Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke

Zhu, Yuanhan; Sun, Yulin; Hu, Jichao; Pan, Zhuoer

doi:10.3389/fphar.2022.866360

Cited by 16 publications

(9 citation statements)

References 131 publications

(129 reference statements)

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“…All these findings showed that the improvement of glymphatic activity after IS could effectively reduce brain edema and promote recovery from motor dysfunction, which explained the connection between glymphatic activity and motor dysfunction. One of the principles of the treatment of IS is to remove harmful metabolites (Zhu et al, 2022). Recent studies have found that voluntary wheel operation accelerated the clearance of glymphatic function and protected mouse synaptic function (He et al, 2017).…”

Section: Relationship Between Damaged Glymphatic System and Motor Dys...mentioning

confidence: 99%

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Qin

Li²,

Qiao

et al. 2023

Front. Neurosci.

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PurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.MethodsTwenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively.ResultsSix IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group (t = −3.02, p = 0.004). In the IS group, a positive correlation between the left DTI-ALPS index and the simple Fugl-Meyer motor function score (ρ = 0.52, p = 0.019) and a significant negative correlation between the left DTI-ALPS index and the FA (R = −0.55, p = 0.023) and MD (R = −0.48, p = 0.032) values of the right CST were found.ConclusionsGlymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS.

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Section: Relationship Between Damaged Glymphatic System and Motor Dys...mentioning

confidence: 99%

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Qin

Li²,

Qiao

et al. 2023

Front. Neurosci.

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“…Apoptosis is programmed cell death; its features are cellular swelling, film rupture, and random degradation of DNA ( Zhu et al, 2022 ). There are three kinds of apoptosis pathways, which are the endoplasmic reticulum, receptor, and chondriosome pathways ( Park et al, 2021 ).…”

Section: Mechanisms Of Exercise For Pain Management In Diseasementioning

confidence: 99%

“…When the body is stimulated, oxidative damage to the mitochondria leads to the increased release of pro-apoptotic mediators, which disrupts the oxidation antioxidant balance and leads to the damage of the oxidation organization ( Lushchak et al, 2021 ). Exercise can promote the production of reactive oxygen species in cells, further eliminating them to maintain body homeostasis ( Zhu et al, 2022 ). Meanwhile, long or short-term pretreatment can improve the levels of antioxidant enzymes in the hippocampus and cortex and inhibit some oxidative stress.…”

Section: Mechanisms Of Exercise For Pain Management In Diseasementioning

confidence: 99%

The mechanism of exercise for pain management in Parkinson’s disease

Yang

Wang

2022

Front. Mol. Neurosci.

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The research and clinical applications of exercise therapy to the treatment of Parkinson’s disease (PD) are increasing. Pain is among the important symptoms affecting the daily motor function and quality of life of PD patients. This paper reviewed the progress of research on different exercise therapies for the management of pain caused by PD and described the role and mechanism of exercise therapy for pain relief. Aerobic exercise, strength exercise, and mind-body exercise play an effective role in pain management in PD patients. The pain suffered by PD patients is divided into central neuropathic, peripheral neuropathic, and nociceptive pain. Different types of pain may coexist with different mechanistic backgrounds and treatments. The analgesic mechanisms of exercise intervention in PD-induced pain include altered cortical excitability and synaptic plasticity, the attenuation of neuronal apoptosis, and dopaminergic and non-dopaminergic analgesic pathways, as well as the inhibition of oxidative stress. Current studies related to exercise interventions for PD-induced pain suffer from small sample sizes and inadequate research of analgesic mechanisms. The neurophysiological effects of exercise, such as neuroplasticity, attenuation of neuronal apoptosis, and dopaminergic analgesic pathway provide a sound biological mechanism for using exercise in pain management. However, large, well-designed randomized controlled trials with improved methods and reporting are needed to evaluate the long-term efficacy and cost-effectiveness of exercise therapy for PD pain.

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“…Xenobiotic-induced preconditioning in stroke is known as "pharmacological preconditioning," which is referred to as increased tissue tolerance in long-term ischemic injury. 60 It may limit cell death and infarct size and improve organ function. It is an effective neuroprotective method against stroke that can be attained by various agents.…”

Section: Xenobiotic Preconditioningmentioning

confidence: 99%

Aspects of xenobiotics and their receptors in stroke

et al. 2022

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Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic strategies for ischemic stroke primarily aim to restore cerebral blood flow by removing clots using intravenous thrombolysis and mechanical thrombectomy. However, hemorrhagic stroke requires different therapeutic interventions, where intravenous thrombolysis worsens the persistent condition. Nevertheless, the present treatment strategies do not provide effective neuroprotection as they have limitations such as narrow time window, specialized clinics and personnel, and higher expense. Therefore, studies on novel therapeutic strategies that can render neuroprotection over an extended time with minimum adverse effects are solicited. Xenobiotics are agents that are foreign to the biological system but can regulate their metabolism by binding to different xenobiotic receptors (XRs) to produce toxic substances. Modulation of XRs in different preclinical studies have shown benefits in the stroke outcome. Therefore, targeting XRs may be a future therapeutic strategy for stroke intervention. The present review briefly discusses various implications of xenobiotics and their receptors to evolve as a potential therapeutic target for prospective use as an adjunctive therapy for stroke.

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Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke

Cited by 16 publications

References 131 publications

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

The mechanism of exercise for pain management in Parkinson’s disease

Aspects of xenobiotics and their receptors in stroke

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