Insights into the apatite mineralization potential of thermally processed nanocrystalline Ca10−xFex(PO4)6(OH)2

Radha, G.; Venkatesan, Balaji; Padmanaban, Rajashree; Vellaichamy, Elangovan; Balakumar, S.

doi:10.1039/c8nj03579b

Cited by 12 publications

(10 citation statements)

References 67 publications

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“…The presence of MNPs increased the overall negative charge on the surface, thus, with increasing concentration of MNPs in the scaffolds, there is a stronger induction capability for apatite formation by attracting Ca 2+ , and MNPs act as nucleating sites for the cation and anion interaction to form apatite nuclei, thus accelerating biomineralization . These results are supported by similar findings by Radha et al wherein Fe-nHAp biomaterials with lower degrees of crystallinity and decomposition rates showed a higher ionic release in acellular biomineralization immersion solutions …”

Section: Resultssupporting

confidence: 80%

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Hydrogel Composite Magnetic Scaffolds: Toward Cell-Free In Situ Bone Tissue Engineering

Xue,

Gurav,

Elsharkawy

et al. 2023

ACS Appl. Bio Mater.

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Reconstruction of critical sized bone defects in the oral and maxillofacial region continues to be clinically challenging despite the significant development of osteo-regenerative materials. Among 3D biomaterials, hydrogels and hydrogel composites have been explored for bone regeneration, however, their inferior clinical performance in comparison to autografts is mainly attributed to variable rates of degradation and lack of vascularization. In this study, we report hydrogel composite magnetic scaffolds formed from calcium carbonate, poly(vinyl alcohol) (PVA), and magnetic nanoparticles (MNPs), using PVA as matrix and calcium carbonate particles in vaterite phase as filler, to enhance the cross-linking of matrix and porosity with MNPs that can target and regulate cell signaling pathways to control cell behavior and improve the osteogenic and angiogenic potential. The physical and mechanical properties were evaluated, and cytocompatibility was investigated by culturing human osteoblast-like cells onto the scaffolds. The vaterite phase due to its higher solubility in comparison to calcium phosphates, combined with the freezing−thawing process of PVA, yielded porous scaffolds that exhibited adequate thermal stability, favorable water-absorbing capacity, excellent mineralization ability, and cytocompatibility. An increasing concentration from 1, 3, and 6 wt % MNPs in the scaffolds showed a statistically significant increase in compressive strength and modulus of the dry specimens that exhibited brittle fracture. However, the hydrated specimens were compressible and showed a slight decrease in compressive strength with 6% MNPs, although this value was higher compared to that of the scaffolds with no MNPs.

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Section: Resultssupporting

confidence: 80%

“…Scaffolds for bone tissue engineering should enable biomineralization and integration with the surrounding bone . As shown in Figure , the scaffolds in the mineralization solution exhibited a gradual dissolution of spherical vaterite particles and the deposition of smaller cauliflower-like apatite crystals.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Composite Magnetic Scaffolds: Toward Cell-Free In Situ Bone Tissue Engineering

Xue,

Gurav,

Elsharkawy

et al. 2023

ACS Appl. Bio Mater.

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“…However, no jagged edges were observed on these crystal grains since the abundant Ca and P in the solution were helpful for the development of crystals with Ca and P. After immersion, FS-BCS showed small holes and much smaller grains, implying the degradation behavior during the immersion process. In addition, aggregated spherical precipitation with a high Ca/P ratio was observed in some places on the FS-BCS surface, stating that adding Sr was beneficial to keep the bioactivity . The dissolution of Ca and Sr was observed after immersion, whereas no Fe was observed in the fluid with the detection method that we used.…”

Section: Discussionmentioning

confidence: 86%

“…In addition, aggregated spherical precipitation with a high Ca/P ratio was observed in some places on the FS-BCS surface, stating that adding Sr was beneficial to keep the bioactivity. 47 The dissolution of Ca and Sr was observed after immersion, whereas no Fe was observed in the fluid with the detection method that we used. For one reason, as mentioned before, the bonds of Fe−O and Fe−P are both high, increasing the water resistance of materials but decreasing the bioactivity.…”

Section: Discussionmentioning

confidence: 98%

“…It is well known that the bioactivity of materials originates from the exchange of ions between materials and body fluids, forming nucleation sites, triggering Ca and P deposition for crystal growth, and finally forming hydroxyapatite, which has a similar composition to human bone tissue . For BCS, S-BCS, and FS-BCS, the Ca concentration increased in the solution after immersion and bioactivity was observed on the surface of these materials.…”

Section: Discussionmentioning

confidence: 99%

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Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Li,

Ma,

et al. 2023

ACS Biomater. Sci. Eng.

