Insights into the impact of hepatitis B virus on hepatic stellate cell activation

You, Hua; Wang, Xing; Ma, Lihong; Zhang, Fulong; Zhang, Huanyang; Wang, Yuxin; Pan, Xiucheng; Zheng, Kuiyang; Kong, Fanyun; Tang, Renxian

doi:10.1186/s12964-023-01091-7

Cited by 10 publications

(3 citation statements)

References 105 publications

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“…However, HSC proliferation, contractility, and chemotaxis increase with the expression of HSC activation-related proteins such as smooth muscle actin (α-SMA) and abundant ECM proteins such as fibronectin and collagens. Liver damage induced by high-cholesterol diet consumption ( Teratani et al, 2012 ), virus infection ( Wang et al, 2016 ; You et al, 2023 ), or immune-mediated injury ( Xu et al, 2012 ) can transform qHSCs into aHSCs.…”

Section: Npcs: Hscsmentioning

confidence: 99%

Cellular heterogeneity and plasticity during NAFLD progression

Park

Choi

Kim

et al. 2023

Front. Mol. Biosci.

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Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression.

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Section: Npcs: Hscsmentioning

confidence: 99%

Cellular heterogeneity and plasticity during NAFLD progression

Park

Choi

Kim

et al. 2023

Front. Mol. Biosci.

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“…Despite the clear role of NKT1 cells and IFN-γ in HBV viral infection, it has been reported that HBV also promotes IL-4 and IL-13 production by iNKT cells, leading to the activation of hepatic stellate cells (HSCs), which are associated with the progression of liver fibrosis. Although the NKT subset has not been specifically defined, this profile could suggest the participation of the NKT2 cell subset [174,175]. On the other hand, liver NK1.1 − iNKT cells have been reported to produce IL-17, although their role is associated mainly with airway immunity, which will be addressed later [176].…”

Section: Role and Inkt Modulation Strategies In Infectious Diseases A...mentioning

confidence: 99%

Natural Killer T Cell Diversity and Immunotherapy

Tognarelli,

Gutiérrez-Vera,

Palacios

et al. 2023

Cancers

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Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein. This interaction produces the secretion of a wide array of cytokines by these cells, including interferon gamma (IFN-γ) and interleukin 4 (IL-4), allowing iNKTs to link innate with adaptive responses. Interestingly, molecules that bind CD1d have been identified that enable the modulation of these cells, highlighting their potential pro-inflammatory and immunosuppressive capacities, as required in different clinical settings. In this review, we summarize key features of iNKTs and current understandings of modulatory α-galactosylceramide (α-GalCer) variants, a model iNKT cell activator that can shift the outcome of adaptive immune responses. Furthermore, we discuss advances in the development of strategies that modulate these cells to target pathologies that are considerable healthcare burdens. Finally, we recapitulate findings supporting a role for iNKTs in infectious diseases and tumor immunotherapy.

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“…If it is not promptly prevented and treated, continued progression of liver fibrosis can eventually lead to cirrhosis and even hepatocellular carcinoma. Some research attributes this to the removal or elimination of chronic liver injury resulting from various factors ( Huang et al, 2023 ; Pellicano et al, 2023 ; You et al, 2023 ; Zhang et al, 2023 ) (suppression of extracellular matrix accumulation, anti-inflammatory, and anti-oxidative stress). However, no approved therapy for LF was used in clinical trials, which is in contrast with the robust effects of many anti-LF candidate drugs exhibited in experimental animal models.…”

Section: Introductionmentioning

confidence: 99%

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

Zhao,

Dai,

Dong

et al. 2023

Front. Mol. Biosci.

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Background: Liver fibrosis represents an intermediate stage in the progression of liver disease, and as of now, there exists no established clinical therapy for effective antifibrotic treatment.Purpose: Our aim is to explore the impact of Carbon dots derived from Vaccaria Semen Carbonisata (VSC-CDs) on carbon tetrachloride-induced liver fibrosis in mice.Methods: VSC-CDs were synthesized employing a modified pyrolysis process. Comprehensive characterization was performed utilizing various techniques, including transmission electron microscopy (TEM), multiple spectroscopies, X-ray photoelectron spectroscopy (XPS), and high-performance liquid chromatography (HPLC). A hepatic fibrosis model induced by carbon tetrachloride was utilized to evaluate the anti-hepatic fibrosis effects of VSC-CDs.Results: VSC-CDs, exhibiting a quantum yield (QY) of approximately 2.08%, were nearly spherical with diameters ranging from 1.0 to 5.5 nm. The VSC-CDs prepared in this study featured a negative charge and abundant chemical functional groups. Furthermore, these particles demonstrated outstanding dispersibility in the aqueous phase and high biocompatibility. Moreover, VSC-CDs not only enhanced liver function and alleviated liver damage in pathomorphology but also mitigated the extent of liver fibrosis. Additionally, this study marks the inaugural demonstration of the pronounced activity of VSC-CDs in inhibiting inflammatory reactions, reducing oxidative damage, and modulating the TGF-β/Smad signaling pathway.Conclusion: VSC-CDs exerted significant potential for application in nanodrugs aimed at treating liver fibrosis.

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Insights into the impact of hepatitis B virus on hepatic stellate cell activation

Cited by 10 publications

References 105 publications

Cellular heterogeneity and plasticity during NAFLD progression

Cellular heterogeneity and plasticity during NAFLD progression

Natural Killer T Cell Diversity and Immunotherapy

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

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