Insights into the metal retention role in the antibacterial behavior of montmorillonite and cellulose tissue-supported copper and silver nanoparticles

Noori, Farzaneh; Nerée, Armelle Tchoumi; Megoura, Meriem; Mateescu, Mircea Alexandru; Azzouz, Abdelkrim

doi:10.1039/d1ra02854e

Cited by 9 publications

(7 citation statements)

References 71 publications

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“…1 H-NMR (300 MHz, D 2 O): δ 7.49 (s, 8H), 4.91 (d, J = 1.2 Hz, 4H), 4.79 (s, 16H), 3.89 (dd, J = 10.5, 5.7 Hz, 48H), 3.78 (dd, J = 12.5, 6.9 Hz, 1H), 3.69 (dd, J = 12.4, 3.5 Hz, 1H), 3.58 (dd, J = 16.9, 7.6 Hz, 1H), 3.51-3.45 (m, 84H); 13 Metal-entrapment in glycodendrimer. The cation-loaded dendrimers were obtained by adding 15 mg of the glycodendrimer to 10 mL aqueous solutions of either 0.0005 mol/L Cu(OAc) 2 or 0.0005 mol/L AgNO 3 under vigorous stirring at room temperature for 2 h according to Noori et al with minor modifications [35]. Then, to the obtained cation-containing glycodendrimers (11-Cu 2+ or 11-Ag + ) were added 10 mL of 0.001 mol/L NaBH 4 solution and the mixtures were stirred for 6 h at room temperature to afford zero-valent CuNP-loaded glycodendrimer (11-Cu 0 ) and AgNP-loaded glycodendrimer (11-Ag 0 ).…”

Section: Synthesis Of Peracetylated Glycodendrimer (10)mentioning

confidence: 99%

“…Other biopolymers, suitable as carriers for silver and copper are already used in the laboratory to control Gram-negative bacterial proliferation. It was previously shown [35,36] that zero-valent silver and copper hosted by carboxymethyl derivatives are bactericides against non-pathogenic Gram-negative bacteria. We propose now an investigation of the bactericidal activity of glycodendrimers unloaded and loaded zero-valent metals.…”

Section: Introductionmentioning

confidence: 99%

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Metallo-Glycodendrimeric Materials against Enterotoxigenic Escherichia coli

El Riz,

Tchoumi Neree,

Mousavifar

et al. 2024

Microorganisms

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Conjugation of carbohydrates to nanomaterials has been extensively studied and recognized as an alternative in the biomedical field. Dendrimers synthesized with mannose at the end group and with entrapped zero-valent copper/silver could be a potential candidate against bacterial proliferation. This study is aimed at investigating the bactericidal activity of metal-glycodendrimers. The Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction was used to synthesize a new mannosylated dendrimer containing 12 mannopyranoside residues in the periphery. The enterotoxigenic Escherichia coli fimbriae 4 (ETEC:F4) viability, measured at 600 nm, showed the half-inhibitory concentration (IC50) of metal-free glycodendrimers (D), copper-loaded glycodendrimers (D:Cu) and silver-loaded glycodendrimers (D:Ag) closed to 4.5 × 101, 3.5 × 101 and to 1.0 × 10−2 µg/mL, respectively, and minimum inhibitory concentration (MIC) of D, D:Cu and D:Ag of 2.0, 1.5 and 1.0 × 10−4 µg/mL, respectively. The release of bacteria contents onto broth and the inhibition of ETEC:F4 biofilm formation increased with the number of metallo-glycodendrimer materials, with a special interest in silver-containing nanomaterial, which had the highest activity, suggesting that glycodendrimer-based materials interfered with bacteria-bacteria or bacteria–polystyrene interactions, with bacteria metabolism and can disrupt bacteria cell walls. Our findings identify metal–mannose-dendrimers as potent bactericidal agents and emphasize the effect of entrapped zero-valent metal against ETEC:F4.

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Section: Synthesis Of Peracetylated Glycodendrimer (10)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metallo-Glycodendrimeric Materials against Enterotoxigenic Escherichia coli

El Riz,

Tchoumi Neree,

Mousavifar

et al. 2024

Microorganisms

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“…On account of that, metal ions are adsorbed on the cell wall by electrostatic attraction, causing shrinkage of the cytoplasm membrane or detachment of the cell wall, resulting in inactivation and inhibition in cell processes [17,41]. In this scenario, strong metal retention capacity of the solid support improves antimicrobial activity, which could be achieved by tailoring weak hydroxyl groups of polymer-metal interaction, and an optimum amount of metal-loaded polymer onto MMT substrate [42]. The adsorption of bacteria (Coliphages T1 and T7 of E. coli) on MMT clay was investigated for the first time by Schiffenbauer M. and Stotzky G. [43].…”