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There is an urgent demand for antibacterial bone grafts in clinics. Worryingly, the misuse and overuse of antibiotics accelerate the emergence of drug-resistant bacteria. Therefore, this study prepared a novel injectable bioceramic cement without antibiotics (FS-BCS), which showed good antibacterial properties by loading iron and strontium onto a matrix composed of brushite and calcium sulfate. The setting time, injectability, microstructure, antibacterial properties, anti-biofilm properties, and cytocompatibility of the novel bioceramic cement were evaluated thoroughly. The results showed that the material was highly injectable and antiwashout. The antibacterial tests revealed that FS-BCS inhibited the growth of 99.9% E. coli and S. aureus separately in the broth due to the synergistic effect of strontium and iron. Simultaneously, crystal violet and fluorescent staining tests revealed that the material could significantly inhibit the formation of E. coli and S. aureus biofilms. In addition, the co-incorporation of iron and strontium promoted the proliferation and migration of osteoblasts. Therefore, FS-BCS has good application potential in antibiotic-free anti-infection bone grafting using minimally invasive surgery.

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Hydroxyapatite‐based dental inserts: Microstructure, mechanical properties, bonding efficiency and fracture resistance of molars with occlusal restorations

Matic,

Zebic,

Miletic

et al. 2023

J Biomed Mater Res

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This study aimed to (1) comparatively analyze properties of Sr‐ and Mg‐substituted hydroxyapatite (HAP)‐based dental inserts; (2) evaluate insert bonding to restorative materials, and (3) evaluate the effect of doped HAP inserts on fracture resistance (FR) of human molars with large occlusal restorations. By ion‐doping with Sr or Mg, 3 insert types were obtained and characterized using XRD, SEM, Vickers hardness and fracture toughness. Shear bond strength (SBS) was determined between acid etched or unetched inserts and following materials: Maxcem cement (Kerr); Filtek Z250 (3M) bonded with Single Bond Universal (SBU; 3M) or Clearfil Universal (Cf; Kuraray). Modified Class I cavities were prepared in 16 intact molars and restored using insert + composite or composite only (control) (n = 8/group). FR of restored molars was determined by static load until fracture upon thermal cycling. Fracture toughness was similar between Sr/Mg‐doped inserts (0.94–1.04 MPam−1/2 p = .429). Mg‐doped inserts showed greater hardness (range 4.78–5.15 GPa) than Sr6 inserts (3.74 ± 0.31 GPa; p < .05). SBS for SBU and Cf adhesives (range 7.19–15.93 MPa) was higher than for Maxcem (range 3.07–5.95 MPa) (p < .05). There was no significant difference in FR between molars restored with insert‐containing and control restorations (3.00 ± 0.30 kN and 3.22 ± 0.42 kN, respectively; p > .05). HAP‐based inserts doped with Mg/Sr had different composition and mechanical properties. Adhesive bonding to inserts resulted in greater bond strength than cementation, which may be improved by insert acid‐etching. Ion‐doped HAP inserts did not affect FR of restored molars. In conclusion, HAP‐based dental inserts may potentially replace dentin in large cavities, without affecting fracture resistance of restored teeth.

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Insights into the apatite mineralization potential of thermally processed nanocrystalline Ca_10−xFe_x(PO₄)₆(OH)₂

Abstract: The thermal treatment of Ca10−xFex(PO4)6(OH)2 at different temperatures had an effect on the mineralization potential under non-cellular and cellular conditions by releasing its bioactive ions at optimal or excessive levels.

Cited by 12 publications

References 67 publications

Hydrogel Composite Magnetic Scaffolds: Toward Cell-Free In Situ Bone Tissue Engineering

Hydrogel Composite Magnetic Scaffolds: Toward Cell-Free In Situ Bone Tissue Engineering

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery

Hydroxyapatite‐based dental inserts: Microstructure, mechanical properties, bonding efficiency and fracture resistance of molars with occlusal restorations

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