Insights into the physico-chemical and biological characterization of sodium lignosulfonate - silver nanosystems designed for wound management

Marinas, Ioana C.; Ignat, Leonard; Maurușa, Ignat E.; Gaboreanu, Madalina D.; Adina, Coroabă; Popa, Marcela; Chifiriuc, Mariana C.; Angheloiu, Marian; Georgescu, Mihaela; Iacobescu, Alexandra; Pircalabioru, Gratiela Gradisteanu; Stan, Miruna; Pinteala, Mariana

doi:10.1016/j.heliyon.2024.e26047

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e26047

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Insights into the physico-chemical and biological characterization of sodium lignosulfonate - silver nanosystems designed for wound management

Ioana C. Marinas,

Leonard Ignat,

Ignat E. Maurușa

et al.

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Cited by 4 publications

References 143 publications

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Bibliometric Analysis in Soil Stabilization Research: A Focus on Dust Particles and Calcium Lignosulphanate

Chiranjeevi,

Singh

2024

Natl. Acad. Sci. Lett.

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Bibliometric Analysis in Soil Stabilization Research: A Focus on Dust Particles and Calcium Lignosulphanate

Chiranjeevi,

Singh

2024

Natl. Acad. Sci. Lett.

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Green synthesis of crystalline silver nanoparticle by bio-mediated plant extract: A critical perspective analysis

Sadia,

Shishir,

Ahmed

et al. 2024

Nano-Structures & Nano-Objects

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Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil

Ilie,

Spoiala,

Chircov

et al. 2024

Antioxidants

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The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs’ surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70–75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy.

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Insights into the physico-chemical and biological characterization of sodium lignosulfonate - silver nanosystems designed for wound management

Cited by 4 publications

References 143 publications

Bibliometric Analysis in Soil Stabilization Research: A Focus on Dust Particles and Calcium Lignosulphanate

Bibliometric Analysis in Soil Stabilization Research: A Focus on Dust Particles and Calcium Lignosulphanate

Green synthesis of crystalline silver nanoparticle by bio-mediated plant extract: A critical perspective analysis

Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil

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