Insights from experience in the treatment of tick-borne bacterial coinfections with tick-borne encephalitis

Kolyasnikova, Nadezhda M.; Sanchez-Pimentel, J. P.; Pestov, Nikolay B.

doi:10.1016/bs.armc.2022.08.004

Cited by 2 publications

(2 citation statements)

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“…Five members (tick‐borne encephalitis virus [TBEV], louping ill virus [LIV], Kyasanur Forest diseases virus [KFDV], Powassan virus [POWW] and Omsk hemorrhagic fever virus [OHFV]) comprise the human “tick‐borne encephalitis (TBE) serocomplex,” causing an estimated 12 000 annual cases of TBE in Europe and Asia 4 . TBEV is the largest causative agent of TBE, resulting in disease characterized by an initial nonspecific illness followed by central nervous system (CNS) inflammation and long‐term neurological symptoms in up to one half of the cases 5–7 . TBEV morbidity and mortality rates vary across its three main subtypes (European, Siberian, and far‐eastern), with the far‐eastern strain associated with the highest rates of neurological complications and a mortality rate of up to 40% 8 …”

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confidence: 99%

“…4 TBEV is the largest causative agent of TBE, resulting in disease characterized by an initial nonspecific illness followed by central nervous system (CNS) inflammation and long-term neurological symptoms in up to one half of the cases. [5][6][7] TBEV morbidity and mortality rates vary across its three main subtypes (European, Siberian, and far-eastern), with the far-eastern strain associated with the highest rates of neurological complications and a mortality rate of up to 40%. 8 Further study is needed to develop antivirals against TBEV (which are currently not available) and more optimized TBEV vaccines (which currently require three initial doses followed by booster doses at 3-5year intervals 9 ).…”

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Langat virus, a prototypic tick‐borne encephalitis virus, impacts IL‐6 signaling by downregulating gp130 expression

Brisse,

2024

Journal of Medical Virology

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confidence: 99%

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confidence: 99%

Langat virus, a prototypic tick‐borne encephalitis virus, impacts IL‐6 signaling by downregulating gp130 expression

Brisse,

2024

Journal of Medical Virology

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Neurological Complications Associated With the Powassan Virus and Treatment Interventions

Ndukwe,

Melville,

Osman

et al. 2024

Cureus

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Powassan virus (POWV), a flavivirus transmitted by Ixodes ticks, poses significant neurological risks, including encephalitis and meningitis. Despite its growing geographical spread and severe clinical manifestations, no specific antiviral treatments are currently available. This review synthesizes the existing literature on POWV, focusing on its epidemiology, clinical manifestations, neurological impact, and current treatment approaches. The review also explores the molecular biology of POWV, highlighting its genomic structure and the role of nonstructural proteins in its pathogenesis. POWV infection can range from asymptomatic to severe neurological disorders such as encephalitis and meningitis, with the latter presenting less severe outcomes. The pathophysiology of the virus involves immune evasion and robust neuroinflammation, complicating treatment strategies. Current management is supportive, with efforts ongoing to repurpose existing antivirals and develop new therapeutic interventions. Prognostic disparities between POWV-induced meningitis and encephalitis are notable, with meningitis generally having more favorable outcomes. The review also identifies critical gaps in POWV research, particularly in understanding the long-term neurological impacts and developing specific antiviral therapies. This article collates existing relevant literature on the POWV and culminates in two strategic actions: firstly, in the absence of an existing vaccine, it proposes repurposing antiviral drugs designed for related flaviviruses to target shared molecular pathways, such as nonstructural proteins in the POWV. Secondly, the article advocates for longitudinal studies to explore the long-term neurological effects on individuals who have survived POWV infections.

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Insights from experience in the treatment of tick-borne bacterial coinfections with tick-borne encephalitis

Cited by 2 publications

References 212 publications

Langat virus, a prototypic tick‐borne encephalitis virus, impacts IL‐6 signaling by downregulating gp130 expression

Langat virus, a prototypic tick‐borne encephalitis virus, impacts IL‐6 signaling by downregulating gp130 expression

Neurological Complications Associated With the Powassan Virus and Treatment Interventions

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