Multidimensional Flow Cytometry Techniques for Novel Highly Informative Assays 2018
DOI: 10.5772/intechopen.76481
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Insight into the Leukemia Microenvironment and Cell-cell Interactions Using Flow Cytometry

Abstract: Cancer cells, including leukemia cells, reside in a complex microenvironment, which influences biology and activity of the cells. The protective role of bone marrow stromal cells is already commonly recognized. Remodeling of stroma cell functions by leukemia cells is also well documented. In this respect, different routes of interactions were defined, such as direct cell-cell interactions or indirect cross talk, by release of soluble factors or vesicular particles containing proteins, RNAs and other molecules.… Show more

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“…For imaging EVs with fluorescent labeling, one can pick variety of fluorescent dyes (Piwocka et al., 2018); however, as dyes have different biochemical properties, their use may in some cases be limited. CFSE (CFDA‐SE) becomes fluorescent after cleavage by esterases, so it will not stain EVs that do not contain these enzymes (though rare).…”
Section: Commentarymentioning
confidence: 99%
“…For imaging EVs with fluorescent labeling, one can pick variety of fluorescent dyes (Piwocka et al., 2018); however, as dyes have different biochemical properties, their use may in some cases be limited. CFSE (CFDA‐SE) becomes fluorescent after cleavage by esterases, so it will not stain EVs that do not contain these enzymes (though rare).…”
Section: Commentarymentioning
confidence: 99%