Insights from a laboratory and naturalistic investigation on stress, rumination and frontal brain functioning in MDD: An fNIRS study

Rosenbaum, David; Int-Veen, Isabell; Laicher, Hendrik; Torka, Florian; Kroczek, Agnes; Rubel, Julian; Lawyer, Glenn; Bürger, Zoé; Bihlmaier, Isabel; Storchak, Helena; Velten-Schurian, Kerstin; Dresler, Thomas; Täglich, Ramona; Schopp, Betti; Nürk, Hans-Christoph; Derntl, Birgit; Nieratschker, Vanessa; Fallgatter, Andreas J.; Ehlis, Ann‐Christine

doi:10.1016/j.ynstr.2021.100344

Cited by 19 publications

(33 citation statements)

References 55 publications

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“…Generally, increased activity in regions of the Cognitive Control Network (CCN), comprising the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) and posterior parietal cortex 47 , was observed in fNIRS and fMRI studies as a correlate of social stress induction 48 . Furthermore, in one of our previous studies 22,45 we found decreased activity in the bilateral inferior frontal Gyrus (IFG) as a mediator of post-stress rumination. As the IFG is relevant in inhibition and attention control tasks [48][49][50][51][52][53][54][55] , this nding let us conclude that inhibition of the IFG and therefore of these tasks might lead to rumination.…”

Section: Introductionmentioning

confidence: 81%

“…We adapted the TSST according to the fNIRSsetting by performing a 7-min resting-state previous to two non-stressful control tasks and another 7-min resting-state after the TSST. Through this adaptation, the TSST delivered an ecologically valid and fNIRSconform stress situation, that leads to post-event processing in rumination-vulnerable and/or anxious subjects 22,45 . Due to saliva sampling, participants rested for another 45 min, however fNIRS was not recorded during this part of the post-stress phase.…”

Section: Methodsmentioning

confidence: 99%

“…Further, at several time points, subjective stress was measured on a Visual Analogue Scale (VAS) ranging from 0-100% as well as samples of salivary cortisol were taken using Salivettes. As this investigation focused on behavioral data assessed by the aforementioned questionnaires and fNIRS data during the post-stress resting-state, in the following we will brie y describe these measures, however more detailed information regarding the stress induction and general procedure is to nd in 22,45 .…”

Section: Methodsmentioning

confidence: 99%

“…Investigating the neural correlates of social anxiety in a public speech task, Tuscan, et al 44 found elevated frontal cortical oxygenation using fNIRS, but no signi cant differences between high and low socially anxious individuals. Studies using the TSST in a sample of depressed patients revealed hypoactivity in the prefrontal cortex as well as increased state rumination and negative affect when compared to healthy controls 22,45,46 . Generally, increased activity in regions of the Cognitive Control Network (CCN), comprising the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) and posterior parietal cortex 47 , was observed in fNIRS and fMRI studies as a correlate of social stress induction 48 .…”

Section: Introductionmentioning

confidence: 96%

“…In two previous studies of our lab 22,45 , we investigated stress-induced rumination but did not test whether social anxiety has an in uence or explains unique variance. More speci cally, we investigated the e cacy of a socially stressful situation (the TSST) under laboratory conditions as well as its effects on postevent processing on a neuronal level to nd possible neuronal activation patterns for rumination in different sub-samples (high vs. low trait-ruminators, depressed vs. healthy subjects).…”

Section: Introductionmentioning

confidence: 99%

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Trait Rumination and Social Anxiety Separately Predict Stress Induced Rumination and Hemodynamic Responses

