Insights into mineral fibre-induced lung epithelial cell toxicity and pulmonary fibrosis

Jablonski, R.; Kim, Seokjo; Cheresh, Paul; Liu, Gang; Kamp, David W.

doi:10.1180/emu-notes.18.14

Cited by 10 publications

(17 citation statements)

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“…The major ARDs are asbestosis, lung cancer, and malignant mesothelioma. Lung cancer/abnormalities may include pleural abnormalities, bronchogenic carcinomas including squamous cell carcinomas, small- and large-cell carcinoma, and adenocarcinomas [ 5 ]. In occupationally exposed cohorts, the excess of lung cancer may be greater than that of mesothelioma [ 6 , 7 ], but in communities ARD risk is primarily indicated by mesothelioma.…”

Section: Introductionmentioning

confidence: 99%

Asbestos in High-Risk Communities: Public Health Implications

Emmett

2021

IJERPH

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Asbestos-related diseases (ARDs)—mesothelioma, lung cancer, and asbestosis—are well known as occupational diseases. As industrial asbestos use is eliminated, ARDs within the general community from para-occupational, environmental, and natural exposures are more prominent. ARD clusters have been studied in communities including Broni, Italy; Libby, Montana; Wittenoom, Western Australia; Karain, Turkey; Ambler, Pennsylvania; and elsewhere. Community ARDs pose specific public health issues and challenges. Community exposure results in higher proportions of mesothelioma in women and a younger age distribution than occupational exposures. Exposure amount, age at exposure, fiber type, and genetic predisposition influence ARD expression; vulnerable groups include those with social and behavioral risk, exposure to extreme events, and genetic predispositions. To address community exposure, regulations should address all carcinogenic elongated mineral fibers. Banning asbestos mining, use, and importation will not reduce risks from asbestos already in place. Residents of high-risk communities are characteristically exposed through several pathways differing among communities. Administrative responsibility for controlling environmental exposures is more diffuse than for workplaces, complicated by diverse community attitudes to risk and prevention and legal complexity. The National Mesothelioma Registries help track the identification of communities at risk. High-risk communities need enhanced services for screening, diagnosis, treatment, and social and psychological support, including for retired asbestos workers. Legal settlements could help fund community programs. A focus on prevention, public health programs, particularization to specific community needs, and participation is recommended.

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Section: Introductionmentioning

confidence: 99%

Asbestos in High-Risk Communities: Public Health Implications

Emmett

2021

IJERPH

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“…Although the aetiology of mineral fibre-related diseases has been the subject of extensive studies [1,14,[20][21][22][23], the actual mechanisms by which these particles induce adverse effects in vivo are not fully understood to date. However, much progress has been made in identifying the properties of mineral fibres that make them cyto-genotoxic agents [24].…”

Section: Introductionmentioning

confidence: 99%

“…Overall, the toxicity mechanism of mineral fibres is linked to several cell-fibre interactions that are regulated by complex cell processes and intercellular relationships investigated through in vitro and in vivo models [20][21][22][23][31][32][33][34][35][36][37][38][39][40]. In vitro and in vivo bioassays provide reliable information on the cellular and tissue response following exposure to hazardous mineral fibre.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Fibrous Wollastonite NYAD G in View of Its Use as Negative Standard for In Vitro Toxicity Tests

et al. 2021

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Today, despite considerable efforts undertaken by the scientific community, the mechanisms of carcinogenesis of mineral fibres remain poorly understood. A crucial role in disclosing the mechanisms of action of mineral fibres is played by in vitro and in vivo models. Such models require experimental design based on negative and positive controls. Commonly used positive controls are amosite and crocidolite UICC standards, while negative controls have not been identified so far. The extensive characterisation and assessment of toxicity/pathogenicity potential carried out in this work indicate that the commercial fibrous wollastonite NYAD G may be considered as a negative standard control for biological and biomedical tests involving mineral fibres. Preliminary in vitro tests suggest that wollastonite NYAD G is not genotoxic. This material is nearly pure and is characterized by very long (46.6 µm), thick (3.74 µm) and non-biodurable fibres with a low content of metals. According to the fibre potential toxicity index (FPTI) model, wollastonite NYAD G is an inert mineral fibre that is expected to exert a low biological response during in vitro/in vivo testing.

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“…Asbestos amphiboles are less important industrially [10]. Asbestos and elongate mineral particles can cause asbestosis, pleural abnormalities, bronchogenic carcinomas, and mesothelioma [11][12][13]. Symptoms do not appear within a short period of time with the incubation period being 25 to 40 years for pulmonary asbestosis and 15 to 30 years for lung cancer, depending on the intake of asbestos [14,15].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Asbestos-Containing Materials Using Various Test Methods

2020

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The advantages of X-ray powder diffraction (XRPD) analysis are its non-destructive nature, reliability, fast and easy sample preparation, and low costs. XRPD analysis has been used for mineral identification and the quantitative/qualitative determination of various types of fibrous minerals in asbestos-containing materials (ACMs). In order to test the detection limit of ACMs by XRPDD, standard samples with various concentrations of ACMs (0.1%, 1%, and 3%) were fabricated using three matrix materials (talc, vermiculite, and sepiolite). Asbestiform tremolite and chrysotile were identified in the XRPD profiles of the samples with 1% and 3% ACMs. Their integral intensities were positively correlated with the concentrations. However, the XRPD peak of asbestos was not found in the samples with 0.1% ACMs. Therefore, scanning and transmission electron microscopy were utilized to investigate the samples with a very low concentration of ACMs. Although the ACM concentration (0.1%) was negligible and its direct observation was time-consuming, electron microscopy allowed for the detection of asbestos in several matrix materials. Thus, a combination of XRPD and electron microscopy improve analytical performance and data reliability.

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Insights into mineral fibre-induced lung epithelial cell toxicity and pulmonary fibrosis

Cited by 10 publications

References 0 publications

Asbestos in High-Risk Communities: Public Health Implications

Asbestos in High-Risk Communities: Public Health Implications

Characterization of Fibrous Wollastonite NYAD G in View of Its Use as Negative Standard for In Vitro Toxicity Tests

Quantitative Analysis of Asbestos-Containing Materials Using Various Test Methods

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