Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

Xie, Meng; Dart, Dafydd Alwyn; Owen, Sioned; Xi, Wen; Ji, Jiafu; Jiang, Wen Guo

doi:10.3892/or.2016.4908

Cited by 20 publications

(22 citation statements)

References 94 publications

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“…It can interact with miRNA to participate in the expression of the target gene. A large number of studies have shown that miR-21 is highly expressed in gastric cancer, and its expression is associated with the invasion and metastasis of the tumor [9,10].…”

Section: Introductionmentioning

confidence: 99%

The Long Noncoding RNA, Growth Arrest-Specific 5, Suppresses Gastric Cancer by Downregulating miR-21 Expression

Peng

Wang

et al. 2020

Pharmacology

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Background: Gastric cancer has become the second major cause of cancer death. The aim of the present study was to explore the relationship between miR-21 and the long noncoding RNA growth arrest-specific 5 (GAS5) in gastric cancer and the effect on gastric cancer cells. Methods: The expression of miR-21 and GAS5 mRNA was analyzed by quantitative real-time-PCR. Overexpression of GAS5 was used to investigate the biological functions of GAS5 in cells. The cell proliferation was detected by cell counting kit-8 assay and the cell migration and invasion were detected by Transwell. Cell apoptosis was evaluated by Annexin V-FITC/PI staining and apoptosis-related proteins were detected by western blot. The mechanism of GAS5 in vivo was evaluated by the tumorigenesis of nude mice, and dual luciferase reporter was used to determine if miR-21 is a GAS5 target. The inhibition of miR-21 and the simultaneous overexpression of GAS5 and miR-21 were further performed, and the above indicators were detected again. Results: GAS5 was low expression and miR-21 was high expression in gastric cancer tissues and cells. GAS5 overexpression reduced the proliferation, migration, and invasion of gastric cancer cells and increased the apoptosis of gastric cancer cells. The growth rate of GAS5 group slowed down and the volume of tumor decreased. miR-21 is a GAS5 target and GAS5 inhibits the proliferation of gastric cancer cells by targeting miR-21. Conclusion: Our research shown that overexpression of GAS5 can significantly inhibit the proliferation, migration, invasion and tumor formation of gastric cancer cells, and promote the apoptosis of gastric cancer cells, which may be related to the targeting inhibition of miR-21 expression by GAS5.

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Section: Introductionmentioning

confidence: 99%

The Long Noncoding RNA, Growth Arrest-Specific 5, Suppresses Gastric Cancer by Downregulating miR-21 Expression

Peng

Wang

et al. 2020

Pharmacology

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“…8,11,12 For instance, Wu et al 13 indicated that miR-429 can attenuate the migratory and invasive ability of BC cells. Another study conducted by Xie et al 10 demonstrated that miR-1 is associated with the viability, migration, and invasion of gastric cancer cells.…”

Section: Introductionmentioning

confidence: 99%

“…It binds to the 3′ untranslated region (UTR) of target messenger RNAs (mRNAs) and affects the corresponding transcription process. 4,10 The aberrant expression of miRs is often observed in various human malignancies and growing processes, suggesting that miRs play a pivotal role in the metastasis and invasion of carcinoma (mostly working as oncogene suppressors). 8,11,12 For instance, Wu et al 13 indicated that miR-429 can attenuate the migratory and invasive ability of BC cells.…”

Section: Introductionmentioning

confidence: 99%

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

et al. 2017

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We attempted to analyze the effects of miR-1-3p and CCL2 on the proliferation, migration, and invasion of bladder cancer cells. A total of 18 pairs of bladder cancer tissues with corresponding adjacent tissues and the 6 cases of normal tissues were collected. The expressions of miR-1-3p and CCL2 in the cancer tissues were evaluated using quantitative real-time polymerase chain reaction and western blot. The relationship between miR-1-3p and CCL2 was assessed using luciferase reporter assay. The UM-UC-3 bladder cancer cells were transfected with CCL2 small interfering RNA and miR-1-3p mimics. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, wound healing assay, Transwell assay, and the flow cytometry test were used to detect the proliferation, migration, invasion, and apoptosis of bladder cancer cells. Bladder cancer tissues had lower levels of miR-1-3p but higher levels of CCL2 than normal tissues (p < 0.05). The transfection of miR-1-3p mimics and CCL2 small interfering RNA remarkably suppressed cell proliferation and invasion and promoted apoptosis of cells (p < 0.05). Results of the luciferase reporter gene assay demonstrated that miR-1-3p targeted CCL2. MiR-1-3p suppresses the proliferation and invasion of urinary bladder cancer cells by targeting CCL2.

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“…Some miRNAs, regarded as potential therapeutic targets, have also had been reviewed elsewhere. [94][95][96] Our review focused more on discussing miRNAs that are more promising for clinical use. We believe that miRNAs that have an effect on GC treatment (including chemotherapy, targeted therapy, immunotherapy, and others) could also become core targets in microRNA-based therapies.…”

Section: Microrna-based Other Therapiesmentioning

confidence: 99%

<p>Research Progress in microRNA-Based Therapy for Gastric Cancer</p>

Zhao

Shi

et al. 2019

OTT

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Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic therapy is still an urgent problem to overcome. In the past decade, the essential roles of microRNAs (miRNAs) in tumor treatment have been increasingly recognized. In particular, miRNAs were recently shown to reverse the resistance to chemotherapy drugs such as 5-fluorouracil, cisplatin, and doxorubicin. Synthesized nanoparticles loaded with mimics or inhibitors of miRNAs can directly target tumor cells to suppress their growth. Moreover, exosomes may serve as promising safe carriers for mimics or inhibitors of miRNAs to treat GC. Some miRNAs have also been shown to play roles in the mechanism of action of other anti-tumor drugs. Therefore, in this review, we highlight the research progress on microRNA-based therapy in GC and discuss the challenges and prospects associated with this strategy. We believe that microRNA-based therapy has the potential to offer a clinical benefit to GC patients, and this review would contribute to and motivate further research to promote this field toward this ultimate goal.

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Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

Cited by 20 publications

References 94 publications

The Long Noncoding RNA, Growth Arrest-Specific 5, Suppresses Gastric Cancer by Downregulating miR-21 Expression

The Long Noncoding RNA, Growth Arrest-Specific 5, Suppresses Gastric Cancer by Downregulating miR-21 Expression

MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression

<p>Research Progress in microRNA-Based Therapy for Gastric Cancer</p>

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