Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Sun, Tianjing; Li, Mo; Liu, Qi; Yu, Anyong; Cheng, Kun; Ma, Jianxing; Murphy, Sean; McNutt, Patrick Michael; Zhang, Yuanyuan

doi:10.1007/s11684-023-1031-9

Cited by 8 publications

(6 citation statements)

References 186 publications

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“…Exosomes are small extracellular vesicles secreted by various stem cells and are potent mediators of intercellular communication and tissue repair [ 166 , 247 ]. Recently, clinical applications of exosomes in general surgery, neurosurgery, cardiothoracic surgery, orthopedic surgery, head and neck surgery, plastic surgery, acute skin wound healing, urology, ophthalmology, and obstetrics and gynecology, and other diseases induced by ischemia, inflammation, or cancer were suggested [ 248 , 249 ].…”

Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

“…Curiously, in a mouse model of preeclampsia, it was reported that nicotine has favorable modifications of the trophoblast-derived exosomes [ 251 ]. Exosomes, by carrying genetic material such as microRNAs, can regulate cell function and may not only serve as a biomarker of disease state but may also be of therapeutic potential [ 247 , 248 , 249 ]. Therefore, it is of high interest and applicability to determine whether nAChRs may have a role in exosome production and/or effect, particularly in relation to neurodegenerative diseases.…”

Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

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Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Cells

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Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease. It has been well established that neuronal nicotinic cholinergic receptors (nAChRs) can regulate DA release and that nicotine itself may have neuroprotective effects. Recent studies identified nAChRs in nonneuronal cell types, including glial cells, where they may regulate inflammatory responses. Given the crucial role of neuroinflammation in dopaminergic degeneration and the involvement of microglia and astrocytes in this response, glial nAChRs may provide a novel therapeutic target in the prevention and/or treatment of PD. In this review, following a brief discussion of PD, we focus on the role of glial cells and, specifically, their nAChRs in PD pathology and/or treatment.

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Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

Section: Nachrs–ng2 Cellsmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Cells

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“…However, this administration method is somewhat cumbersome and carries a risk of infection. Further research is necessary to optimize EV therapy, not only in the areas of isolation methods and engineering but also in determining the optimal dose, timing, administration, and frequency of EV therapy [ 181 ]. Maintaining a sustained, effective EV concentration is crucial for effective wound healing [ 181 ].…”

Section: Extracellular Vesicles-loaded Microneedles: a Promising Dire...mentioning

confidence: 99%

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Wang,

Cheng,

2024

Pharmaceutics

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Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential for facilitating effective drug delivery, vaccination, and targeted sample extraction. Extracellular vesicles (EVs), serving as cargo for MNs, are naturally occurring nanovesicles secreted by cells and characterized by novel biomarkers, low immunogenicity, and cell-source-specific traits. MNs prove instrumental in extracting EVs from the sample fluid, thereby facilitating a promising diagnostic and prognostic tool. To harness the therapeutic potential of EVs in tissue repair, MNs with sustained delivery of EVs leverage micron-sized channels to enhance targeted site concentration, demonstrating efficacy in treating various diseases, such as Achillea tendinopathy, hair loss, spinal cord injury, and diabetic ulcers. EV-loaded MNs emerge as a promising platform for repair applications of skin, cardiac, tendon, hair, and spinal cord tissues. This review commences with an overview of MNs, subsequently delving into the role of EVs as cargo for MNs. The paper then synthesizes the latest advancements in the use of EV-loaded MNs for tissue regenerative repair, extending to research progress in extracting EVs from MNs for disease diagnosis and prognostic evaluations. It aims to offer valuable insights and forecast future research trajectories with the hope of inspiring innovative ideas among researchers in this field.

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“…Exosomes are small extracellular vesicles secreted by various stem cells and are potent mediators of intercellular communication and tissue repair [213][214]. Indeed, clinical applications of exosomes in general surgery, neurosurgery, orthopedic surgery, head and neck surgery, cardiothoracic surgery, plastic surgery, acute skin wound healing, urology, ophthalmology, and obstetrics and gynecology, and other diseases induced by cancer, ischemia, or inflammation have been suggested [215] [216]. Whether their application in MDD may also be viable awaits further investigation.…”

Section: Ng2 Cells -Depressionmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Cited by 8 publications

References 186 publications

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Role of Glial Cells in Depression and Drug Addiction

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