Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism

Nie, Miaomiao; Ni, Weilin; Wang, Lihan; Gao, Qiang; Liú, Dan; Tian, Fei; Wang, Zhenji; Zhang, Cunfang; Qi, Di

doi:10.3389/fgene.2022.903995

Cited by 4 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skeletal muscle protein deposition or growth is a dynamic process of continuous protein synthesis and degradation, and in addition to synthesis, proteolysis is also an important pathway. In fish, ubiquitin-mediated proteolysis is one of the important protein degradation pathways in cells, and this mechanism mainly involves the binding of small ubiquitin proteins to proteins to form ubiquitin–protein complexes, which are then recognized and degraded by degradative enzymes [ 54 ]. In ubiquitin-mediated protein degradation, the binding of ubiquitin to target proteins requires the involvement of a series of enzymes such as ubiquitin ligases (E1), ubiquitin carrier proteins (E2), and ubiquitin-conjugated target proteins (E3).…”

Section: Discussionmentioning

confidence: 99%

Biochemical, Histological, and Transcriptomic Analyses Reveal Underlying Differences in Flesh Quality between Wild and Farmed Ricefield Eel (Monopterus albus)

Yang,

Yuan,

Rahman

et al. 2024

Foods

View full text Add to dashboard Cite

The present study aimed to systematically investigate the underlying differences in flesh quality between wild and farmed Monopterus albus. Fifteen healthy M. albus per group with an average body weight of 45 g were sampled to analyze muscle parameters by biochemical indicators, histomorphology, and molecular biology. Compared with the wild fish, the farmed M. albus in flesh had lower crude protein, collagen, lysine, histidine, total amino acids, SFA, n-3 PUFA contents, and n-3/n-6 ratio (p < 0.05), and higher moisture, crude lipid, crude ash, MUFA, n-6PUFA, and total PUFA contents (p < 0.05). The thawing loss, drip loss, steaming loss, and boiling loss in the farmed group were significantly higher, and hardness, springiness, cohesiveness, gumminess, chewiness, and resilience were significantly lower than those in the wild group (p < 0.05). In addition, higher muscle fiber density and lower muscle fiber diameter were observed in wild M. albus (p < 0.05). In muscle transcriptome profiling, differentially expressed genes and enriched pathways are primarily associated with muscle development, protein synthesis, catabolism, lipid metabolism, and immunity. To the best of our knowledge, this is the first investigation that compares the flesh quality between wild and farmed M. albus in terms of biochemistry, histology, and molecular biology levels. Overall, wild M. albus had a higher nutritional value and texture quality than farmed M. albus.

show abstract

Section: Discussionmentioning

confidence: 99%

Biochemical, Histological, and Transcriptomic Analyses Reveal Underlying Differences in Flesh Quality between Wild and Farmed Ricefield Eel (Monopterus albus)

Yang,

Yuan,

Rahman

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

Toward new biomarkers of cold tolerance: microRNAs regulating cold adaptation in fish are differentially expressed in cold-tolerant and cold-sensitive Nile tilapia (Oreochromis niloticus)

Blödorn,

Martins,

Dellagostin

et al. 2024

Aquaculture

View full text Add to dashboard Cite

Runs of Homozygosity Decipher Genetic Diversity in Cattle Breed Dwelling in the Colder Regions of the World

Mahar,

Goli,

Chishi

et al. 2024

Cytogenet Genome Res

View full text Add to dashboard Cite

Background Our study focuses on Yakutian cattle, a Siberian native breed, examining its inbreeding and diversity through genome-wide analysis of Runs of Homozygosity (ROH). Yakutian cattle are adapted to Siberia's harsh sub-arctic conditions, enduring temperatures below −70°C. However, the population genetics studies on this breed are scanty, to document the genetic uniqueness in this cattle. Results We analyzed 40 Yakutian cattle with strict quality control for ROH detection yielding 683 homozygous segments, averaging to 17 per individual with an average length of 9 Mb. ROH regions were found to be involved in important pathways pertaining to cold adaptation. Autozygosity ranged from 1% to 12% of the genome, with a relatively low average inbreeding coefficient (FROH) of 0.057309, as compared to other breeds. Also, the different diversity indicators namely, principal component analysis, heterozygosity and effective population size analysis revealed prevalence of genetic diversity within the breed. Conclusion Our findings on ROH are first of its kind in Yakutian cattle that support their adaptability to colder environments, as evidenced by low inbreeding and high genetic diversity.

show abstract

Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism

Cited by 4 publications

References 51 publications

Biochemical, Histological, and Transcriptomic Analyses Reveal Underlying Differences in Flesh Quality between Wild and Farmed Ricefield Eel (Monopterus albus)

Biochemical, Histological, and Transcriptomic Analyses Reveal Underlying Differences in Flesh Quality between Wild and Farmed Ricefield Eel (Monopterus albus)

Toward new biomarkers of cold tolerance: microRNAs regulating cold adaptation in fish are differentially expressed in cold-tolerant and cold-sensitive Nile tilapia (Oreochromis niloticus)

Runs of Homozygosity Decipher Genetic Diversity in Cattle Breed Dwelling in the Colder Regions of the World

Contact Info

Product

Resources

About