Insight into the Impact of Oxidative Stress on the Barrier Properties of Lipid Bilayer Models

Nasri, Zahra; Ahmadi, Mohsen; Striesow, Johanna; Ravandeh, Mehdi; Woedtke, Thomas von; Wende, Kristian

doi:10.3390/ijms23115932

Cited by 14 publications

(11 citation statements)

References 79 publications

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“…The oxidative degradation of FenD was monitored using high-resolution ESI-MS(–) ( Figure A9 ). Polyene unsaturated double bonds underwent reactions in the presence of • O and • OH (hydroxylation and dihydroxylation), • OOH and O 2 (epoxidation), and 1 O 2 (to form allylic hydroperoxides) [ 19 , 61 , 66 ]. Both FenH ( m/z 418.25) and FenD ( m/z 390.24) were oxidized with longer plasma treatment (>20 s).…”

Section: Resultsmentioning

confidence: 99%

Cold Physical Plasma-Mediated Fenretinide Prodrug Activation Confers Additive Cytotoxicity in Epithelial Cells

et al. 2023

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Cold physical plasma is a partially ionized gas operated at body temperature and utilized for heat-sensitive technical and medical purposes. Physical plasma is a multi-component system consisting of, e.g., reactive species, ions and electrons, electric fields, and UV light. Therefore, cold plasma technology is an interesting tool for introducing biomolecule oxidative modifications. This concept can be extended to anticancer drugs, including prodrugs, which could be activated in situ to enhance local anticancer effects. To this end, we performed a proof-of-concept study on the oxidative prodrug activation of a tailor-made boronic pinacol ester fenretinide treated with the atmospheric pressure argon plasma jet kINPen operated with either argon, argon–hydrogen, or argon–oxygen feed gas. Fenretinide release from the prodrug was triggered via Baeyer–Villiger-type oxidation of the boron–carbon bond based on hydrogen peroxide and peroxynitrite, which were generated by plasma processes and chemical addition using mass spectrometry. Fenretinide activation led to additive cytotoxic effects in three epithelial cell lines in vitro compared to the effects of cold plasma treatment alone regarding metabolic activity reduction and an increase in terminal cell death, suggesting that cold physical plasma-mediated prodrug activation is a new direction for combination cancer treatment studies.

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Section: Resultsmentioning

confidence: 99%

Cold Physical Plasma-Mediated Fenretinide Prodrug Activation Confers Additive Cytotoxicity in Epithelial Cells

et al. 2023

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“…The alteration of plasma phospholipid levels 2 weeks after completion of doxorubicin treatment exhibited different patterns between HER2-positive and HER2-negative breast cancer patients. Since systemic oxidative stress leads to the modification of phospholipids [ 53 – 55 ], the different patterns of plasma phospholipid changes between these two groups of patients were likely due to the different changes in systemic oxidative stress. Interestingly, we found a strong correlation between the decrease in plasma phosphatidylglycerol levels and an increase in LF/HF ratio 2 weeks after completion of doxorubicin treatment in HER2-negative breast cancer patients, suggesting a critical role of phosphatidylglycerol in the regulation of heart rate variability.…”

Section: Discussionmentioning

confidence: 99%

Changes in blood metabolomes as potential markers for severity and prognosis in doxorubicin-induced cardiotoxicity: a study in HER2-positive and HER2-negative breast cancer patients

Thonusin,

Osataphan,

Leemasawat

et al. 2024

J Transl Med

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Background We aimed to compare the changes in blood metabolomes and cardiac parameters following doxorubicin treatment in HER2-positive and HER2-negative breast cancer patients. Additionally, the potential roles of changes in blood metabolomes as severity and prognostic markers of doxorubicin-induced cardiotoxicity were determined. Methods HER2-positive (n = 37) and HER2-negative (n = 37) breast cancer patients were enrolled. Cardiac function assessment and blood collection were performed at baseline and 2 weeks after completion of doxorubicin treatment in all patients, as well as at three months after completion of doxorubicin treatment in HER2-negative breast cancer patients. Blood obtained at all three-time points was processed for measuring cardiac injury biomarkers. Blood obtained at baseline and 2 weeks after completion of doxorubicin treatment were also processed for measuring systemic oxidative stress and 85 metabolome levels. Results Cardiac injury and systolic dysfunction 2 weeks after completion of doxorubicin treatment were comparable between these two groups of patients. However, only HER2-negative breast cancer patients exhibited increased systemic oxidative stress and cardiac autonomic dysfunction at this time point. Moreover, 33 and 29 blood metabolomes were altered at 2 weeks after completion of doxorubicin treatment in HER2-positive and HER2-negative breast cancer patients, respectively. The changes in most of these metabolomes were correlated with the changes in cardiac parameters, both at 2 weeks and 3 months after completion of doxorubicin treatment. Conclusions The changes in blood metabolomes following doxorubicin treatment were dependent on HER2 status, and these changes might serve as severity and prognostic markers of doxorubicin-induced cardiotoxicity. Trial registration: The study was conducted under ethical approval from the Institutional Review Board of the Faculty of Medicine, Chiang Mai University (Registration number: MED-2563-07001; Date: April 28, 2020). The study also complied with the Declaration of Helsinki.

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“…Changes in altitude will alter the accumulation of secondary metabolites in plant tissues, thereby adjusting the adaptability of plants to environmental changes [53]. The increase of reactive oxygen species in high-altitude areas can damage the cell membrane system, resulting in abnormal metabolism, and even cell death [36,54]. The antioxidant activity of medicinal plants is commonly evaluated by the scavenging rate of DPPH radicals and ABTS radicals [55].…”

Section: Discussionmentioning

confidence: 99%

Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal Plant Asarum

Pan,

Yang,

Sui

et al. 2023

Metabolites

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Asarum (Asarum sieboldii Miq. f. seoulense (Nakai) C. Y. Cheng et C. S. Yang) is a medicinal plant that contains asarinin and sesamin, which possess extensive medicinal value. The adaptation and distribution of Asarum’s plant growth are significantly affected by altitude. Although most studies on Asarum have concentrated on its pharmacological activities, little is known about its growth and metabolites with respect to altitude. In this study, the physiology, ionomics, and metabolomics were investigated and conducted on the leaves and roots of Asarum along an altitude gradient, and the content of its medicinal components was determined. The results showed that soil pH and temperature both decreased along the altitude, which restricts the growth of Asarum. The accumulation of TOC, Cu, Mg, and other mineral elements enhanced the photosynthetic capacity and leaf plasticity of Asarum in high-altitude areas. A metabolomics analysis revealed that, at high altitude, nitrogen metabolism in leaves was enhanced, while carbon metabolism in roots was enhanced. Furthermore, the metabolic pathways of some phenolic substances, including syringic acid, vanillic acid, and ferulic acid, were altered to enhance the metabolism of organic acids. The study uncovered the growth and metabolic responses of Asarum to varying altitudes, providing a theoretical foundation for the utilization and cultivation of Asarum.

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Insight into the Impact of Oxidative Stress on the Barrier Properties of Lipid Bilayer Models

Cited by 14 publications

References 79 publications

Cold Physical Plasma-Mediated Fenretinide Prodrug Activation Confers Additive Cytotoxicity in Epithelial Cells

Cold Physical Plasma-Mediated Fenretinide Prodrug Activation Confers Additive Cytotoxicity in Epithelial Cells

Changes in blood metabolomes as potential markers for severity and prognosis in doxorubicin-induced cardiotoxicity: a study in HER2-positive and HER2-negative breast cancer patients

Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal Plant Asarum

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