2021
DOI: 10.21203/rs.3.rs-612871/v1
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Insights into cadmium-induced carcinogenesis through an in-vitro study using C3H10T1/2Cl8 cells: the multifaceted role of mitochondria

Abstract: In this paper we report the metabolic characterization of two foci, F1 and F3, obtained at the end of Cell Transformation Assay (CTA), performed by treating C3H10T1/2Cl8 mouse embryo fibroblasts with 1 µM CdCl2 for 24 h. The elucidation of cadmium action mechanism can be useful both to improve the in vitro CTA and to yield insights into carcinogenesis. We previously showed that, despite being both completely transformed type III foci, F1 and F3 foci display different morphologies, proliferative behaviors and g… Show more

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