Insights into biological properties of less explored bark of industrially important Acacia catechu Willd

Kumar, Rajeev; Mahey, Sonia; Arora, Rohit; Mahajan, Jyoti; Kumar, Vinod; Arora, Saroj

doi:10.1016/j.indcrop.2019.111486

Cited by 10 publications

(13 citation statements)

References 44 publications

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“…This TPC also exceeds that obtained from other bark aqueous extracts obtained by various extraction methods (stirring, sonication, microwave-assisted extraction): Fagus sylvatica L. (29-57 mg GAE/g DM), Eucalyptus globulus (181 mg GAE/g DM), Quercus (15 mg GAE/g DM) [48], and Acacia catechu (131 mg GAE/g DM) [49].…”

Section: Compositionmentioning

confidence: 58%

Mimosa tenuiflora Aqueous Extract: Role of Condensed Tannins in Anti-Aflatoxin B1 Activity in Aspergillus flavus

Hernandez

Cadenillas

Maghubi

et al. 2021

Toxins

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Aflatoxin B1 (AFB1) is a potent carcinogenic mycotoxin that contaminates numerous crops pre- and post-harvest. To protect foods and feeds from such toxins without resorting to pesticides, the use of plant extracts has been increasingly studied. The most interesting candidate plants are those with strong antioxidative activity because oxidation reactions may interfere with AFB1 production. The present study investigates how an aqueous extract of Mimosa tenuiflora bark affects both the growth of Aspergillus flavus and AFB1 production. The results reveal a dose-dependent inhibition of toxin synthesis with no impact on fungal growth. AFB1 inhibition is related to a down-modulation of the cluster genes of the biosynthetic pathway and especially to the two internal regulators aflR and aflS. Its strong anti-oxidative activity also allows the aqueous extract to modulate the expression of genes involved in fungal oxidative-stress response, such as msnA, mtfA, atfA, or sod1. Finally, a bio-guided fractionation of the aqueous extract demonstrates that condensed tannins play a major role in the anti-aflatoxin activity of Mimosa tenuiflora bark.

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Section: Compositionmentioning

confidence: 58%

Mimosa tenuiflora Aqueous Extract: Role of Condensed Tannins in Anti-Aflatoxin B1 Activity in Aspergillus flavus

Hernandez

Cadenillas

Maghubi

et al. 2021

Toxins

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“…Moreover, methanol extract of A. catechu showed DPPH radical and ABTS (2,2azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)) radical scavenging activities (IC 50 : 101.74 and 140.41 μg/mL), superoxide radical and peroxyl radical scavenging activities (IC 50 : 175.90 and 152.76 μg/mL), and cupric ion and ferric ion reducing power (IC 50 : 184.30 and 232.13 μg/mL) [36]. Similarly, the methanol, ethanol, butanol, and aqueous fractions of A. catechu showed an antioxidant property with IC 50 ranges of 92.48-529.30 μg/mL on DPPH radical, ABTS radical, superoxide radical scavenging assays, and cupric ion and ferric ion reducing assays mainly due to the presence of quercetin (16), kaempferol (13), and chlorogenic acid (28) (Figure 2) [13].…”

Section: Antidiabetic Activities a Catechu Extracts Show Anmentioning

confidence: 97%

“…e ethanol extract of A. catechu showed concentration-dependent inhibition in the proliferation of human lung (A549), prostate (PC-3), breast (T47D and MCF-7), colon (HCT-16, Colo-205), and leukemia (THP-1, HL-60, and K562) cancer cells with cytotoxicity ranges of 9.0-42.8 μg/mL [75]. Additionally, the ethyl acetate fraction of this plant was responsible for 50% inhibition in the growth of cancer line cells at 153.23 μg/mL in lung cancer cell line (A549), 163.97 μg/mL in cervix cancer cell line (HeLa), 186.19 μg/mL in a prostate cancer cell line (PC-3), 204.67 μg/mL in liver cancer cell line (HepG2), and 251.33 μg/mL in brain cancer cell line (IMR32) [13]. is ethyl acetate fraction has most potent activity towards breast cancer cell line (MCF-7) with an IC 50 of 137.5 μg/mL.…”

Section: Anticancer Activitiesmentioning

confidence: 99%

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

Adhikari

Aryal

Bhattarai

2021

Journal of Chemistry

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With the emergence of epidemics, pandemics, and infectious diseases, several research activities have been carried out on natural products to tackle them. As there are structural diversities in natural products, researchers are focused on exploring them for treatment and/or management of various infections and/or diseases. Acacia catechu (L.f.) Willd. belonging to the order Fabales and family Fabaceae shows a wide range of pharmacological functions in the management of diseases in humankind. This review was carried out to gather and provide information about the chemical constituents and pharmacological activities of A. catechu through the literature survey of scientific articles. On preliminary assessments, A. catechu is demonstrated as a significant wellspring of bioactive compounds with a wide range of biological and pharmaceutical applications such as antidiabetic, antioxidant, antimicrobial, anticancer, antidiarrheal, anti-inflammatory, antiviral, hepatoprotective, immunomodulatory, and so on. Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. Further research on diverse bioactive compounds from the plant is required to develop them as a successful potent drug.

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“…All the compounds displayed LC 50 values higher than ivermectin. The cinnamic acid esters (67)(68)(69)(70), the type of alkyl group, the length of the chain and the degree of branching greatly affected their biological activity. The compounds with potent biological activity were compound 68, 71, 73 and 74.…”

Section: Cinnamic Acid Derivatives With Antiparasitic Activitymentioning

confidence: 99%

“…Free radicals produce damaged membranes, produce DNA nicks and inflict other oxidative injuries. Accumulation of free radicals activates proto oncogenes causing carcinogenesis [70]. There is a need to scavenge free radicals in the body to minimize the damage inflicted by free radicals.…”

Section: Cinnamic Acid Derivatives With Antioxidant and Anti-inflammamentioning

confidence: 99%

Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

280

134

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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Insights into biological properties of less explored bark of industrially important Acacia catechu Willd

Cited by 10 publications

References 44 publications

Mimosa tenuiflora Aqueous Extract: Role of Condensed Tannins in Anti-Aflatoxin B1 Activity in Aspergillus flavus

Mimosa tenuiflora Aqueous Extract: Role of Condensed Tannins in Anti-Aflatoxin B1 Activity in Aspergillus flavus

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

Cinnamic Acid Derivatives and Their Biological Efficacy

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