Insights into ablation of persistent atrial fibrillation: Lessons from 6‐year clinical outcomes

Brooks, Stephanie; Metzner, Andreas; Wohlmuth, Peter; Lin, Tina; Wißner, Erik; Tilz, Roland Richard; Rillig, Andreas; Mathew, Shibu; Saguner, Ardan M.; Heeger, Christian; Sohns, Christian; Kück, Karl‐Heinz; Ouyang, Feifan

doi:10.1111/jce.13401

Cited by 27 publications

(10 citation statements)

References 22 publications

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“…The multiple-procedure success rate of pulmonary vein isolation (PVI) in patients with PAF after a 5-year follow-up period has been reported to be approximately 80%, falling to about 60% after 10 years [10,11]. For patients with persistent AF, stable sinus rhythm (SR) after successful PVI was reported in 25% after a single procedure and in 68% after multiple procedures, during a median follow-up of approximately 7 years [12].…”

Section: Success Of Af Ablationmentioning

confidence: 99%

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives

Rottner

Bellmann²,

Lin

et al. 2020

Cardiol Ther

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Purpose of Review: Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with high rates of morbidity and mortality. Maintenance of stable sinus rhythm (SR) is the intended treatment target in symptomatic patients, and catheter ablation aimed at isolating the pulmonary veins provides the most effective treatment option, supported by encouraging clinical outcome data. A variety of energy sources and devices have been developed and evaluated. In this review, we summarize the current state of the art of catheter ablation of AF and describe future perspectives. Recent Findings: Catheter ablation is a wellestablished treatment option for patients with Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.11357912.

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Section: Success Of Af Ablationmentioning

confidence: 99%

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives

Rottner

Bellmann²,

Lin

et al. 2020

Cardiol Ther

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“…Due to its sustained nature, most patients progress from paroxysmal AF to persistent and longstanding persistent AF [2]. Importantly, therapy of (longstanding) persistent AF has high failure rates, with 20–60% of patients showing recurrence of AF within three months after ablation or electrical cardioversion [4,5,6,7]. Therapy failure in AF is related to the presence of structural remodeling of the myocardium, which, in turn, impairs electrical activation of the atria (“electropathology”) [8].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

Wiersma

Marion

Wüst

et al. 2019

Cells

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Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria, rendering them increasingly permissive to the arrhythmia. Previously, we reported on endoplasmic reticulum stress and NAD+ depletion in AF, suggesting a role for mitochondrial dysfunction in AF progression. Here, we examined mitochondrial function in experimental model systems for AF (tachypaced HL-1 atrial cardiomyocytes and Drosophila melanogaster) and validated findings in clinical AF. Tachypacing of HL-1 cardiomyocytes progressively induces mitochondrial dysfunction, evidenced by impairment of mitochondrial Ca2+-handling, upregulation of mitochondrial stress chaperones and a decrease in the mitochondrial membrane potential, respiration and ATP production. Atrial biopsies from AF patients display mitochondrial dysfunction, evidenced by aberrant ATP levels, upregulation of a mitochondrial stress chaperone and fragmentation of the mitochondrial network. The pathophysiological role of mitochondrial dysfunction is substantiated by the attenuation of AF remodeling by preventing an increased mitochondrial Ca2+-influx through partial blocking or downregulation of the mitochondrial calcium uniporter, and by SS31, a compound that improves bioenergetics in mitochondria. Together, these results show that conservation of the mitochondrial function protects against tachypacing-induced cardiomyocyte remodeling and identify this organelle as a potential novel therapeutic target.

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“…Therapy of persistent valvular AF has high failure rates, with 20%‐60% of patients showing recurrence of AF within three months after ablation 17 . Herein, at a mean follow‐up of 3 months, we found high recurrence rate of AF (53.…”

Section: Discussionmentioning

confidence: 72%

Preoperative monocyte‐to‐HDL‐cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation

Adili

Wang

Zhu

et al. 2020

Clinical Laboratory Analysis

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Insights into ablation of persistent atrial fibrillation: Lessons from 6‐year clinical outcomes

Cited by 27 publications

References 22 publications

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives

Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

Preoperative monocyte‐to‐HDL‐cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation

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