Insight into the role of DPP-4 in fibrotic wound healing

Zhang, Kai-Wen; Liu, Siyu; Jia, Yuan; Zou, Ming-Li; Teng, Ying-Ying; Chen, Zhonghua; Li, Yueyue; Guo, Dan‐Yang; Wu, Junjie; Yuan, Zheng‐Dong; Yuan, Feng‐Lai

doi:10.1016/j.biopha.2022.113143

Cited by 19 publications

(16 citation statements)

References 86 publications

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“…In the subcapsular zone we characterize important roles of specialized fibroblast cells, where DPP4 + capsular fibroblasts respond to systemic hormone levels and capsular fibroblasts contribute to DP development indirectly through maintenance of cortical epithelial cells, as well as directly through immunoregulatory growth factors. DPP4 + capsular fibroblasts have been described in mouse in the thymic capsule 83 and elsewhere as cells with progenitor and anti-fibrotic potential [84][85][86][87] . Here, we observe that DPP4 marks a subset of capsule fibroblasts which can respond to changes in systemic hormone levels.…”

Section: Discussionmentioning

confidence: 99%

Sex biased human thymic architecture guides T cell development through spatially defined niches

Stankiewicz

Rossi

Zandstra

et al. 2023

Preprint

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Within the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell development we employed the multidimensional imaging platform CO-detection by indEXing (CODEX), as well as CITE-seq and ATAC-seq. We generated age-matched 4-5-month-old postnatal thymus datasets for male and female donors, and identify significant sex differences in both T cell and thymus biology. We demonstrate a crucial role for JAG ligands in directing thymic-like dendritic cell development, reveal important functions of a novel population of ECM- fibroblasts, and characterize the medullary niches surrounding Hassall's corpuscles. Together, these data represent a unique age-matched spatial multiomic resource to investigate how sex-based differences in thymus regulation and T cell development arise, and provide an essential resource to understand the mechanisms underlying immune function and dysfunction in males and females.

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Section: Discussionmentioning

confidence: 99%

Sex biased human thymic architecture guides T cell development through spatially defined niches

Stankiewicz

Rossi

Zandstra

et al. 2023

Preprint

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“…Interestingly, increased DPP-IV levels are observed in obese patients and correlate with a higher risk for the development of metabolic complications [ 63 ]. Moreover, increased DPP-IV could also provide a link with the fibrotic states detected in aged NRK1 KO mice, as DPP-IV can trigger multiple processes leading to fibrotic extracellular matrix depositions [ 64 , 65 ]. Oppositely, the inhibition of DPP-IV has been shown to attenuate fibrosis in liver [ 65 , 66 ] and kidney [ [67] , [68] , [69] ].…”

Section: Discussionmentioning

confidence: 99%

Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure

Cercillieux

Ratajczak²,

Joffraud³

et al. 2022

Molecular Metabolism

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“…82,86 Although in Taiwan, DPP-4 inhibitors (DPP-4i) effect on the bone health in T2DM patients seemed to be supported by largescale population-based study as shown by Dr. Chang's group, 56 and additionally, DPP-4 has been extensively reviewed to provide the possible benefits on bone and subcutaneous tissue (extracelluar matrix), which are key factors of bone health. 89,90 Similar to many large-scale population-based studies, 31,56,63,[83][84][85][86][91][92][93][94][95][96][97][98] many biases, which cannot be totally excluded, may decrease the reliability and reproducibility of the data analysis. Additionally, DPP-4i may increase the risk of cholecystitis in randomized controlled trials, especially with longer treatment duration, 99 although the population-based cohort study did not support the current use of DPP-4i was associated with an increased risk of bile duct and gallbladder disease compared with current use of at least 2 oral ADA (adjusted HR, 0.99; 95% CI, 0.75-1.32).…”

Section: Antidiabetic Agents and Bonementioning

confidence: 99%

To do one and to get more: Part I. Diabetes and bone

Lee

Wang

Yang

et al. 2022

Journal of the Chinese Medical Association

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Type 2 diabetes mellitus (T2DM), is a chronic metabolic disease, characterized by the presence of hyperglycemia and insulin resistance. The key treatment strategies for T2DM include modification of lifestyle, medications, and continuous glucose monitoring. DM patients often have DM-associated morbidities and comorbidities; however, disorders of musculoskeletal system are often neglected, compared to other major systems in DM patients. Based on sharing similar pathophysiology of DM and osteoporosis, it is supposed that the use of antidiabetic agents (ADAs) may not only provide the lowering glucose level effect and the maintenance of the sugar homeostasis to directly delay the tissue damage secondary to hyperglycemia but also offer the benefits, such as the prevention of developing osteoporosis and fractures. Based on the current review, evidence shows the positive correlation between DM and osteoporosis or fracture, but the effectiveness of using ADA in the prevention of osteoporosis and subsequent reduction of fracture seems to be inconclusive. Although the benefits of ADA on bone health are uncertain, the potential value of "To do one and to get more" therapeutic strategy should be always persuaded. At least, one of the key treatment strategies as an establishment of healthy lifestyle may work, because it improves the status of insulin resistance and subsequently helps DM control, prevents the DM-related micro-and macrovascular injury, and possibly strengthens the general performance of musculoskeletal system. With stronger musculoskeletal system support, the risk of "fall" may be decreased, because it is associated with fracture. Although the ADA available in the market does not satisfy the policy of "To do one and to get more" yet, we are looking forward to seeing the continuously advanced technology of drug development on diabetic control, and hope to see their extra-sugar-lowering effects.

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Insight into the role of DPP-4 in fibrotic wound healing

Cited by 19 publications

References 86 publications

Sex biased human thymic architecture guides T cell development through spatially defined niches

Sex biased human thymic architecture guides T cell development through spatially defined niches

Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure

To do one and to get more: Part I. Diabetes and bone

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