Insights into chronic migraine pathophysiology – what measures of gray matter reveal

Reply to letter to the editor: Insights into chronic migraine pathophysiology – what measures of gray matter reveal

“…We appreciate DeSouza et al.’s interest in and comments (1) on our study (2) and find the results from their recent study of great interest (3). In their study, in addition to conventional volume and thickness-based measures, a graph-theoretical approach was used to delineate differences in structural covariance networks between patients with chronic migraine (CM) and healthy controls (HC).…”

“…The authors received no financial support for the research, authorship, and/or publication of this article. Kuan-Lin Lai 1,2,3,4 , David M Niddam 4,5 Jong-Ling Fuh 1,2,4 , Wei-Ta Chen 1,2,4,5 Jaw-Ching Wu 3,6 and Shuu-Jiun Wang 1,2,4…”

The increased iron deposition of the gray matter over the whole brain in chronic migraine: An exploratory quantitative susceptibility mapping study

“…Chronicity of migraine accounts for approximately 2.5% of episodic migraines annually, and its neuromechanism remains unknown. 6 Cerebral gray matter plays an important role in the pathophysiology of CM, 7 and the previous study demonstrated that gray matter was associated with pain sensitivity, 8 which was common in chronic pain. Advanced functional imaging studies have shown that functional connectivity changed in cortex 9,10 and deep nuclei [9][10][11][12][13][14] was altered in both the interictal and ictal phases of migraine, and further structural imaging studies also indicated significantly abnormal gray matter volumes in migraine.…”