Laicher

Int-Veen

Torka

et al. 2021

Preprint

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We aimed to investigate the stress-reactive rumination response to social stress and its association with social anxiety and trait rumination. From previous investigations we know that people with a certain vulnerability to rumination show increased stress-reactive rumination. However, up to date the possible influence of social anxiety to this relationship is still unclear. Therefore, we reanalyzed the data of two of our previous studies assessing healthy low and high trait ruminators and depressed patients performing the Trier Social Stress Test (TSST). We measured cortical oxygenation using functional Near-Infrared Spectroscopy (fNIRS) as well as different behavioral outcome measures (subjective stress levels, negative affect, state rumination). On a behavioral level, we found an influence of both, social anxiety and trait rumination, on state rumination, even when correcting for the other factor, respectively, implying two potentially independent factors of influence. On a neural level, we observed reduced activation in socially anxious subjects in the right inferior frontal gyrus (IFG), as well as time-dependent changes in the left IFG and in the right dorsolateral prefrontal cortex. Results indicate a specific role of social anxiety, at least on a behavioral level, and therefore implicate a crucial factor to be considered in the treatment of depression.

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Section: Introductionmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Trait Rumination and Social Anxiety Separately Predict Stress Induced Rumination and Hemodynamic Responses

Laicher

Int-Veen

Torka

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

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The temporal dynamics of perceived stress and depression in college students: An ecological momentary assessment

Feng,

Xu,

et al. 2024

PsyCh Journal

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Previous studies have implied that stress is a risk factor for depression, but relatively little is known about how healthy individuals' stress dynamically affects depression as a mood in daily life. Therefore, an ecological momentary assessment study was conducted among 141 college students to test the temporal dynamic effect of daily perceived stress on depression and the underlying mediating and moderating role of rumination. Perceived stress, state rumination, and depression were measured using self‐compiled questionnaire three times a day over 12 days. Trait rumination was measured with the Nolen‐Hoeksema Ruminative Response Scale. Hierarchical linear models with HLM 7.0 were adopted to examine the mediation and moderation effects. In the mediation model, the greater the daily perceived stress at time t, the higher the state rumination at time t + 1, and state rumination at t + 1 positively predicted college students' depression at t + 2. In the moderation model, trait rumination significantly facilitated perceived stress‐induced depression. These results verified that daily perceived stress could affect college students' depression directly or indirectly through the critical mediating mechanism of state rumination, and this effect would be exacerbated with a higher level of trait rumination.

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Timing and cortical region matter: theta power differences between teenagers affected by Major Depression and healthy controls

Gradwohl,

Snipes,

Walitza

et al. 2024

J Neural Transm

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In adults affected by Major Depressive Disorder (MDD), most findings point to higher electroencephalographic (EEG) theta power during wake compared to healthy controls (HC) as a potential biomarker aiding the diagnostic process or subgrouping for stratified treatment. Besides these group differences, theta power is modulated by time of day, sleep/wake history, and age. Thus, we aimed at assessing if the time of recording alters theta power in teenagers affected by MDD or HC. Standardized wake EEG power was assessed with high-density EEG in 15 children and adolescents with MDD and in 15 age- and sex-matched HC in the evening and morning. Using a two-way ANOVA, group, time, and their interaction were tested. In patients, the current severity of depression was rated using the Children’s Depression Rating Scale. Broadband EEG power was lower in the morning after sleep, with a significant interaction (group x time) in central regions in the 4-6 Hz range. In MDD relative to HC, theta power was decreased over occipital areas in the evening and increased over frontal areas in the morning. A higher frontal theta power was correlated with more severe depressive mood in the morning but not in the evening. This was a cross-sectional study design, including patients on antidepressant medication. In conclusion, depending on time of recording, region-specific opposite differences of theta power were found between teenagers with MDD and HC. These findings stress the importance of the time of the recording when investigating theta power’s relationship to psychopathology.

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Insights from a laboratory and naturalistic investigation on stress, rumination and frontal brain functioning in MDD: An fNIRS study

Cited by 19 publications

References 55 publications

Trait Rumination and Social Anxiety Separately Predict Stress Induced Rumination and Hemodynamic Responses

Trait Rumination and Social Anxiety Separately Predict Stress Induced Rumination and Hemodynamic Responses

The temporal dynamics of perceived stress and depression in college students: An ecological momentary assessment

Timing and cortical region matter: theta power differences between teenagers affected by Major Depression and healthy controls

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