Insights for the Inhibition of Cancer Progression: Revisiting Ca2+ and Camp Signalling Pathways

Abstract

This editorial article gives insights for the inhibition of cancer progression. The pharmacological modulation of Ca 2+ /cAMP signalling interaction is also cited.

Extracellular Cyclic AMP/Adenosine Signaling Pathway: A Potential Pharmacological Target for Therapeutic Intervention in Chronic Lymphocytic Leukemia

“…In addition, considering the existence of a cAMP efflux system mediated by multiresistant protein transporters: the blockade of adenosine receptors reduces the negative inotropic effect promoted by extracellular adenosine due to cAMP efflux system, altering important intracellular signaling pathways [20,21]. Thus, we have proposed that the pharmacological modulation of the intra and extracellular signaling mediated by cAMP and adenosine could be a new antitumoral strategy in CLL therapy [22][23][24][25][26].…”

The “Calcium Paradox” Discovery: Impact i n Translational Research

“…In addition, it has been shown that the dysregulation of intracellular signaling pathways mediated by Ca 2+ and cAMP participates in the cancer initiation, tumor formation, tumor progression, metastasis, invasion and angiogenesis. Thereby, proteins involved in these pathways, such as Ca 2+ channels and cAMP-dependent protein kinase (PKA), represent potential drugs targets for cancer therapy [20]. With this concept in mind, some studies showed that drugs able to interfere with the intracellular Ca 2+ signaling such as selective VACCs blockers, as amlodipine, inhibit proliferative response in different cancer cells.…”

“…With this concept in mind, some studies showed that drugs able to interfere with the intracellular Ca 2+ signaling such as selective VACCs blockers, as amlodipine, inhibit proliferative response in different cancer cells. In addition, drugs able to increase the intracellular cAMP levels (cAMP-enhancer compounds), such as PDE 4 inhibitors, have been proposed as potential adjuvant, chemotherapeutic or chemopreventive agents in some cancer types, including hepatocellular carcinoma [20]. Then, the pharmacological modulation of the intracellular signaling mediated by Ca 2+ and cAMP in the cancer cells may represent a new therapeutic strategy for cancer progression.…”

Novel Concepts for Clinical Pharmacology from "Calcium Paradox" due to Neuronal Interaction between Signalling Pathways Mediated by Ca2+ and cAMP from 1975 to 2017

“…In addition, it has been shown that the dysregulation of intracellular signaling pathways mediated by Ca 2+ and cAMP participates in the cancer initiation, tumor formation, tumor progression, metastasis, invasion and angiogenesis. Thereby, proteins involved in these pathways, such as Ca 2+ channels and cAMP-dependent Protein Kinase (PKA), represent potential drugs targets for cancer therapy [24]. With this concept in mind, some studies showed that drugs able to interfere with the intracellular Ca 2+ signaling such as selective CCBs, as amlodipine, inhibit proliferative response in different cancer cells [24][25][26][27].…”

“…Thereby, proteins involved in these pathways, such as Ca 2+ channels and cAMP-dependent Protein Kinase (PKA), represent potential drugs targets for cancer therapy [24]. With this concept in mind, some studies showed that drugs able to interfere with the intracellular Ca 2+ signaling such as selective CCBs, as amlodipine, inhibit proliferative response in different cancer cells [24][25][26][27]. In addition, drugs able to increase the intracellular cAMP levels (cAMP-enhancer compounds), such as Phosphodiesterase (PDE) 4 inhibitors, have been proposed as potential adjuvant, chemotherapeutic or chemopreventive agents in some cancer types, including hepatocellular carcinoma [28].…”