Insights into the ameliorative effect of oleic acid in rejuvenating phenylhydrazine induced oxidative stress mediated morpho-functionally dismantled erythrocytes

Banerjee, Adrita; Dey, Tiyasa; Ghosh, Arnab; Mishra, Sanatan; Bandyopadhyay, Debasish; Chattopadhyay, Aindrila

doi:10.1016/j.toxrep.2020.10.022

Cited by 7 publications

(5 citation statements)

References 91 publications

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“…Many illnesses, including hematological abnormalities, have oxidative stress as a major contributing factor in their origin, as is well known [35]. Hemolytic anaemia is caused by a variety of harmful cellular processes, including membrane lipid peroxidation and protein oxidation, which erode the integrity of RBC membranes and are caused by the autoxidation of PHZ [36].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of haematinic activity of <i>Tapinanthus globiferus</i> (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats

Asogwa,

Okolo,

Asogwa

et al. 2024

J. Pharm Bio.

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Anaemia is a leading cause of morbidity and mortality in both males and females of all ages. Anaemia was induced by intraperitoneal (i.p.) administration of phenylhydrazine (60 mg/kg) for a period of 3 days. Anaemic rats were allotted to five (5) groups; group I served as the negative control, group II served as the positive control received Astyfer syrup (0.15 mg/kg p.o) , groups III-V served as the test groups that received Tapinanthus globiferus methanol extract, ethyl acetate and n-hexane fractions (100, 200 and 400 mg/kg, p.o.), respectively. Packed cell volume (PCV), haemoglobin concentration (HB) and red blood cell count (RBC) were analysed as indices of anaemia at 7-day intervals for 21 days. The mean cell volume (MCV) and mean cell haemoglobin concentration (MCHC) were calculated accordingly. Leaf extract and fractions of Tapinanthus globiferus significantly (P<0.001) increased the PCV, the HB concentration and the RBC, which had been originally decreased by phenylhydrazine (P<0.001) administration within one week of treatment. The extract and fractions were compared with rats administered with the positive and vehicle-treated group. The results suggested that Tapinanthus globiferus leaves have haematinicactivities.

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Section: Discussionmentioning

confidence: 99%

Evaluation of haematinic activity of <i>Tapinanthus globiferus</i> (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats

Asogwa,

Okolo,

Asogwa

et al. 2024

J. Pharm Bio.

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“…In this regard, Berköz et al ( 2021 ) confirmed the capacity of OLE to decrease lipid peroxide in the RBC membrane, which reduces hemolysis and prolongs their life span. Moreover, Banerjee et al ( 2020 ) verified the high efficiency of oleic acid, a major component of OLE based on GC–MS analysis, in safeguarding the morphology, intracellular antioxidant status, and the metabolic enzyme activities of erythrocytes via its antioxidant mechanisms. Furthermore, the higher amount of bioactive compounds like phytol in both OLE and MLE, with their high antioxidant capacity, could be responsible for counteracting PTL-induced normocytic normochromic anemia (P Costa et al 2016 ; Santos et al 2013 ; Usman et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

