2022
DOI: 10.1080/1040841x.2022.2154140
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Insights into the molecular basis of c-di-GMP signalling in Pseudomonas aeruginosa

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Cited by 5 publications
(3 citation statements)
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“…Adhesion is a well-studied weapon in microbial competition 64 . Production of adhesive molecules is tightly regulated by c-di-GMP, which is in turn determined by a sophisticated network of DGCs and PDEs in response to environmental cues 20,21 . In P. aeruginosa PAO1, there are 17 different proteins with a DGC domain, 8 with a PDE domain, and 16 with both domains 65 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Adhesion is a well-studied weapon in microbial competition 64 . Production of adhesive molecules is tightly regulated by c-di-GMP, which is in turn determined by a sophisticated network of DGCs and PDEs in response to environmental cues 20,21 . In P. aeruginosa PAO1, there are 17 different proteins with a DGC domain, 8 with a PDE domain, and 16 with both domains 65 .…”
Section: Discussionmentioning
confidence: 99%
“…Due to the intrinsic resistance to antibiotics, bio lm formation makes P. aeruginosa a particularly challenging pathogen in immuno-compromised patients, especially for those with cystic brosis 17,18 . Formation and maintenance of P. aeruginosa bio lm is tightly governed by c-di-GMP, a critical secondary messenger synthesized by diguanylate cyclases (DGCs) and hydrolyzed by phosphodiesterases (PDEs) [19][20][21] .…”
Section: Introductionmentioning
confidence: 99%
“…Essentially, DEA provides a mechanism for evaluating the efciency of decision-making units (DMUs) through relative measures, leveraging mathematical programming and statistical data to sketch an efcient production frontier. Tis frontier serves as a benchmark, against which each DMU is projected and its deviation measured, indicating its relative efciency [23][24][25].…”
Section: Methodsmentioning
confidence: 99%