Insights into microfabrication and implementation of microfluidics in pharmaceutical drug delivery and analysis

Alawdan, Omnia A.; Sharallah, Omnya A.; Abdelwahab, Nada A.; Mohammed, Alshimaa O.; Elmowafy, Enas; Soliman, Mahmoud E. S.

doi:10.1016/j.onano.2023.100156

Cited by 17 publications

(3 citation statements)

References 198 publications

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“…Tarama, 384 ve 1536 kuyulu mikrotitre plakaları kullanarak günde yüz binlerce veri noktası üretmekten sorumludur (Lyu vd., 2018). Diğer bir seçenek ise, çok az miktarda sıvı kullanan, hızlı analiz ile birden fazla veri noktası oluşturan ve böylece zaman ve laboratuvar alanını azaltan mikroakışkanlardır (Al-wdan vd., 2023). Taramanın amacı, sürecin optimizasyonu ve nihai ürünün aktif ve hızlı bir şekilde teslim edilmesidir (Shukla vd.. 2017;Silva vd.. 2021).…”

Section: Endüstri̇yel Süreçleri̇n Opti̇mi̇zasyonuunclassified

Premature Ovarian Insufficiency (POI): A Current Overview of Diagnosis, Etiopathology, Epidemiology, Symptomatology, and Treatment Options

Korkmaz

2023

Sağlık Bilimleri Araştırmaları: Temel Tıp-Iii

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Premature Ovarian Insufficiency (POI) is a pathological condition characterized by the cessation of ovarian function prior to an individual attaining the age of 40 years. This syndrome is marked by elevated levels of gonadotropins and diminished levels of oestrogen, ultimately leading to infertility. According to guidelines provided by the European Society for Human Reproduction and Embryology (ESHRE), diagnostic criteria for this condition include increased follicle-stimulating hormone (FSH) levels exceeding 25 IU/l tested on two separate occasions with a four-week interval between each measurement, together with the presence of amenorrhea or oligomenorrhea for at least 4 months. The occurrence of POI has been associated with adverse effects such as reduced fertility, irregular menstrual cycles, failed pregnancies, and a reduction in overall health-related quality of life. The early decline in oestrogen puts women at increased risk of osteoporosis, hypertension, cardiovascular disease, weight gain, type 2 diabetes, cognitive disorders such as Parkinson's, depression, and Alzheimer's disease, and dementia. In this respect, it has important consequences that negatively affect women. However, genetic abnormalities, metabolic problems, autoimmunity, iatrogenic causes, infections, or environmental variables have been identified that contribute to the development of premature ovarian failure syndrome in some patients. The etiopathogenesis of the disease remains largely unknown in the majority of cases. This review aims to review the available literature, focusing on the diagnosis, clinical aspects, causes, symptoms, complications, and treatment of POI.

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Section: Endüstri̇yel Süreçleri̇n Opti̇mi̇zasyonuunclassified

Premature Ovarian Insufficiency (POI): A Current Overview of Diagnosis, Etiopathology, Epidemiology, Symptomatology, and Treatment Options

Korkmaz

2023

Sağlık Bilimleri Araştırmaları: Temel Tıp-Iii

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Section: Endüstri̇yel Süreçleri̇n Opti̇mi̇zasyonuunclassified

Sağlık Bilimleri Araştırmaları: Temel Tıp-III

Cengiz,

Ekim,

Ekim

et al. 2023

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Değerli okuyucularımız; Sağlık bilimleri alanında özveri ile çalışan akademisyenlerimizin büyük emekleri ile hazırladığımız kitabımız, geniş kapsamlı bir yaklaşım ile bizlere güncel bilgiler sunmaktadır. Tıpta temel bilimler ile klinik bilimler birlikte çalışarak sürekli önemli gelişmeler kaydetmektedir. Konular üzerinde araştırma yaparken ona birçok bakış açısı ile bakarak yaklaşmamız, ayrıntıları fark etmemize, yeni fikirler ve çözümler üretmemize katkı sağlamaktadır. Kitabın zengin içeriği ve perspektifi ile yazarlarımızın bilim dünyasına katkı sunan yorumlarının, bilime gönül veren insanlar için yararlı olacağını umut etmekteyim. Hastalıkların önlenmesi, erken tanısı ve etkin tedavisi için bilimsel alanlarda sabırla çalışan yol arkadaşlarımın çalışmalarına yeni ufuklar açmasını dilerim. Kitabımıza destek veren yazar kadromuz ve her seferinde aynı heyecan ile hazırladığımız yeni eserlerde büyük çabalarından dolayı yayın ekibimize teşekkür ederim. Prof. Dr. Hülya Çiçek

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“…These devices can accurately simulate various parts of the body based on their specific designs. They can demonstrate the effects of different substances, drugs, and mechanisms 20 . These simulated platforms, by better simulating physiological conditions and better drug efficiency prediction using sophisticated in vitro models, have bridged the gap between data from animal and human studies 21 – 23 .…”

Section: Introductionmentioning

confidence: 99%

Evaluating the antioxidant potential of resveratrol-gold nanoparticles in preventing oxidative stress in endothelium on a chip

Fayazbakhsh,

Hataminia,

Eslam

et al. 2023

Sci Rep

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Vascular endothelial cells play a vital role in the health and maintenance of vascular homeostasis, but hyperglycemia disrupts their function by increasing cellular oxidative stress. Resveratrol, a plant polyphenol, possesses antioxidant properties that can mitigate oxidative stress. Addressing the challenges of its limited solubility and stability, gold nanoparticles (GNps) were utilized as carriers. A microfluidic chip (MFC) with dynamic flow conditions was designed to simulate body vessels and to investigate the antioxidant properties of resveratrol gold nanoparticles (RGNps), citrate gold nanoparticles (CGNps), and free Resveratrol on human umbilical vein endothelial cells (HUVEC). The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay was employed to measure the extracellular antioxidant potential, and cell viability was determined using the Alamar Blue test. For assessing intracellular oxidative stress, the 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) assay was conducted, and results from both the cell culture plate and MFC were compared. Free Resveratrol demonstrated peak DPPH scavenging activity but had a cell viability of about 24–35%. RGNPs, both 3.0 ± 0.5 nm and 20.2 ± 4.7 nm, consistently showed high cell viability (more than about 90%) across tested concentrations. Notably, RGNPs (20 nm) exhibited antioxidative properties through DPPH scavenging activity (%) in the range of approximately 38–86% which was greater than that of CGNps at about 21–32%. In the MFC,the DCFH-DA analysis indicated that RGNPs (20 nm) reduced cellular oxidative stress by 57–82%, surpassing both CGNps and free Resveratrol. Morphologically, cells in the MFC presented superior structure compared to those in traditional cell culture plates, and the induction of hyperglycemia successfully led to the formation of multinucleated variant endothelial cells (MVECs). The MFC provides a distinct advantage in observing cell morphology and inducing endothelial cell dysfunction. RGNps have demonstrated significant potential in alleviating oxidative stress and preventing endothelial cell disorders.

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Insights into microfabrication and implementation of microfluidics in pharmaceutical drug delivery and analysis

Cited by 17 publications

References 198 publications

Premature Ovarian Insufficiency (POI): A Current Overview of Diagnosis, Etiopathology, Epidemiology, Symptomatology, and Treatment Options

Premature Ovarian Insufficiency (POI): A Current Overview of Diagnosis, Etiopathology, Epidemiology, Symptomatology, and Treatment Options

Sağlık Bilimleri Araştırmaları: Temel Tıp-III

Evaluating the antioxidant potential of resveratrol-gold nanoparticles in preventing oxidative stress in endothelium on a chip

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