Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China

Fu, Xinliang; Hou, Zhanpeng; Liu, Wenjun; Cao, Nan; Liang, Yu; Li, Bingxin; Jiang, Danli; Li, Wanyan; Xu, Danning; Tian, Yunbo; Huang, Yunmao

doi:10.3390/v14061306

Cited by 10 publications

(5 citation statements)

References 31 publications

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“…Transmission electron microscopy shows a star-like protrusion on its surface ( Shen et al, 2022 ). The genome of goose astrovirus consists of a 5′-untranslated region (5′ -UTR), three open reading frames (ORF1a, ORF1b and ORF2), 3′-untranslated region (3’-UTR) and poly (A) Tail ( Fu et al, 2022 ). The length of goose astrovirus genome varies by species.…”

Section: Viral Genome Characteristics and Viral Protein Functionmentioning

confidence: 99%

Infection and innate immune mechanism of goose astrovirus

Jiang

Cheng

et al. 2023

Front. Microbiol.

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Goose astrovirus (GAstV, genus Avian Astrovirus, family Astrovirus) was first discovered in 2005, but was not considered as a pathogen of gosling gout until 2016. Since then, goose astrovirus has erupted in Chinese goslings, causing at most 50% of gosling deaths. By December 2022, the disease had become epidemic and prevailed in goose farms in Jiangsu, Shandong, Anhui, Henan, Guangdong, Liaoning, Sichuan and other places in China. The disease mainly affects goslings within 3 weeks old. The typical symptoms of goose astrovirus are large deposits of urate in the viscera, joint cavity and ureter surface of infected goslings. Goose astrovirus infection can trigger high levels of iNOS, limiting goose astrovirus replication. The ORF2 domain P2 of the goose astrovirus activates the OASL protein, limiting its replication. Goose astrovirus can also activate pattern recognition receptors (RIG-I, MDA-5, TLR-3), causing an increase in MHC-Ia, MHC-Ib and CD81 mRNA, activating humoral and cellular immunity, thereby hindering virus invasion. Goose astrovirus also regulates the activation of IFNs and other antiviral proteins (Mx1, IFITM3, and PKR) in the spleens and kidneys to inhibit viral replication. The innate immune response process in goslings also activates TGF-β, which may be closely related to the immune escape of goose astrovirus. Gaining insight into the infection and innate immune mechanism of goose astrovirus can help researchers study and prevent the severe disease in goslings better.

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Section: Viral Genome Characteristics and Viral Protein Functionmentioning

confidence: 99%

Infection and innate immune mechanism of goose astrovirus

Jiang

Cheng

et al. 2023

Front. Microbiol.

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“…In accordance with this viral classification criterion, GAstV can be divided into two distinct genotypes: GAstV genotype-1 and GAstV genotype-2. Moreover, there are significant differences in strains characteristics between these two genotypes (Niu et al, 2018;Fu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Viral emerging and re-emerging diseases: Basic understanding and future intervention strategies

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Introductionmentioning

confidence: 99%

Molecular epidemiology and virulence of goose astroviruses genotype-2 with different internal gene sequences

Xu,

Jiang,

Cheng

et al. 2023

Front. Microbiol.

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Goose astrovirus (GAstV) is a small, non-enveloped, single-stranded, positive-sense RNA virus. GAstV has rapidly spread across various regions in China since 2016. In Sichuan, out of 113 samples were collected from goose diseases between 2019 and 2022, 97 were positive for GAstV through PCR testing. Remarkably, over the past three years, GAstV outbreak in Sichuan has accounted for an astonishing 85.8% of all goose-origin viruses. Among these cases, 63.9% had single GAstV infections, 29.9% had dual infections, and 6.2% had quadruple infections. To comprehend the variations in virulence among distinct strains of GAstV. 12 representative strains of single GAstV infections were isolated. These strains exhibited distinct characteristics, such as prominent white urate depositions in organs and joints, as well as extensive tissues phagocytosis in major target organs’ tissues. The conserved ORF1b genes and the variable ORF2 genes of these representative GAstV strains were sequenced, enabling the establishment of phylogenetic trees for GAstV. All GAstV strains were identified as belonging to genotype-2 with varying internal gene sequences. Experiments were conducted on GAstV genotype-2, both in vivo and in vitro, revealed significant variations in pathogenicity and virulence across susceptible cells, embryos, and goslings. This comprehensive study enhances researchers’ understanding of the transmission characteristics and virulence of GAstV genotype-2, aiding in a better comprehension of their molecular epidemiology and pathogenic mechanism.

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Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China

Cited by 10 publications

References 31 publications

Infection and innate immune mechanism of goose astrovirus

Infection and innate immune mechanism of goose astrovirus

Viral emerging and re-emerging diseases: Basic understanding and future intervention strategies

Molecular epidemiology and virulence of goose astroviruses genotype-2 with different internal gene sequences

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