Insights into the microbial degradation and biochemical mechanisms of carbamates

Mishra, Sandhya; Pang, Shimei; Zhang, Wenping; Lin, Ziqiu; Bhatt, Pankaj; Chen, Shaohua

doi:10.1016/j.chemosphere.2021.130500

Cited by 96 publications

(37 citation statements)

References 153 publications

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“…The main technique for solving pesticide pollutants is chemical degradation [ 43 ]. Other common solutions for solving pesticide pollutants include chlorination, hydrodynamic cavitation, active carbon, O 2 plasma, metal catalysts, and H 2 O 2 and O 3 adsorption [ 14 ].…”

Section: Physicochemical Transformation Of Ddvpmentioning

confidence: 99%

Emerging Technologies for Degradation of Dichlorvos: A Review

Zhang

et al. 2021

IJERPH

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Dichlorvos (O,O-dimethyl O-(2,2-dichlorovinyl)phosphate, DDVP) is a widely acknowledged broad-spectrum organophosphorus insecticide and acaracide. This pesticide has been used for more than four decades and is still in strong demand in many developing countries. Extensive application of DDVP in agriculture has caused severe hazardous impacts on living systems. The International Agency for Research on Cancer of the World Health Organization considered DDVP among the list of 2B carcinogens, which means a certain extent of cancer risk. Hence, removing DDVP from the environment has attracted worldwide attention. Many studies have tested the removal of DDVP using different kinds of physicochemical methods including gas phase surface discharge plasma, physical adsorption, hydrodynamic cavitation, and nanoparticles. Compared to physicochemical methods, microbial degradation is regarded as an environmentally friendly approach to solve several environmental issues caused by pesticides. Till now, several DDVP-degrading microbes have been isolated and reported, including but not limited to Cunninghamella, Fusarium, Talaromyces, Aspergillus, Penicillium, Ochrobium, Pseudomonas, Bacillus, and Trichoderma. Moreover, the possible degradation pathways of DDVP and the transformation of several metabolites have been fully explored. In addition, there are a few studies on DDVP-degrading enzymes and the corresponding genes in microorganisms. However, further research relevant to molecular biology and genetics are still needed to explore the bioremediation of DDVP. This review summarizes the latest development in DDVP degradation and provides reasonable and scientific advice for pesticide removal in contaminated environments.

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Section: Physicochemical Transformation Of Ddvpmentioning

confidence: 99%

Emerging Technologies for Degradation of Dichlorvos: A Review

Zhang

et al. 2021

IJERPH

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“…Their mode of actuation is similar to the organophosphate class that inhibits the acetylcholinesterase enzyme and provides the overstimulation of the nervous system (Ghosh et al, 2015;Verma et al, 2021). However, carbamates toxicity is lower compared to organophosphate, due to its shorter half-life and reversible effects; moreover, their degradation can be accelerated by microbial degradation oxidation and hydrolysis of the compounds (Bhatt et al, 2021;Mishra et al, 2020Mishra et al, , 2021. Thus, Table 1 presents all the 27 carbamates with their, respectively, chemical structure, which present a carbamic acid (R-O-CO-NH-R') (Bleecker, 2008;Gupta, 2006;Horsak et al, 2005;Pang et al, 2020).…”

Section: General Considerationsmentioning

confidence: 99%

“…In in-vitro studies had shown that carbamates and dithiocarbamates can provide adverse effects, such as alteration in the reproduction, genotoxicity, cytotoxicity, and among other effects in animals and human cells. Carbamates can cause the inhibition of succinic dehydrogenase activity in hamsters, and provide apoptosis and necrosis to some cells in humans (Bhatt et al, 2021;Adeyemi & Onwudiwe, 2020;Mishra et al, 2020Mishra et al, , 2021Riadi et al, 2010). Table 1 shows the toxic effects for each carbamate and dithiocarbamates, which are provided by ingestion of inadequate concentration of carbamates and/or dithiocarbamates, such as in the central nervous system and thyroid, neuropathology, bone tumors, uterus, bladder, adrenal gland, kidney, and liver, among others.…”

