Insights from homozygous signatures of cervus nippon revealed genetic architecture for components of fitness

Goli, Rangasai Chandra; Mahar, Karan; Manohar, Peela Sai; Chishi, Kiyevi G; Prabhu, Immanual Gilwax; Choudhary, Sonu; Rathi, Pallavi; Chinnareddyvari, Chandana Sree; Haritha, Pala; Metta, Muralidhar; Shetkar, Mahantesh; Kumar, Amit; N D, Chethan Patil; Vidyasagar,; Sukhija, Nidhi; Kanaka, K. K.

doi:10.1007/s00335-024-10064-1

Mamm Genome

2024

DOI: 10.1007/s00335-024-10064-1

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Insights from homozygous signatures of cervus nippon revealed genetic architecture for components of fitness

Rangasai Chandra Goli,

Karan Mahar,

Peela Sai Manohar

et al.

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2024

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Runs of Homozygosity Decipher Genetic Diversity in Cattle Breed Dwelling in the Colder Regions of the World

Mahar,

Goli,

Chishi

et al. 2024

Cytogenet Genome Res

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Background Our study focuses on Yakutian cattle, a Siberian native breed, examining its inbreeding and diversity through genome-wide analysis of Runs of Homozygosity (ROH). Yakutian cattle are adapted to Siberia's harsh sub-arctic conditions, enduring temperatures below −70°C. However, the population genetics studies on this breed are scanty, to document the genetic uniqueness in this cattle. Results We analyzed 40 Yakutian cattle with strict quality control for ROH detection yielding 683 homozygous segments, averaging to 17 per individual with an average length of 9 Mb. ROH regions were found to be involved in important pathways pertaining to cold adaptation. Autozygosity ranged from 1% to 12% of the genome, with a relatively low average inbreeding coefficient (FROH) of 0.057309, as compared to other breeds. Also, the different diversity indicators namely, principal component analysis, heterozygosity and effective population size analysis revealed prevalence of genetic diversity within the breed. Conclusion Our findings on ROH are first of its kind in Yakutian cattle that support their adaptability to colder environments, as evidenced by low inbreeding and high genetic diversity.

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Runs of Homozygosity Decipher Genetic Diversity in Cattle Breed Dwelling in the Colder Regions of the World

Mahar,

Goli,

Chishi

et al. 2024

Cytogenet Genome Res

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show abstract

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Insights from homozygous signatures of cervus nippon revealed genetic architecture for components of fitness

Cited by 1 publication

References 89 publications

Runs of Homozygosity Decipher Genetic Diversity in Cattle Breed Dwelling in the Colder Regions of the World

Runs of Homozygosity Decipher Genetic Diversity in Cattle Breed Dwelling in the Colder Regions of the World

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