Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish

Perdiguero, Pedro; Goméz-Esparza, Maria C; Martin, Diana L.; Bird, Steve; Soleto, Irene; Morel, Esther; Díaz‐Rosales, Patricia; Tafalla, Carolina

doi:10.3389/fimmu.2020.596975

Cited by 14 publications

(19 citation statements)

References 56 publications

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“…This result is like previous report (Zhao et al 2014). Prdm1b as a closely relative of Hobit (Perdiguero et al 2020) was also detected in all tissues and all stages of the embryos. The expression of Prdm1 homologs in the immune organs of medaka is like the nding in rainbow trout (Perdiguero et al 2020).…”

Section: Repression Of Bcl6aa By Prdm1mentioning

confidence: 83%

“…A mutation of possible Bcl6 binding site in the 5′-regulation region of prdm1 gene of Japanese ounder increased the reporter activity in vitro (Li et al 2017). The possible binding sites were also found in rainbow trout prdm1 genes (Perdiguero et al 2020). However, whether Prdm1 and Bcl6 repress each other in the same way as that in mammals is not reported.…”

Section: Introductionmentioning

confidence: 88%

“…Prdm1a and Prdm1b are closely related to mammalian Prdm1 and Hobit respectively. Prdm1c is evolved from duplication of Prdm1a in sh (Perdiguero et al 2020). Prdm1a has been reported in fugu (Ohtani and Miyadai 2011;Ohtani et al 2006a), zebra sh (Ingham and Kim 2005;Page et al 2013;Roy and Ng.…”

Section: Introductionmentioning

confidence: 99%

“…Prdm1a has been reported in fugu (Ohtani and Miyadai 2011;Ohtani et al 2006a), zebra sh (Ingham and Kim 2005;Page et al 2013;Roy and Ng. 2004;Wilm and Solnica-Krezel 2005), rainbow trout (Diaz-Rosales et al 2009;Perdiguero et al 2020;Zwollo 2011), medaka (Zhao et al 2014), Nile tilapia (Wu et al 2019), and Japanese ounder (Liu et al 2016). Prdm1a plays important roles in embryonic development such as n, muscle, and cloaca, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Rainbow trout prdm1a could be upregulated by IL-2 (Diaz-Rosales et al 2009). Rainbow trout prdm1a, prdm1b, and prdm1c transcripts were identi ed in the B and T cells and were upregulated in the head kidney and spleen after infection of Viral hemorrhagic septicemia virus (VHSV) (Perdiguero et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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Alternative splicing of medaka bcl6aa and its repression by Prdm1a and Prdm1b

Zhang

Yao

et al. 2021

Fish Physiol Biochem

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Bcl6 and Prdm1 (Blimp1) are a pair of transcriptional factors that repressing each other in the mammals.Prdm1 represses the expression of bcl6 by binding a cis-element of bcl6 gene in mammals. The homologs of Bcl6 and Prdm1 have been identi ed in teleost sh. However, whether these two factors regulate each other by the same way in sh as that in the mammals is not clear. In this study, the regulation of bcl6aa by Prdm1 was investigated in medaka. The mRNA of bcl6aa has three variants (bcl6aaX1-X3) at the 5′-end by alternative splicing with different promoters detected by RT-PCR. The three variants can be detected in adult tissues and developing embryos of medaka. The predicted proteins of Bcl6aaX1-X3 may have modi cation such as acetylation, C-mannosylation, phosphorylation, and sumoylation in the N-terminuses with different half-lives and relative translation e ciencies. Prdm1a and prdm1b are expressed in the tissues and embryos where and when bcl6aa is expressed. The expression of prdm1a was high while the expression of bcl6aa was low, and vice versa, detected in the spleen after stimulation with LPS or polyI:C. In vitro reporter assay indicated that bcl6aa could be directly repressed by both Prdm1a and Prdm1b in a dosage-dependent manner. After mutation of the key base, G, of all predicted binding sites in the core promoter region of bcl6aa, the repression by Prdm1a and/or Prdm1b disappeared. The consensus binding site of Prdm1 in bcl6aa gene is GAAAA(T/G). These results indicate that both Prdm1a and Prdm1b directly repress the expression of bcl6aa by binding the consensus binding site where the 5′-G is critical in medaka sh.

