Insights into the Evolution of Spermatogenesis-Related Ubiquitin–Proteasome System Genes in Abdominal Testicular Laurasiatherians

Ding, Xiaoyue; Cao, Li; Zheng, Yu; Zhou, Xu; He, Xiaofang; Xu, Shixia

doi:10.3390/genes12111780

Cited by 1 publication

(1 citation statement)

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“…An adequate temperature is crucial in maintaining normal spermatogenesis in the testes. The scrotal temperature is 2-4 • C lower than the normal core body temperature [82,83]. Any factor that increases the scrotal temperature will negatively affect the process of spermatogenesis [84].…”

Section: Environmental Factors and Male Fertility: State-of-the-art K...mentioning

confidence: 98%

Environmental and Genetic Traffic in the Journey from Sperm to Offspring

Sengupta,

Dutta,

Liew

et al. 2023

Biomolecules

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Recent advancements in the understanding of how sperm develop into offspring have shown complex interactions between environmental influences and genetic factors. The past decade, marked by a research surge, has not only highlighted the profound impact of paternal contributions on fertility and reproductive outcomes but also revolutionized our comprehension by unveiling how parental factors sculpt traits in successive generations through mechanisms that extend beyond traditional inheritance patterns. Studies have shown that offspring are more susceptible to environmental factors, especially during critical phases of growth. While these factors are broadly detrimental to health, their effects are especially acute during these periods. Moving beyond the immutable nature of the genome, the epigenetic profile of cells emerges as a dynamic architecture. This flexibility renders it susceptible to environmental disruptions. The primary objective of this review is to shed light on the diverse processes through which environmental agents affect male reproductive capacity. Additionally, it explores the consequences of paternal environmental interactions, demonstrating how interactions can reverberate in the offspring. It encompasses direct genetic changes as well as a broad spectrum of epigenetic adaptations. By consolidating current empirically supported research, it offers an exhaustive perspective on the interwoven trajectories of the environment, genetics, and epigenetics in the elaborate transition from sperm to offspring.

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Section: Environmental Factors and Male Fertility: State-of-the-art K...mentioning

confidence: 98%