Insight into the biological pathways underlying fibromyalgia by a proteomic approach

Ramírez-Tejero, Jorge A.; Martı́nez-Lara, Esther; Rus, Alma; Camacho, María Victoria Galloso; Moral, Marı́a Luisa Del; Siles, Eva

doi:10.1016/j.jprot.2018.07.009

Cited by 49 publications

(67 citation statements)

References 45 publications

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“…ESR is an acute phase reagent; that is, a nonspecific marker whose elevation may involve inflammatory processes. Data by our research group showed elevated ESR values in patients with FM in comparison to healthy subjects [29], and consumption of both olive oils approximates values of patients with FM to those of healthy subjects (data from healthy subjects can be consulted at Ramírez-Tejero et al, 2018 [29]). Several authors did not find significant changes in ESR after consumption of EVOO in comparison to ROO in HIV-infected patients.…”

Section: Discussionmentioning

confidence: 80%

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

et al. 2020

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We have recently reported that patients with fibromyalgia (FM) may be at increased risk for cardiovascular disease. Olive oil reportedly has cardioprotective effects. We examined the influence of olive oil consumption on cardiovascular risk factors in FM. This preliminary study was performed on blood samples of women with FM who consumed 50 mL of organic olive oil daily for 3 weeks. Patients were randomized into two groups: 15 women ingested extra virgin olive oil (EVOO) and 15 refined olive oil (ROO). Cardiovascular risk markers were measured at baseline (pre measure) and after consumption of olive oil (post measure). Red blood cell count and erythrocyte sedimentation rate (ESR; both p < 0.05) declined significantly post-treatment in the EVOO group. Consumption of ROO increased mean platelet volume and reduced platelet distribution width (PDW), neutrophil-to-lymphocyte ratio, ESR and fibrinogen (all p < 0.05). Significant differences were found in pre–post change between the EVOO and ROO groups for cortisol and PDW (both p < 0.05). Our results have shown that consumption of olive oil may have antithrombotic and antiinflammatory properties in patients with FM, thereby improving a number of cardiovascular risk markers. Both EVOO and ROO may be useful as adjuvants for the prevention and/or treatment of cardiovascular disorders in these patients.

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Section: Discussionmentioning

confidence: 80%

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

et al. 2020

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“…The PPI enrichment analysis of altered proteins in plasma from CWP/FM compared to controls was highly significant [48,86,87], a finding that indicates the proteins were at least partially biologically connected as two large groups (clusters I and II) ( Figure 4). Cluster I was dominated by proteins involved in post-translational modifications and in regulation of cellular protein metabolic processes.…”

Section: Blood Proteins In Fibromyalgia -Network Analysismentioning

confidence: 99%

“…Finally, Ramirez-Tejero et al found a total of 33 proteins differentially expressed in FM compared to controls [48]. Using a network analysis, the authors concluded that the different biological pathways involved in the identified protein profile were related to inflammation.…”

Section: Cwp/fm -Bloodmentioning

confidence: 99%

“…Both Wåhlén et al and Ramirez-Tejero et al found that haptoglobin, serotransferrin, fibrinogen gamma chain, and the protein complement C1s subcomponent were altered [48,87]. Furthermore, both Wåhlén et al and Ruggero et al found that transthyretin was altered [86,87].…”

Section: Cwp/fm -Bloodmentioning

confidence: 99%

“…Furthermore, available data suggest that chronic pain is a complex process involving interactions of an array of biochemical, transmitters, and receptors both in the central and peripheral nervous systems. It is highly unlikely that conditions such as chronic pain and cancer can be captured in their entirety by one biomarker as these conditions are heterogenous and the result of interacting complex cellular networks [48,49]. To date, no unidimensional reliable biomarker for pain has been identified.…”

Section: Single Molecules In Blood and Csf -Drawbacksmentioning

confidence: 99%

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Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses

Gerdle

Ghafouri

2020

Expert Review of Proteomics

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Introduction: The lack of biomarkers indicating involved nociceptive and/or pain mechanisms makes diagnostic procedures problematic. Clinical pain research has begun to use proteomics. Areas covered: This systematic review covers proteomic studies of chronic pain cohorts and in relation to clinical variables. Searches in three databases identified 96 studies from PubMed, 161 from Scopus and 155 from Web of Science database. Finally, 27 relevant articles were included. Network analyses based on the identified proteins were performed. Expert opinion: Small pain cohorts were investigated and the number of studies per diagnosis and tissue is small. The use of proteomics in chronic pain research is exploratory and larger proteomic studies are needed. It will be necessary to standardize the descriptions of the pain cohorts investigated. There is a need to identify the mechanisms underlying the whole clinical presentation of specific chronic pain conditions. Multivariate methods capable of handling and identifying intercorrelated protein patterns must be applied. Rather than focusing on a few proteins, future studies should use network analyses to investigate interactions and biological processes. Proteomics in combination with bioinformatics have a huge potential to identify previously unknown panels of proteins involved in chronic pain and relevant when devising new pain control strategies.

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Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia

Hsu

Han

et al. 2021

European Journal of Pain

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Background: Fibromyalgia (FM) is characterized by chronic widespread pain.Its pathophysiological mechanisms remain poorly understood, and effective diagnosis and treatments are lacking. This study aimed to identify significantly changed biosignatures in FM and propose a novel classification for FM based on pain and soreness (sng) symptoms.Methods: Urine and serum samples from 30 FM patients and 25 controls underwent metabolomic and proteomic profiling.Results: Compared with controls, FM patients showed significant differential expression of three metabolites in urine and five metabolites and eight proteins in serum. Of them, DETP, 4-guanidinobutanoic acid, SM(d18:1/18:0), PC(20:1(11Z)/18:0), S100A7, SERPINB3, galectin-7 and LYVE1 were first reported as potential biomarkers for FM. Furthermore, lactate, 2-methylmaleate and cotinine in urine and lactate, SM(d18:1/25:1), SM(d18:1/26:1) and prostaglandin D2 (PGD2) and PCYOX1, ITIH4, PFN1, LRG1, C8G, C8A, CP, CDH5 and DBH in serum could differentiate pain-(PG) and sng-dominant groups (SG). Lactate, 2-methylmaleate, cotinine, PCYOX1, ITIH4, PFN1 and DBH have a higher level in SG. SM(d18:1/25:1), SM(d18:1/26:1), PGD2, LRG1, C8G, C8A, CP and CDH5 in SG are lower than PG. The omics results indicated disordered free radical scavenging,This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Insight into the biological pathways underlying fibromyalgia by a proteomic approach

Cited by 49 publications

References 45 publications

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses

Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia

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