Insights into molecular mechanisms of chemotherapy resistance in cancer

Kar, Animesh; Agarwal, Shivam; Singh, Agrata; Bajaj, Avinash; Dasgupta, Ujjaini

doi:10.1016/j.tranon.2024.101901

Cited by 10 publications

(3 citation statements)

References 95 publications

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“…This phenomenon is the key factor for relapse and mortality among cancer patients [52]. Resistance to chemotherapy involves several mechanisms, including enhanced drug efflux from cells [53]. This process is facilitated by membrane transporter proteins such as MDR1, also termed permeability glycoprotein (P-glycoprotein, P-gp) or ATP-binding cassette subfamily B member 1, and MRP1, also known as ATP-binding cassette subfamily C member 1.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, by day 10, the average spheroid sizes of LNCaP, DU-145, and PC3 cells exceeded 100 µm. Spheroids larger than approximately 100 µm are known to harbor an internal hypoxic zone owing to restricted oxygen, nutrient, and metabolite distribution, leading to the formation of a necrotic core [53,54]. This hypoxic tumor microenvironment is pivotal in mediating drug resistance via specific cellular signaling pathways and influences the resistance of CSCs to chemotherapy and radiotherapy [55].…”

Section: Discussionmentioning

confidence: 99%

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A Marine Collagen-Based 3D Scaffold for In Vitro Modeling of Human Prostate Cancer Niche and Anti-Cancer Therapeutic Discovery

Song,

Lim,

Kim

et al. 2024

Marine Drugs

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Recently, the need to develop a robust three-dimensional (3D) cell culture system that serves as a valuable in vitro tumor model has been emphasized. This system should closely mimic the tumor growth behaviors observed in vivo and replicate the key elements and characteristics of human tumors for the effective discovery and development of anti-tumor therapeutics. Therefore, in this study, we developed an effective 3D in vitro model of human prostate cancer (PC) using a marine collagen-based biomimetic 3D scaffold. The model displayed distinctive molecular profiles and cellular properties compared with those of the 2D PC cell culture. This was evidenced by (1) increased cell proliferation, migration, invasion, colony formation, and chemoresistance; (2) upregulated expression of crucial multidrug-resistance- and cancer-stemness-related genes; (3) heightened expression of key molecules associated with malignant progressions, such as epithelial–mesenchymal transition transcription factors, Notch, matrix metalloproteinases, and pluripotency biomarkers; (4) robust enrichment of prostate cancer stem cells (CSCs); and (5) enhanced expression of integrins. These results suggest that our 3D in vitro PC model has the potential to serve as a research platform for studying PC and prostate CSC biology, as well as for screening novel therapies targeting PC and prostate CSCs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Marine Collagen-Based 3D Scaffold for In Vitro Modeling of Human Prostate Cancer Niche and Anti-Cancer Therapeutic Discovery

Song,

Lim,

Kim

et al. 2024

Marine Drugs

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show abstract

“…Currently, some major chemotherapy drugs like cisplatin, DOCE, and DOX have been reported to exhibit resistance, with complex resistance mechanisms ( Kar et al, 2024 ). There is growing evidence supporting ferroptosis as a significant mechanism of chemotherapy resistance.…”

Section: Combination Therapy In Cancer Treatment To Enhance Efficacy ...mentioning

confidence: 99%

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

Zhou,

Nan,

et al. 2024

Front. Pharmacol.

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Over the past few years, there has been a gradual increase in the incidence of cancer, affecting individuals at younger ages. With its refractory nature and substantial fatality rate, cancer presents a notable peril to human existence and wellbeing. Hawthorn, a medicinal food homology plant belonging to the Crataegus genus in the Rosaceae family, holds great value in various applications. Due to its long history of medicinal use, notable effects, and high safety profile, hawthorn has garnered considerable attention and plays a crucial role in cancer treatment. Through the integration of modern network pharmacology technology and traditional Chinese medicine (TCM), a range of anticancer active ingredients in hawthorn have been predicted, identified, and analyzed. Studies have shown that ingredients such as vitexin, isoorientin, ursolic acid, and maslinic acid, along with hawthorn extracts, can effectively modulate cancer-related signaling pathways and manifest anticancer properties via diverse mechanisms. This review employs network pharmacology to excavate the potential anticancer properties of hawthorn. By systematically integrating literature across databases such as PubMed and CNKI, the review explores the bioactive ingredients with anticancer effects, underlying mechanisms and pathways, the synergistic effects of drug combinations, advancements in novel drug delivery systems, and ongoing clinical trials concerning hawthorn’s anticancer properties. Furthermore, the review highlights the preventive health benefits of hawthorn in cancer prevention, offering valuable insights for clinical cancer treatment and the development of TCM with anticancer properties that can be used for both medicinal and edible purposes.

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The roles of lncRNAs in the development of drug resistance of oral cancers

Wang,

Liu,

2024

Biomedicine & Pharmacotherapy

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Insights into molecular mechanisms of chemotherapy resistance in cancer

Cited by 10 publications

References 95 publications

A Marine Collagen-Based 3D Scaffold for In Vitro Modeling of Human Prostate Cancer Niche and Anti-Cancer Therapeutic Discovery

A Marine Collagen-Based 3D Scaffold for In Vitro Modeling of Human Prostate Cancer Niche and Anti-Cancer Therapeutic Discovery

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

The roles of lncRNAs in the development of drug resistance of oral cancers

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