Insight on Mercapto-Coumarins: Synthesis and Reactivity

Abstract

Mercapto (or sulfanyl)-coumarins are heterocycles of great interest in the development of valuable active structures in material and biological domains. They represent a highly exploitable class of compounds that open many possibilities for further chemical transformations. The present review aims to draw focus toward the synthetic applicability of various forms of mercapto-coumarins and their representations in pharmaceuticals and industries. This work covers the literature issued from 1970 to 2021.

The α-alkylation of carbonyl sulfoxonium ylides: studies and applications in the synthesis of new sulfur heterocycles

“…Moreover, they exhibit cytotoxic and anti-HBV activities. 46,47 A new coumarin derivative (5a) was synthesized in 78% yield by reacting 7-mercapto-4-methylcoumarin under the conditions of acetonitrile at 60 °C for 48 hours.…”

Methylthio‐substituted coumarin‐based fluorescent probe for highly specific and fast detection of hypochlorite and bioimaging application

“…Such a transformation of functional groups might be used to sense oxidising species. [31][32][33][34] Though a number of alkylthio-substituted coumarin derivatives have been reported for their significant roles in medicinal chemistry and biological chemistry, [59][60][61] their utility as fluorescent probes for ClO À detection has not been developed yet. We designed the probe MOMTC as shown in Scheme 1 based on the following considerations.…”

l-Proline-Catalyzed Three-Component Reaction of 4-Chloro-3-formylcoumarin, Sodium Sulfide, and α-Halo Ketones: A Direct Approach to Thieno[3,2-c]coumarins

“…Fusions of thiophene to the pyrone ring of coumarin result in three structural isomers based on the position of the sulfur atom, one of which is thieno[3,2- c ]coumarin. 39…”