Insight on recent development in metallic biomaterials: Strategies involving synthesis, types and surface modification for advanced therapeutic and biomedical applications

Thanigaivel, S.; Priya, A.K.; Balakrishnan, Deepanraj; Dutta, Kingshuk; Rajendran, Saravanan; Soto-Moscoso, Matias

doi:10.1016/j.bej.2022.108522

Cited by 31 publications

(11 citation statements)

References 42 publications

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“…The regulation of reactivity between implant materials and the surrounding biological environment can hasten the recovery process [ 16 ]. Dolcimascolo et al [ 17 ] assert that three generations of biomaterials have been utilized in the past 60 years: bio-inert materials (first generation), bioactive or biodegradable materials (second generation), and current materials (third generation).…”

Section: The Generation Of Biomaterialsmentioning

confidence: 99%

“…Cobalt-based alloys are known to possess superior biocompatibility and corrosion resistance in comparison to stainless steel alloys, despite their higher production costs. Certain cobalt–chromium–molybdenum alloys are utilized specifically for hip prosthesis implants [ 16 , 121 ]. Due to its excellent abrasion resistance, this alloy type is only used in metal-to-metal devices [ 122 ].…”

Section: Metalmentioning

confidence: 99%

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The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future

et al. 2023

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As the area and range of surgical treatments in the orthopedic field have expanded, the development of biomaterials used for these treatments has also advanced. Biomaterials have osteobiologic properties, including osteogenicity, osteoconduction, and osteoinduction. Natural polymers, synthetic polymers, ceramics, and allograft-based substitutes can all be classified as biomaterials. Metallic implants are first-generation biomaterials that continue to be used and are constantly evolving. Metallic implants can be made from pure metals, such as cobalt, nickel, iron, or titanium, or from alloys, such as stainless steel, cobalt-based alloys, or titanium-based alloys. This review describes the fundamental characteristics of metals and biomaterials used in the orthopedic field and new developments in nanotechnology and 3D-printing technology. This overview discusses the biomaterials that clinicians commonly use. A complementary relationship between doctors and biomaterial scientists is likely to be necessary in the future.

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Section: The Generation Of Biomaterialsmentioning

confidence: 99%

Section: Metalmentioning

confidence: 99%

The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future

et al. 2023

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“…This is permitted if the process does not compromise the mechanical strength or produce hazardous residues (Todros et al, 2021). In contrast to common belief, current research indicates that the acceleration of the restoration process can be achieved through the implementation of a carefully controlled reactivity between the implanted substances and the surrounding biological environment (Thanigaivel et al, 2022). The progress in biomaterials has facilitated the development of substances possessing unique characteristics that contribute to the compatibility of grafts with the morphological and mechanical properties of the recipient's structure.…”

Section: Biological Needsmentioning

confidence: 99%

Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective

Chen,

Zhou,

Jiang

et al. 2023

Front. Bioeng. Biotechnol.

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The objective of bioimplant engineering is to develop biologically compatible materials for restoring, preserving, or altering damaged tissues and/or organ functions. The variety of substances used for orthopedic implant applications has been substantially influenced by modern material technology. Therefore, nanomaterials can mimic the surface properties of normal tissues, including surface chemistry, topography, energy, and wettability. Moreover, the new characteristics of nanomaterials promote their application in sustaining the progression of many tissues. The current review establishes a basis for nanotechnology-driven biomaterials by demonstrating the fundamental design problems that influence the success or failure of an orthopedic graft, cell adhesion, proliferation, antimicrobial/antibacterial activity, and differentiation. In this context, extensive research has been conducted on the nano-functionalization of biomaterial surfaces to enhance cell adhesion, differentiation, propagation, and implant population with potent antimicrobial activity. The possible nanomaterials applications (in terms of a functional nanocoating or a nanostructured surface) may resolve a variety of issues (such as bacterial adhesion and corrosion) associated with conventional metallic or non-metallic grafts, primarily for optimizing implant procedures. Future developments in orthopedic biomaterials, such as smart biomaterials, porous structures, and 3D implants, show promise for achieving the necessary characteristics and shape of a stimuli-responsive implant. Ultimately, the major barriers to the commercialization of nanotechnology-derived biomaterials are addressed to help overcome the limitations of current orthopedic biomaterials in terms of critical fundamental factors including cost of therapy, quality, pain relief, and implant life. Despite the recent success of nanotechnology, there are significant hurdles that must be overcome before nanomedicine may be applied to orthopedics. The objective of this review was to provide a thorough examination of recent advancements, their commercialization prospects, as well as the challenges and potential perspectives associated with them. This review aims to assist healthcare providers and researchers in extracting relevant data to develop translational research within the field. In addition, it will assist the readers in comprehending the scope and gaps of nanomedicine’s applicability in the orthopedics field.

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“…Despite their difficult fabrication, Co-based alloys are more resilient to corrosion and wear and display better biocompatibility [65]. Alloyed with Cr and Mo, some Co-based alloys like Co-Cr-Mo and Co-Ni-Cr-Mo are specially used for implants in the hip, knee and shoulder prosthesis [66]. Compared with other metallic implants, Co-based alloys display a better elastic modulus, stiffness and high density (8.3 g/cm 3 ) [67].…”

Section: Co-cr Alloysmentioning

confidence: 99%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide the needed physical and mechanical properties for load-bearing applications. Although widely used as biomedical materials for the replacement of hard tissue, metallic implants still confront challenges, among which the foremost is their low biocompatibility. Some of them also suffer from excessive wear, low corrosion resistance, infections and shielding stress. To address these issues, various coatings have been applied to enhance their in vitro and in vivo performance. When merged with the beneficial properties of various bio-ceramic or polymer coatings remarkable bioactive, osteogenic, antibacterial, or biodegradable composite implants can be created. In this review, bioactive and high-performance coatings for metallic bone implants are systematically reviewed and their biocompatibility is discussed. Updates in coating materials and formulations for metallic implants, as well as their production routes, have been provided. The ways of improving the bioactive coating performance by incorporating bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs that are locally released in a controlled manner have also been addressed.

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Insight on recent development in metallic biomaterials: Strategies involving synthesis, types and surface modification for advanced therapeutic and biomedical applications

Cited by 31 publications

References 42 publications

The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future

The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future

Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

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