Insights into the antimicrobial properties of a cationic steroid and antibiofilm performance in PDMS-based coatings to potentially treat urinary infections

Neves, Ana Rita; Freitas-Silva, Joana; Durães, Fernando; Silva, Elisabete; Rodrigues, Inês C.; Mergulhão, Filipe; Gomes, Marisa; Santos, Rita S.; André, Maria Bernardes; Silva, Renata; Remião, Fernando; Pinto, Eugénia; Costa, Paulo Martins da; Sousa, Emı́lia; Correia-da-Silva, Marta

doi:10.1039/d3tb01185b

Cited by 1 publication

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References 67 publications

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“…Although ceragenins are cholic acid-based compounds, they mimic the physicochemical properties and mechanism of action of host defense peptides, particularly in terms of their membrane mechanism of action [ 17 ]. Currently, there are a number of reports demonstrating the therapeutic efficacy of this group of molecules against bacterial, fungal, and viral pathogens [ 18 , 19 , 20 ]. The investigation into the efficacy of ceragenins against oral cavity-occurring bacteria has also shown promising findings.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Czarnowski,

Słowińska,

Sawieljew

et al. 2024

Pharmaceuticals

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Ensuring proper dental hygiene is of paramount importance for individuals’ general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthwashes, which have gained widespread acceptance; nevertheless, their limitations encourage investigating novel options in this domain. Our study indicates that ceragenins (CSAs) being lipid analogs of host defense peptides, well-recognized for their wide-ranging antimicrobial properties, may be a potentially efficacious means to augment oral hygiene in hospitalized individuals. We demonstrate that ceragenins CSA-13, CSA-44, and CSA-131 as well as undescribed to date CSA-255 display potent antimicrobial activities against isolates of fungi, aerobic, and anaerobic bacteria from Candida, Streptococcus, Enterococcus, and Bacteroides species, which are well-recognized representatives of microbes found in the oral cavity. These effects were further confirmed against mono- and dual-species fungal and bacterial biofilms. While the ceragenins showed similar or slightly diminished efficacy compared to commercially available mouthwashes, they demonstrated a highly favorable toxicity profile toward host cells, that may translate into better maintenance of host mucosal membrane stability. This suggests that incorporating ceragenins into oral hygiene products could be a valuable strategy for reducing the risk of both oral cavity-localized and secondary systemic infections and for improving the overall health outcomes of individuals receiving medical treatment.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Czarnowski,

Słowińska,

Sawieljew

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Insights into the antimicrobial properties of a cationic steroid and antibiofilm performance in PDMS-based coatings to potentially treat urinary infections

Abstract: Currently, multidrug-resistant (MDR) infections are one of the most important threats, driving the search for new antimicrobials compounds. Cationic peptide antibiotics (CPAs) and ceragenins (CSAs) contain in their structures cationic...

Cited by 1 publication

References 67 publications

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

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