Insights into the applications and prospects of ionic liquids towards the chemistry of biomolecules

Richu,; Sharmhal, Asha; Kumar, Ashish; Kumar, Ashwani

doi:10.1016/j.molliq.2022.120580

Cited by 6 publications

(3 citation statements)

References 252 publications

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“…In contrast, the majority of the studies on the impact of ILs on various proteins concern possible IL applications in biotechnology and thus address the interactions between a particular IL and a particular protein from the viewpoint of stabilizing/destabilizing effects of the former on the latter. ,,− Thus, sometimes it is difficult to discern possible biotechnological advantages or disadvantages of ILs from their deleterious impact on proteins. Therefore, in the corresponding section of the review, we discuss only the most evident cases of inhibitory effects of ILs on proteins, which include the enzymes acetylcholinesterase, citrate synthase, adenosine deaminase, carboxylesterase, and cytochrome c oxidase, as well as the transporter proteins MATE1 and MATE2-K.…”

Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 99%

“…Starting from molten salt electrolytes in the 1960s, we have reached the land of (almost) infinite possibilities where any property or application you can think of is possible, at least, theoretically . For example, ILs have been successfully applied in organic synthesis (both as reaction media and catalysts), − electrochemistry, − biomass conversion and biotechnology, − extraction and separation, − and many other fields. ,− …”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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Section: Mechanisms Of Biological Activity Of Ionic Liquids: State Of...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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show abstract

“…There are plenty of reviews concerning the physicochemical properties of ILs in the literature. − Besides, there are many studies on these properties of ILs. − …”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of Temperature on the Physicochemical Properties of NMP-PA Ionic Liquid

Albayrak

2024

J. Chem. Eng. Data

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Ionic liquids (ILs), on which much research has been done over the past two decades, have the potential to be used in organic reactions, Li-ion batteries, metal electroplating, extraction and separation processes, gas chromatography columns, carbon capture, desulfurization, and pharmaceutical industries. However, it is important to know ILs' physicochemical properties in order to evaluate the effects of them on the process and their use in the above-mentioned areas. N-Methyl pyrrolidone (NMP) and o-phosphoric acid (PA) have antimicrobial properties. NMP-PA IL synthesized from these two compounds may also have synergistic antimicrobial properties. In this study, FTIR, 1 H NMR, 31 P NMR, and DSC analysis were performed for the characterization of the synthesized NMP-PA IL. In addition, the density, refractive index, and dynamic viscosity of the synthesized IL were determined at different temperatures. The experimental data were correlated to empirical models. From the measurement results, it was found that the NMP-PA IL has a viscosity higher than that of the imidazolium-based ILs. Density and refractive index values of the IL were shown to be comparable to those of imidazolium-based ILs.

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Sustainable recovery and recycling of acidic ionic liquid in 5-ethoxymethylfurfural production via bipolar membrane electrodialysis

Liang,

Fan,

Zhang

et al. 2024

Journal of Molecular Liquids

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Insights into the applications and prospects of ionic liquids towards the chemistry of biomolecules

Cited by 6 publications

References 252 publications

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Investigation of the Effect of Temperature on the Physicochemical Properties of NMP-PA Ionic Liquid

Sustainable recovery and recycling of acidic ionic liquid in 5-ethoxymethylfurfural production via bipolar membrane electrodialysis

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