Section: Introductionmentioning

confidence: 99%

A Review on Montmorillonite-Based Nanoantimicrobials: State of the Art

et al. 2023

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One of the crucial challenges of our time is to effectively use metal and metal oxide nanoparticles (NPs) as an alternative way to combat drug-resistant infections. Metal and metal oxide NPs such as Ag, Ag2O, Cu, Cu2O, CuO, and ZnO have found their way against antimicrobial resistance. However, they also suffer from several limitations ranging from toxicity issues to resistance mechanisms by complex structures of bacterial communities, so-called biofilms. In this regard, scientists are urgently looking for convenient approaches to develop heterostructure synergistic nanocomposites which could overcome toxicity issues, enhance antimicrobial activity, improve thermal and mechanical stability, and increase shelf life. These nanocomposites provide a controlled release of bioactive substances into the surrounding medium, are cost effective, reproducible, and scalable for real life applications such as food additives, nanoantimicrobial coating in food technology, food preservation, optical limiters, the bio medical field, and wastewater treatment application. Naturally abundant and non-toxic Montmorillonite (MMT) is a novel support to accommodate NPs, due to its negative surface charge and control release of NPs and ions. At the time of this review, around 250 articles have been published focusing on the incorporation of Ag-, Cu-, and ZnO-based NPs into MMT support and thus furthering their introduction into polymer matrix composites dominantly used for antimicrobial application. Therefore, it is highly relevant to report a comprehensive review of Ag-, Cu-, and ZnO-modified MMT. This review provides a comprehensive overview of MMT-based nanoantimicrobials, particularly dealing with preparation methods, materials characterization, and mechanisms of action, antimicrobial activity on different bacterial strains, real life applications, and environmental and toxicity issues.

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“…Recently, an innovative approach of integration of antibacterial nanoparticles into monolithic nanofiber scaffolds has been investigated due to its advantages of cost-effectiveness, quick response, and structural simplicity. Metal (Cu, Au), − metallic oxide (Fe 3 O 4 , glass particles), , or extracted bioparticles such as cellulose nanocrystal particles , incorporated into monolithic fiber scaffolds for controlled drug delivery has aroused great interest. For example, silver nanoparticles were incorporated into cotton fibers, which demonstrated great antibacterial activities. − Silica nanoparticles encapsulating fluorescein and rhodamine B were integrated into poly(lactic- co -glycolic acid) (PLGA) fibrous scaffolds, demonstrating controlled release of drugs. − Results from Xing’s study showed lysophosphatidic acid and zinc oxide nanoparticles were successfully incorporated into nanofibers .…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into Polyurethane/Poly(ethylene oxide) Nanofiber Scaffolds for Biomedical Applications

Sun,

Heacock,

Chen

et al. 2023

ACS Appl. Nano Mater.

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The development of wound-dressing materials has attracted significant research interests in recent years. With the advancement of nanofabrication, the application of nanoparticles (NPs) in drug delivery systems has become feasible. However, most existing work focuses on incorporation of metal, metal/semimetal oxide, or organic particles into nanofiber scaffolds. There has been a lack of work on the incorporation of drug-encapsulated polymeric particles into nanofiber scaffolds. In this study, gentamicin-encapsulated poly(lactic-co-glycolic acid) (PLGA) NPs were synthesized via a double emulsion solvent evaporation method. Electrospinning was used to incorporate gentamicinencapsulated PLGA NPs into nanofiber scaffolds. Atomic force microscopy (AFM), dynamic light scattering, scanning electron microscopy (SEM), ultraviolet−visible spectroscopy (UV−vis), and an agar diffusion method were utilized to characterize the morphologies, release profiles, and antibacterial activities of various gentamicin-loaded PLGA NP-incorporated nanofiber scaffolds. The results indicated that the PLGA NPs had a spherical morphology with an average diameter of 130 nm. Purification of PLGA NPs was essential to eliminate the residual poly(vinyl alcohol) (PVA) and to prevent particle agglomeration. The purified PLGA NPs were uniformly and individually incorporated into the polyurethane (PU)/ poly(ethenyl oxide) (PEO) or PEO-only nanofiber scaffolds but nearly none into the PU-only fiber scaffolds. PEO served as a continuous phase in the PU/PEO mixture, which significantly improved the compatibility of PLGA NPs and PU, resulting in a well-dispersed distribution of PLGA NPs in the monolithic nanofiber scaffolds. Excellent antibacterial properties against Escherichia coli were found in both PU/PEO and PEO nanofiber scaffolds. This study of incorporating gentamicin-encapsulated PLGA NPs into fiber scaffolds provides insights for achieving successful incorporation of drug-encapsulated polymeric NPs into fiber scaffolds. This offers a promising microfabrication technology for delivery of therapeutic molecules with controlled release for biomedical applications.

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Insights into the metal retention role in the antibacterial behavior of montmorillonite and cellulose tissue-supported copper and silver nanoparticles

Abstract: The role of the retention strength of Cu0 and Ag0 nanoparticles on the induced antibacterial properties of montmorillonite and cellulose-supported polyol dendrimer against Escherichia coli DH5α and Bacillus subtilis 168 was comparatively investigated.

Cited by 9 publications

References 71 publications

Metallo-Glycodendrimeric Materials against Enterotoxigenic Escherichia coli

Metallo-Glycodendrimeric Materials against Enterotoxigenic Escherichia coli

A Review on Montmorillonite-Based Nanoantimicrobials: State of the Art

Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into Polyurethane/Poly(ethylene oxide) Nanofiber Scaffolds for Biomedical Applications

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