Insight, symptoms and neurocognition in bipolar I patients

Varga, Monica; Magnússon, Andrés; Flekkøy, Kjell; Rønneberg, Unni; Opjordsmoen, Stein

doi:10.1016/j.jad.2005.09.002

Cited by 79 publications

(63 citation statements)

References 35 publications

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“…Além disso, um prejuízo na fluência verbal foi significativamente associado com comprometimento do insight 17 . Esses resultados reforçam a noção de que o insight é uma capacidade neurocognitiva, com os achados indicando especificamente disfunção pré-frontal e frontoparietal em pacientes bipolares com baixo insight 17,64 . Os lobos frontais estão envolvidos em habilidades metacognitivas e de autoavaliação, tendo sido implicados na deficiên-cia de insight em diferentes grupos clínicos, como pacientes com doença de Alzheimer 19 .…”

Section: Discussionunclassified

“…Os nove estudos 17,36,38,45,47,50,55,64,67 sobre a relação entre o insight no TB e avaliações neuropsicológicas são apresentados na tabela 5.…”

Section: Avaliação Neuropsicológicaunclassified

“…Foram encontradas associações entre um menor insight e um maior comprometimento de memória 17,45,47,50 e de aprendizagem emocional 50 , de inteligência geral e de função psicomotora 36,64 , de compreensão e de habilidades perceptivo-motoras 17,47 , de atenção 17,36,64 , de fluência verbal 17,67 e de função executiva 17,45,47 , e ainda de maior velocidade de processamento 50 . 68 comparou eutímicos e deprimidos e relatou que insight dos eutímicos era igual ao dos deprimidos.…”

Section: Avaliação Neuropsicológicaunclassified

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O insight no transtorno bipolar: uma revisão sistemática

Silva

Mograbi²,

Landeira-Fernández

et al. 2014

J. bras. psiquiatr.

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rESUMo objetivos: Realizar uma revisão sistemática para compreender que fatores estão relacionados a uma maior ou menor consciência de morbidade no transtorno bipolar (TB), como o insight varia em função do estado afetivo e estabelecer uma comparação com outros transtornos mentais. Métodos: Realizou-se uma revisão sistemática da literatura científica sobre o insight em pacientes com TB. Foram buscados estudos clínicos originais sobre o tema nas bases de dados Medline, ISI e SciELO. Os termos de busca empregados foram: "insight" OR "awareness" AND "bipolar" OR "mania" OR "manic". resultados: Foram selecionados 55 artigos. O insight no TB parece ser mais prejudicado do que na depressão unipolar, porém menos do que na esquizofrenia. Com relação ao TB, um menor nível de insight está relacionado à presença de sintomas psicóticos e de alterações cognitivas. Além disso, um comprometimento do insight está associado a uma menor adesão ao tratamento. Por outro lado, uma maior preservação do insight pode estar associada a maior ideação suicida. Finalmente, a fase maníaca cursa com um nível inferior de insight quando comparada à fase depressiva ou de eutimia. Conclusão: No TB, o insight está significativamente prejudicado, especialmente na mania. Diversos fatores clínicos parecem influenciar o nível de insight. aBStraCt objectives: To conduct a systematic review to understand which factors are related to insight in bipolar disorder (BD), how insight varies depending on affective state and to establish a comparison between BD and other mental disorders. Methods: We performed a systematic review of the scientific literature on insight in BD patients. Clinical studies on the topic were searched in the Medline, SciELO and ISI databases. The search terms used were: "insight" OR "Awareness" AND "bipolar" OR "mania". results: Fifty-five articles were selected. Insight in BD is more compromised than in unipolar depression, but less than in schizophrenia. A lower level of insight is related to the presence of psychotic symptoms and cognitive disorders. Moreover, insight impairment is associated with lower adherence to treatment. On the other hand, a greater preservation of insight may be associated with increased suicidal ideation. Finally, the manic phase is characterized by a lower level of insight than the depressive phase or euthymia. Conclusion: Insight is greatly impaired in BD, especially during mania. Several clinical factors seem to influence the level of insight.

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Section: Discussionunclassified

“…Os nove estudos 17,36,38,45,47,50,55,64,67 sobre a relação entre o insight no TB e avaliações neuropsicológicas são apresentados na tabela 5.…”

Section: Avaliação Neuropsicológicaunclassified

See 1 more Smart Citation

O insight no transtorno bipolar: uma revisão sistemática

Silva

Mograbi²,

Landeira-Fernández

et al. 2014

J. bras. psiquiatr.

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“…Substance use disorders were associated with the lack of insight into illness, as it also happens in various psychotic and mood disorders, as well as in obsessive-compulsive disorder (Husted, 1999;Pallanti et al, 1999;Pini et al, 2001;Dell'Osso et al, 2002;Marazziti et al, 2002;Varga et al, 2006;Verdejo-García and Pérez-García, 2008;Maremmani et al, 2012). Zeng et al (2013) did not find any significant correlation between selfreported impulsivity scores and inhibition deficits, showing that heroin-addicted individuals do not have insight of their actual mental or physical condition.…”

Section: Abnormal Resting-state Topological Properties In Heroin-depementioning

confidence: 99%

Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractDrug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific regions in the prefrontal, parietal, occipital, and temporal lobes, as well as, some subcortical regions.The brain regions involvedare linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control andseem to form circuitsthat interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively reviewand discuss all the existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapya multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games Keywords:Heroin addiction, resting-state, functional and structural connectivity, small-world properties, behavioral traits of heroin-dependent individuals. Radial Diffusivity (RD) 5 Drug addiction or substance dependence (Koob and Le Moal, 2005)is defined as a multifaceted neuropsychiatric disorder resulting from complex interactions between neurobiological, environmental, genetic and pharmacological variables (Sutherland et al., 2012).It affects both cognitive as well as emotional processes . Furthermore, the compulsive seeking and taking of the drug despite the negative consequences, (including downward social mobility (Denier et al., 2013b)), constitutes its behavioral phenotype (Volkow ...

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“…Poor treatment adherence and poor outcome were associated with poor insight in bipolar patients. 8 In recent years it has become more and more important to assess the well-being of patients in different domains such as social, physical and occupational functioning. Improving Quality of life is one of the treatment goals in patients with bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%