Insight on thermal behaviour of new complexes of Ni(II), Cu(II) and Zn(II) with a bismacrocyclic ligand developed as biologically active species

Badea, Mihaela; Bucur, Cristina; Chifiriuc, Mariana Carmen; Bleoţu, Coralia; Grecu, Maria Nicoleta; Lazăr, Veronica; Marinescu, Dana; Olar, Rodica

doi:10.1007/s10973-016-5502-y

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“…A similar multi-component reaction involving metal ion, amines and formaldehyde has been used for another series of decaaza bismacrocycle-based complexes [M 2 (bmc2)X 4 ·nH 2 O ( 54/55 ) (M: Ni, Cu, Zn, bmc2: 1,3-bis( N , N -1,3,6,9,12-pentaazacyclotridecane)-benzene, X: Cl [ 129 ], CH 3 COO [ 130 ]) development as anti-biofilm species. The assays on a plethora of microorganisms ( B. subtilis , E. faecalis , S. aureus , S. epidermidis , E. cloacae , E. coli , K. pneumoniae , Proteus mirabilis , P. aeruginosa , C. albicans and C. krusei ) demonstrated good anti-biofilm activity of Cu(II) complexes on fungal strains, the acetate species being more active compared with the chloride one.…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%