Section: Ta B L Ementioning

confidence: 99%

“…Table 1 shows the toxic effects for each carbamate and dithiocarbamates, which are provided by ingestion of inadequate concentration of carbamates and/or dithiocarbamates, such as in the central nervous system and thyroid, neuropathology, bone tumors, uterus, bladder, adrenal gland, kidney, and liver, among others. Hence, toxicity researches have established LD 50 to carbamates and dithiocarbamates that are between 2.50 and 200 mg kg -1 and 18 and 4000 mg kg -1 , respectively (Biscaldi et al, 1986;Cao et al, 2019;EPA, 1994bEPA, , 1994aEPA, , 1995EPA, , 1997EPA, , 1998EPA, , 2004bEPA, , 2004aEPA, , 2005aEPA, , 2005bEuropean Food Safety Authority, 2010;Food and Agriculture Organization of the United Nations & World Health Organization, 2020;Gupta, 2018;Gupta, 2006;Deshpande, 2002;Janz, 2014;McCarroll et al, 2002;Mishra et al, 2021;Padilla et al, 2007;Park et al, 2021;Rodgers, 2001;Sams et al, 2010;Shibamoto & Bjeldanes, 2004;European Union, 2020;Zhu et al, 2019).…”

Section: Ta B L Ementioning

confidence: 99%

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Current overview and perspectives in environmentally friendly microextractions of carbamates and dithiocarbamates

Martins

Batista

Melchert

2021

Comp Rev Food Sci Food Safe

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Carbamates and dithiocarbamates are two classes of pesticides widely employed in the agriculture practice to control and avoid pests and weeds, hence, the monitoring of the residue of those pesticides in different foodstuff samples is important. Thus, this review presents the classification, chemical structure, use, and toxicology of them. Moreover, it was shown the evolution of liquid-and solidphase microextractions employed in the extraction of carbamates and dithiocarbamates in water and foodstuff samples. The classification, operation mode, and application of the microextractions of liquid-phase and solid-phase used in their extraction were discussed and related to the analytical parameters and guidelines of green analytical chemistry.

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“…They show broad-spectrum activity against insects, nematodes, molluscs as well as arachnids. Furthermore, they function as herbicides by inhibiting the photosynthesis electron transport chain and fungicides by binding spindle microtubules and causing nuclear division blockade ( Singh et al, 2016 ; Pujar et al, 2019 ; Mishra et al, 2021b ). Examples of some of the commonly used carbamate pesticides include fenobucarb, carbofuran, phenmedipham, carbendazim, aldicarb, methomyl, oxamyl, propoxur and Carbaryl ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Conserved Metabolic and Evolutionary Themes in Microbial Degradation of Carbamate Pesticides

2021

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Carbamate pesticides are widely used as insecticides, nematicides, acaricides, herbicides and fungicides in the agriculture, food and public health sector. However, only a minor fraction of the applied quantity reaches the target organisms. The majority of it persists in the environment, impacting the non-target biota, leading to ecological disturbance. The toxicity of these compounds to biota is mediated through cholinergic and non-cholinergic routes, thereby making their clean-up cardinal. Microbes, specifically bacteria, have adapted to the presence of these compounds by evolving degradation pathways and thus play a major role in their removal from the biosphere. Over the past few decades, various genetic, metabolic and biochemical analyses exploring carbamate degradation in bacteria have revealed certain conserved themes in metabolic pathways like the enzymatic hydrolysis of the carbamate ester or amide linkage, funnelling of aryl carbamates into respective dihydroxy aromatic intermediates, C1 metabolism and nitrogen assimilation. Further, genomic and functional analyses have provided insights on mechanisms like horizontal gene transfer and enzyme promiscuity, which drive the evolution of degradation phenotype. Compartmentalisation of metabolic pathway enzymes serves as an additional strategy that further aids in optimising the degradation efficiency. This review highlights and discusses the conclusions drawn from various analyses over the past few decades; and provides a comprehensive view of the environmental fate, toxicity, metabolic routes, related genes and enzymes as well as evolutionary mechanisms associated with the degradation of widely employed carbamate pesticides. Additionally, various strategies like application of consortia for efficient degradation, metabolic engineering and adaptive laboratory evolution, which aid in improvising remediation efficiency and overcoming the challenges associated with in situ bioremediation are discussed.

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Insights into the microbial degradation and biochemical mechanisms of carbamates

Cited by 96 publications

References 153 publications

Emerging Technologies for Degradation of Dichlorvos: A Review

Emerging Technologies for Degradation of Dichlorvos: A Review

Current overview and perspectives in environmentally friendly microextractions of carbamates and dithiocarbamates

Conserved Metabolic and Evolutionary Themes in Microbial Degradation of Carbamate Pesticides

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