Fadil

Behairy

Ebraheim

et al. 2023

Environ Sci Pollut Res

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This study investigated the possible protective role of mulberry leaf (MLE) and olive leaf (OLE) ethanolic extracts against paracetamol (PTL)–induced liver injury in rats compared to silymarin as a reference drug. Initially, MLE and OLE were characterized using gas chromatography–mass spectrometry (GC/MS). Then, forty male Sprague Dawley rats were divided into five groups: the negative control group orally received distilled water for 35 days, the PTL-treated group (PTG) received 500 mg PTL/kg b. wt. for 7 days, the MLE-treated group (MLTG) received 400 mg MLE/kg b. wt., the OLE-treated group (OLTG) received 400 mg OLE/kg b. wt., and the silymarin-treated group (STG) received 100 mg silymarin/kg b. wt. The last three groups received the treatment for 28 days, then PTL for 7 days. The GC–MS characterization revealed that MLE comprised 19 constituents dominated by ethyl linoleate, phytol, hexadecanoic acid, ethyl ester, and squalene. Moreover, OLE comprised 30 components, and the major components were 11-eicosenoic acid, oleic acid, phytol, and à-tetralone. MLE and OLE significantly corrected the PTL-induced normocytic normochromic anemia, leukocytosis, hypercholesterolemia, and hypoproteinemia. Moreover, the MLE and OLE pretreatment considerably suppressed the PTL-induced increment in serum levels of hepatic enzymes, including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. Furthermore, the PTL-induced depletion in antioxidant enzymes, including glutathione peroxidase, superoxide dismutase, and catalase, and the rise in hepatic malondialdehyde content were significantly reversed by the MLE and OLE pretreatment. Besides, MLE and OLE pretreatment significantly protected the hepatic tissue against PTL-induced DNA damage, pathological perturbations, and increased caspase 3 and CYP2E1 immunoexpression. Of note, OLTG showed better enhancement of most indices rather than MLTG. Conclusively, these findings imply that OLE, with its antioxidant and antiapoptotic capabilities, is superior to MLE in protecting against PTL-induced liver injury.

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“…These ROS can cause oxidative damage to cellular macromolecules such as lipids, proteins, and DNA, leading to cellular dysfunction and damage [40,41]. PHZ-induced oxidative stress can also lead to the depletion of endogenous antioxidant enzymes which are involved in scavenging ROS [42,43].…”

Section: Discussionmentioning

confidence: 99%

“…PHZ triggers the production of excessive ROS, disrupting the balance between oxidation and antioxidant defence. This imbalance results in lipid peroxidation (LPO) and eventual oxidative harm to proteins and DNA [42,43]. MDA is the main result of the peroxidation of polyunsaturated fatty acids, and its presence indicates the level of injury in cells or tissues.…”

Section: Effect On Oxidative Stress Parametersmentioning

confidence: 99%

Honey Attenuates Phenylhydrazine-Induced Hematotoxicity and Oxidative Stress in Male Wistar Rats

Chinko

Pughikumo

Obia

et al. 2023

IBRR

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Honey is a sweet, viscous food substance produced by bees using nectar from flowers. Due to its complex chemical composition, it has been widely used in traditional medicine for its therapeutic properties. The present study evaluated the protective role of honey in attenuating phenylhydrazine (PHZ)-induced toxicity in male Wistar rats. Twenty (20) male Wistar rats with a weight range of 200-250g were used for the study. They were allocated into four (4) groups consisting of five (5) rats each. In the first phase of the experiment, animals in group I (control) received distilled water while animals in groups II, III and IV received 2ml of 15, 30 and 60% honey respectively by oral gavage. In the second phase, haematotoxicity and oxidative stress were induced by intraperitoneal injection of phenylhydrazine (PHZ) at 50 mg/kg to all twenty (20) animals, daily for two (days). The animals continued to receive distilled water and honey as in phase one. Blood collected from animals was analyzed for haematological and oxidative stress parameters following standard laboratory procedures. Results from the present study show significantly increased packed cell volume, haemoglobin concentration, red blood cell, total white blood cell and neutrophil counts among the experimental groups compared to the control (p<0.05). Also, superoxide dismutase, catalase and glutathione levels increased among the honey-supplemented experimental groups compared while MDA levels reduced compared to the control (P<0.05). The study concludes that oral supplementation of honey may have protected against phenylhydrazine-induced toxicity evidenced by increased packed cell volume, red blood cell, white blood cell and neutrophile counts, catalase and superoxide dismutase as well reduced malondialdehyde. The present evidence suggests that honey could attenuate haematotoxicity and oxidative stress caused by phenylhydrazine.

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Insights into the ameliorative effect of oleic acid in rejuvenating phenylhydrazine induced oxidative stress mediated morpho-functionally dismantled erythrocytes

Abstract: Graphical abstract

Cited by 7 publications

References 91 publications

Evaluation of haematinic activity of <i>Tapinanthus globiferus</i> (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats

Evaluation of haematinic activity of <i>Tapinanthus globiferus</i> (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats

The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

Honey Attenuates Phenylhydrazine-Induced Hematotoxicity and Oxidative Stress in Male Wistar Rats

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