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Section: Repression Of Bcl6aa By Prdm1mentioning

confidence: 83%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alternative splicing of medaka bcl6aa and its repression by Prdm1a and Prdm1b

Zhang

Yao

et al. 2021

Fish Physiol Biochem

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Autophagy‐related genes polymorphism in hepatitis B virus‐associated hepatocellular carcinoma: A systematic review

Yousefi,

Tabibzadeh,

Jawaziri

et al. 2024

Immunity Inflam & Disease

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BackgroundChronic hepatitis B (CHB) virus is the most common risk factor for developing liver malignancy. Autophagy is an essential element in human cell maintenance. Several studies have demonstrated that autophagy plays a vital role in liver cancer at different stages. In this systematic review, we intend to investigate the role of polymorphism and mutations of autophagy‐related genes (ATGs) in the pathogenesis and carcinogenesis of the hepatitis B virus (HBV).Materials and MethodsThe search was conducted in online databases (Web of Science, PubMed, and Scopus) using Viruses, Infections, Polymorphism, Autophagy, and ATG. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses criteria.ResultsThe primary search results led to 422 studies. By screening and eligibility evaluation, only four studies were relevant. The most important polymorphisms in hepatocellular carcinoma were rs2241880 in ATG16L1, rs77859116, rs510432, and rs548234 in ATG5. Furthermore, some polymorphisms are associated with an increased risk of HBV infection including, rs2241880 in ATG16L1 and rs6568431 in ATG5.ConclusionThe current study highlights the importance of rs2241880 in ATG16L1 and rs77859116, rs510432, and rs548234 in ATG5 for HBV‐induced HCC. Additionally, some mutations in ATG16L1 and ATG5 were important in risk of HBV infection. The study highlights the gap of knowledge in the field of ATG polymorphisms in HBV infection and HBV‐induced HCC.

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The role of PRDM1 gene polymorphism in the progression of hepatocellular carcinoma in Egyptian patients

Mohamed

Esmail

Ibrahim

et al. 2022

Journal of Medical Virology

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In Egypt, hepatocellular carcinoma (HCC) ranks as the second largest cause of cancer mortality. PRDM1 is a tumor suppressor gene essential for the differentiation and regulation activity of plasma cells and T cells. It plays a vital role in T cell exhaustion of chronic viral infection and HCC. We aimed to study the role of PRDM1 gene polymorphism in HCV and HCC‐related to hepatitis C virus (HCV) progress in Egyptians. The case‐control study included 300 Egyptian patients divided into 100 HCC,100 cirrhosis, and 100 control. Laboratory investigations were done for some clinicopathological biomarkers, including liver function tests, complete blood picture, serum alpha‐fetoprotein, and hepatitis markers (HBsAg, anti‐HCV‐Ab). TaqMan allelic discrimination assay technique was used to genotype PRDM1 gene polymorphism. Multivariant analysis (logistic regression) assessed the association between the polymorphisms with HCC progression and designed the suggested model for HCC prediction. The frequencies of the G allele and GG phenotype in the control group were significantly more than that of the HCC and cirrhosis group. However, GA genotypes and A allele frequencies significantly increased in the HCC patients than in cirrhosis and controls. In addition, by comparing the HCC group and the non‐HCC group (controls and cirrhotic patients), the subjects carrying AA or GA have 2 times more risk to develop HCC than those carrying GG genotypes (odd ratio = 2.045% and 95% confidence interval are (1.123−3.722) p = 0.019). Multivariate analysis results suggested a model of Aspartate transaminase (AST), Albumin, and PRDM1 polymorphism to predict the risk of HCC in Egyptians. In addition, PRDM1 polymorphism has an association with HCC prognosis (tumor size). For PRDM1 polymorphism, the A allele and AA might be considered as HCC‐related to the HCV risk factor. In addition, AST, Albumin, and PRDM1 polymorphism predict the risk of HCC in Egyptians Therefore, the polymorphism might help in identifying the susceptible Egyptians to HCC. In addition, polymorphism might have a role in HCC prognosis.

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Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish

Cited by 14 publications

References 56 publications

Alternative splicing of medaka bcl6aa and its repression by Prdm1a and Prdm1b

Alternative splicing of medaka bcl6aa and its repression by Prdm1a and Prdm1b

Autophagy‐related genes polymorphism in hepatitis B virus‐associated hepatocellular carcinoma: A systematic review

The role of PRDM1 gene polymorphism in the progression of hepatocellular carcinoma in Egyptian patients

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