Insights into the invasive diagnostic challenges of coronary artery vasospasm – A systematic review

Rehan, Rajan; Beltrame, John F.; Yong, A.

doi:10.1016/j.jjcc.2023.07.020

Cited by 3 publications

(3 citation statements)

References 75 publications

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“…This pathology, already described in the 1950s by Prinzmetal et al, is considered fundamental for causing fatal pathogenetic mechanisms underlying SCD, such as acute coronary syndrome and ischemic myocardial disease. The mechanisms that lead to SCD from coronary atherosclerosis include transient spasm with coronary stenosis and hypoflow of blood to the heart [ 29 , 30 , 31 , 32 ]. In a recent work, Lin et al studied the mechanisms of coronary artery spasm in rabbit models by evaluating SELENBP1 and VCL as candidate biomarkers.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Sacco,

Gualtieri,

Calanna

et al. 2023

IJMS

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Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic purposes, as well as for judicial and preventive purposes for family members. Despite the completion of all routine post-mortem investigations, it is often complicated for the forensic pathologist to define the triggering cause of these events. The study of the proteome is proving to be extremely promising in the field of human cardiovascular disease. This paper aims to offer a literature review on the study of the proteome in post-mortem cadaveric biological samples obtained from SCD cases. The aim of this work is to outline the state of the art of the scientific advances that protein analysis can offer in the diagnosis of SCD and the limits that various studies have traced up to now. In conclusion, the work defines the future perspectives of this field in SCD, suggesting strategies to overcome the reported limits and improve the diagnostics of these events.

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Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Sacco,

Gualtieri,

Calanna

et al. 2023

IJMS

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“…Whilst acknowledging the importance of our findings, a notable limitation is the use of a fast ACh administration time of 20 s, which inherently predisposes to a higher likelihood of backup pacing. Nevertheless, this practice mirrors protocols employed by the Japanese Circulation Society (JCS) [1] , the CorMICA study [2] , and the Robert-Bosch-Krankenhaus institution [9] .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of temporary pacemaker during acetylcholine provocation testing

Rehan,

Wong,

Weaver

et al. 2024

IJC Heart & Vasculature

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“…Angina like chest pain, ECG changes during exercise, normal angiogram are also known as syndrome X (CSX). CSX is pathophysiologically linked to MVD which is the result of anatomic and functional abnormalities of coronary microcirculation [8].…”

Section: Introductionmentioning

confidence: 99%

Coronary vasospasm testing: escape from the cath lab!

Djordjevic Dikic,

Dedic,

Boskovic

et al. 2024

Explor Cardiol

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Coronary vasospasm stands as a widely acknowledged and frequent culprit behind chest pain, acute coronary syndrome, and sudden cardiac death, yet it remains a challenging diagnosis. Current guidelines recommend invasive coronary function testing to assess pathophysiology and mechanisms and to define treatment. In reality, this protocol is rarely applied, because it necessitates extended occupation of the cath lab, repetitive administration of nephrotoxic iodine contrast agents, the need for repeated testing on both coronary arteries leading to considerable radiation exposure, and significant direct expenses. The promising perspective for vasospasm testing is a noninvasive approach with advanced echocardiographic techniques, such as transthoracic Doppler echocardiography, with more sensitive indicators of ischemia. Hyperventilation and exercise tests are used for vasospasm directed testing, with assessment of the new parameters: coronary flow velocities and reserve, allowing to see deeper into macro and microvascular pathophysiology. Association between coronary flow, global longitudinal strain and microvascular dysfunction (MVD) and impaired values at hyperemia was previously demonstrated. Reduction in coronary flow velocity (CFV) despite heightened myocardial oxygen consumption and double product during hyperventilation are indicative of coronary vasospasm. Normal coronary angiography finding in patients with documented evidence of ischemia should initiate additional diagnostic testing in order to increase the yield of specific diagnosis in patients with suspected vasospasm, which could help to personalize treatment and prognosis. In order to achieve this, non-invasive provocative stress echocardiography tests should be included in the diagnostic workup. This approach, characterized by its simplicity, feasibility, safety, and efficacy, is currently undergoing extensive testing on a large scale.

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Insights into the invasive diagnostic challenges of coronary artery vasospasm – A systematic review

Cited by 3 publications

References 75 publications

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Usefulness of temporary pacemaker during acetylcholine provocation testing

Coronary vasospasm testing: escape from the cath lab!

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