimodipine loaded PLGA microspheres by emulsion evaporation method

Yang, Qingqing; Bian, Yizhen; Hong, Minghuang

doi:10.1016/j.colsurfa.2023.131569

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…The particle size of PLGA NPs produced through emulsificationsolvent evaporation is influenced by various factors, such as the emulsifier type and the volume ratio between the organic and aqueous phases [7,8]. Indeed, its primary determinants are the characteristics of the emulsion droplets [9][10][11][12]. Surfactants, such as bovine serum albumin (BSA) [13] and polyvinyl alcohol (PVA) [14,15], are incorporated into the continuous phase to inhibit the polymerization of emulsion droplets.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Different Factors on Poly(lactic-co-glycolic acid) Nanoparticle Properties and Drug Release Behaviors When Co-Loaded with Hydrophilic and Hydrophobic Drugs

Wang,

Liu

et al. 2024

Polymers

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Poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) are versatile drug nanocarriers with a wide spectrum of applications owing to their extensive advantages, including biodegradability, non-toxic side effects, and low immunogenicity. Among the numerous nanoparticle preparation methods available for PLGA NPs (the hydrophobic polymer), one of the most extensively utilized preparations is the sonicated-emulsified solvent evaporation method, owing to its simplicity, speed, convenience, and cost-effectiveness. Nevertheless, several factors can influence the outcomes, such as the types of concentration of the surfactants and organic solvents, as well as the volume of the aqueous phase. The objective of this article is to explore the influence of these factors on the properties of PLGA NPs and their drug release behavior following encapsulation. Herein, PLGA NPs were fabricated using bovine serum albumin (BSA) as a surfactant to investigate the impact of influencing factors, including different water-soluble organic solvents such as propylene carbonate (PC), ethyl acetate (PA), and dichloromethane (DCM). Notably, the size of PLGA NPs was smaller in the EA group compared to that in the DCM group. Moreover, PLGA NPs showed excellent stability, ascribed to the presence of the BSA surfactant. Furthermore, PLGA NPs were co-loaded with varying concentrations of hydrophilic drugs (doxorubicin hydrochloride) and hydrophobic drugs (celecoxib), and exhibited pH-sensitive drug release behavior in PBS with pH 7.4 and pH 5.5.

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Section: Introductionmentioning

confidence: 99%

The Effect of Different Factors on Poly(lactic-co-glycolic acid) Nanoparticle Properties and Drug Release Behaviors When Co-Loaded with Hydrophilic and Hydrophobic Drugs

Wang,

Liu

et al. 2024

Polymers

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Quantification of Microsphere Drug Release by Fluorescence Imaging with the FRET System

Chen,

Lu,

et al. 2024

Pharmaceutics

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Accurately measuring drug and its release kinetics in both in vitro and in vivo environments is crucial for enhancing therapeutic effectiveness while minimizing potential side effects. Nevertheless, the real-time visualization of drug release from microspheres to monitor potential overdoses remains a challenge. The primary objective of this investigation was to employ fluorescence imaging for the real-time monitoring of drug release from microspheres in vitro, thereby simplifying the laborious analysis associated with the detection of drug release. Two distinct varieties of microspheres were fabricated, each encapsulating different drugs within PLGA polymers. Cy5 was selected as the donor, and Cy7 was selected as the acceptor for visualization and quantification of the facilitated microsphere drug release through the application of the fluorescence resonance energy transfer (FRET) principle. The findings from the in vitro experiments indicate a correlation between the FRET fluorescence alterations and the drug release profiles of the microspheres.

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Insight into the behavior regulation of drug transfer of nimodipine loaded PLGA microspheres by emulsion evaporation method

Cited by 2 publications

References 26 publications

The Effect of Different Factors on Poly(lactic-co-glycolic acid) Nanoparticle Properties and Drug Release Behaviors When Co-Loaded with Hydrophilic and Hydrophobic Drugs

The Effect of Different Factors on Poly(lactic-co-glycolic acid) Nanoparticle Properties and Drug Release Behaviors When Co-Loaded with Hydrophilic and Hydrophobic Drugs

Quantification of Microsphere Drug Release by Fluorescence Imaging with the FRET System

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