2006
DOI: 10.1002/cbf.1378
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Insight into the free‐radical‐scavenging mechanism of hydroxyl‐substituent Schiff bases in the free‐radical‐induced hemolysis of erythrocytes

Abstract: This work aimed to explore the mechanism by which hydroxyl-substituent Schiff bases scavenge free-radicals. Thus, four Schiff bases, that is benzylidene aniline (BAN), 2-(phenyliminomethyl)phenol (BAH), 4-benzimidoylphenol (PBH) and 2-benzimidoylphenol (OBH), were applied to protect human erythrocytes against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH)-induced hemolysis. The results revealed that the --OH attached to the ortho-position of methylene in Schiff base scavenges 1.46 radicals per molecule, th… Show more

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Cited by 8 publications
(9 citation statements)
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“…The lag time, t lag , is prolonged proportionally with different concentrations of Schiff bases added. In order to emphasize the influence of Schiff bases on t lag , the difference between t lag and t lag0 is defined as t inh to reveal the protective effect of Schiff bases themselves on erythrocytes, 10,11 and listed in Table 1. Based on the relationship of t inh ¼ (n/R i ) [AH], the correlation of the concentrations of Schiff bases with the t inh can be found in Table 2, together with the plots of the equations illustrated in Figure 2.…”
Section: Resultsmentioning
confidence: 99%
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“…The lag time, t lag , is prolonged proportionally with different concentrations of Schiff bases added. In order to emphasize the influence of Schiff bases on t lag , the difference between t lag and t lag0 is defined as t inh to reveal the protective effect of Schiff bases themselves on erythrocytes, 10,11 and listed in Table 1. Based on the relationship of t inh ¼ (n/R i ) [AH], the correlation of the concentrations of Schiff bases with the t inh can be found in Table 2, together with the plots of the equations illustrated in Figure 2.…”
Section: Resultsmentioning
confidence: 99%
“…The t lag0 is prolonged by the addition of PAH, assigned as t lag . Thus, the difference between t lag and t lag0 , t inh ¼ t lag Àt lag0 , reveals the contribution from the addition of PAH whose concen- antioxidative effects of schiff bases on hemolysishemolysis, 11 thus, the n of the OH attached to the para position of methylene in PIH can be assigned to the difference of n between PIH and BAN (6.00À4.67 ¼ 1.33).…”
Section: Discussionmentioning
confidence: 99%
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