Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo[1,5-a]pyrimidine scaffold

Abstract

Pyrazolopyrimidine core is the basic skeleton of many drugs with privileged biological profiles. In this study, the biological characteristics, and samples of synthetic approaches and reactivity of pyrazolo[1,5-a]pyrimidines were highlighted.

Synthesis, photophysical properties, anticancer evaluation, and molecular docking studies of new pyrimidine linked 4‐arylidene‐thiazolidin‐4‐ones as potent anticancer agents

“…Analogues based on pyrimidine and its annulated heterocyclic compounds have garnered significant interest due to their diverse biological properties, including antimicrobial [1][2][3], anti-inflammatory [4,5], antioxidant [6,7], antiviral [8], and antitumour [9][10][11][12] effectiveness.…”

“…Analogues based on pyrimidine and its annulated heterocyclic compounds have garnered significant interest due to their diverse biological properties, including antimicrobial [1–3], anti‐inflammatory [4, 5], antioxidant [6, 7], antiviral [8], and antitumour [9–12] effectiveness. Pyrimidines were prominent early in the history of organic chemistry as ‘ m ‐diazines’ arising from uric acid catabolism [13].…”

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

“…The objective of the present review is to highlight the diverse nano-catalysts applied to prepare heterocycles integrated pyridopyrimidine core. Through our preceding work regarding the signicance of reactive synthons in the synthesis of many heterocycles, 58,59 and many reviews that deliberated the chemistry fused pyrimidines, [60][61][62][63][64][65][66][67] and pyridopyrimidines, [68][69][70] we herein highlight the advancements in the synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported in nano-catalysis. The theme of the research is apprehensive with reviewing the mechanisms of the diverse reactions, nanocatalyst preparation, the benet of the used nanocatalyst, the nanocatalyst's efficient role for improved product yields, and increased reaction rates.…”

Mechanochemistry Frees Thiourea Dioxide (TDO) from the ‘Veils’ of Solvent, Exposing All Its Reactivity

“…Heterocycles are ubiquitous in biologically active compounds, natural products, and common pharmaceuticals [1][2][3][4][5][6][7][8][9], representing a highly privileged structural motif. For example, common biocides [10], fungicides [11], antitumoral agents [12,13], and analgesics [14][15][16], to mention a few, contain a benzimidazole or benzothiazole moiety in their structure.…”