Insight into the role of hydrochloric acid in the thermodynamics and nucleation kinetics behavior of Arbidol hydrochloride monohydrate from metastable zone widths

Abstract

In order to investigate the nucleation behavior of arbidol hydrochloride monohydrate (AHM) in the aqueous THF (Tetrahydrofuran) solutions, metastable zone width (MSZW) was experimentally determined via the polythermal method, and...

Uncovering the Solvent–Solute Interaction Mechanism in Nucleation of Erythritol Based on Metastable Zone Widths: Experimental Kinetics and Molecular Dynamics Simulations

“…To uncover the effect of cooling rate on the nucleation kinetics of ERT, the modified Sangwal’s theoretical model was taken to analyze the variation of maximum undercooling Δ T max with the cooling rate. As seen in Figure , when the saturation temperature was higher, the slope was larger, indicating that the cooling rate exerted larger impact on MSZWs, which was consistent with the previous research results . At the same saturation temperature, ( T 0 /Δ T ) 2 /( T 0 – Δ T ) vs ln ( R /[ T 0 ( T 0 – Δ T )] had a linear relationship, and the corresponding intercept and slope could be obtained.…”

“…The solubility of ERT in DMF and n -propanol was determined by the laser-monitoring method, described in our previous work in detail. , The experimental instrument involved a 100 mL crystallizer with stirring, which was connected to a thermostatic bath to ensure the experimental temperature was maintained (±0.01 K). First, a certain mass of solvent was weighed with an analytical balance (±0.0001 g) and added into the crystallizer that had reached the experimental temperature.…”

“…Far inferior to crystal growth, however, nucleation is still much less well-understood due to the stochastic nature of nucleation and the difficulty of detecting the nanometer size nuclei directly at the actual time, resulting in the coexistence of several nucleation mechanisms, such as Classical Nucleation Theory (CNT) and non-Classical Nucleation Theory (non-CNT, i.e. mainly the two-step nucleation (TSN) and prenucleation clusters (PNCs) theory). , …”

Prediction of metastable zone widths of ammonium sulphate: modification of the nucleation potential model in an electrolyte system

“…4,5,[29][30][31][32][33][34][35] The influences of the existence of different impurity ions, 30,31,33,34,36 pH value, 5,32,35,37 and stirring speed 4,5 on the crystal habit and particle size distribution of ammonium sulphate have been investigated, which will also influence the morphology and size distribution of the final crystalline product. 38 Trivalent ions Fe 3+ , Cr 3+ , and Al 3+ were reported to widen the MSZWs of ammonium sulphate, where the pH also played an important role in the effect of impurity ions. 34 The crystal size can be optimized with the content level of impurity in the solution.…”

Intensive Research on the Nucleation Induction Time in Cooling Crystallization of the Myo-inositol–Water System: Data Measurement and Establishment of Prediction Models

“…Since the measurement of the induction time is a time-consuming process, calculating the induction time through predictive models will provide great convenience for industrial production. Based on classical nucleation theory, the relationship between the induction time and saturation ratio can be quantitatively studied. − The linear stirring speed and temperature are the key factors affecting the induction time. To predict the induction time in industrial production, two factors must be considered in the model.…”