2018
DOI: 10.1101/254441
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Insights from deconvolution of cell subtype proportions enhance the interpretation of functional genomic data

Abstract: Cell subtype proportional differences between samples significantly contribute to variation of functional genomic properties such as gene expression or DNA methylation. Current analytical approaches typically deal with cell subtype proportion influences as a nuisance variable to be eliminated. Here we demonstrate how harvesting information about cell subtype proportions from functional genomics data provides insights into the cellular events in human phenotypes. We note a striking concordance between cell subt… Show more

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