Insights into Behçet’s disease

Shahneh, Fatemeh Zare; Babalo, Zohreh; Baradaran, Behzad; Sepehr, Koushan Sineh

doi:10.5114/pdia.2012.32395

Cited by 2 publications

(2 citation statements)

References 62 publications

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“…Incidentally uveitis is noted in the course of various autoimmune diseases [ 9 , 20 , 21 ]. In our study, 1 patient had a history of past recurrent uveitis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of ocular manifestations in systemic sclerosis patients

Waszczykowska¹,

Goś²,

Waszczykowska³

et al. 2013

aoms

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IntroductionSystemic sclerosis (scleroderma, SSc) is a severe chronic connective tissue disease caused by immune system disorders and changes in the structure and functions of blood vessels, which consequently leads to enhanced tissue fibrosis. The aim of the study was to evaluate changes in the organ of vision in systemic sclerosis patients.Material and methodsOverall the study involved 27 patients with systemic sclerosis. The control group comprised 27 age- and gender-matched healthy individuals. All the study subjects underwent complete ophthalmological examination that in systemic sclerosis patients additionally involved fluorescein angiography.ResultsOphthalmological examination revealed higher incidence of the following abnormalities in the study group, compared to the control: symptoms of dry eye syndrome (19 eyes, p < 0.02), astigmatism(in 30 eyes, p < 0.01), posterior subcapsular cataract (10 eyes, p < 0.05), increased intraocular pressure (> 21 mm Hg were observed in 11 eyes, p < 0.002) and vascular abnormalities within fundus in fluorescein angiography (20 eyes).ConclusionsIn patients with systemic sclerosis numerous abnormalities within the vision of organ may be found. Regular ophthalmological examinations are essential among the mentioned group. The examination should be particularly focused on the presence of retinal vascular abnormalities.

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“…Incidentally uveitis is noted in the course of various autoimmune diseases [ 9 , 20 , 21 ]. In our study, 1 patient had a history of past recurrent uveitis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of ocular manifestations in systemic sclerosis patients

Waszczykowska¹,

Goś²,

Waszczykowska³

et al. 2013

aoms

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“…IL-6 and TGF-β induce the differentiation of Th17 cells from naive T cells. A high level of TBX 21 (Th1), RORC (Th17) and Foxp3 (Treg) were confirmed in neuro-BD [ 57 ]. The presence of the IL-21 and IL17-A producing T cells was demonstrated in the cerebrospinal fluid, brain parenchyma inflammatory infiltrates, and intracerebral blood vessels of patients with active BD and central nervous system involvement.…”

Section: Behçet's Diseasementioning

confidence: 99%

Interleukin-17 in human inflammatory diseases

Shabgah

Fattahi

Shahneh

2014

pdia

Self Cite

140

100

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Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. This review introduces the roles of IL-17 and Th17 cells in human autoimmune diseases. Studies have shown that T cells with inflammatory effects on epithelial, endothelial and fibroblast cells express IL-17. Th17 cells are supposed to be involved in various autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Base on the biologic functions and regulation, IL-17 has regulatory roles in host defense and chronic inflammation which result in tissue damage and autoimmunity. So the IL-17 links links innate and adaptive immunity and has both beneficial and pathological effects on the immune system. This paper will focus on the possible roles of IL-17 in autoimmune diseases, a fundamental player in immune regulation.

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Insights into Behçet’s disease

Cited by 2 publications

References 62 publications

Prevalence of ocular manifestations in systemic sclerosis patients

Prevalence of ocular manifestations in systemic sclerosis patients

Interleukin-17 in human inflammatory diseases

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