2020
DOI: 10.1002/ajmg.c.31833
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Insights into the regulatory molecules involved in glaucoma pathogenesis

Abstract: Glaucoma is an important cause of irreversible blindness, characterized by optic nerve anomalies. Increased intraocular pressure (IOP) and aging are major risk factors. Retinal ganglion cells and trabecular meshwork cells are certainly involved in the etiology of glaucoma. Glaucoma is usually a complex disease, and various genes and functions may contribute to its etiology. Among these may be genes that encode regulatory molecules. In this review, regulatory molecules including 18 transcription factors (TFs), … Show more

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Cited by 21 publications
(8 citation statements)
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References 286 publications
(510 reference statements)
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“…In POAG, TMCs undergo a series of molecular and morphological alterations which lead to a gradual decrease in their cell number and IOP elevation. The increase of IOP, in turn, results in other pathological alterations that further impair cell homeostasis, leading to a vicious circle [11].…”
Section: Abnormal Accumulation Of Extracellular Matrix (Ecm) Componen...mentioning
confidence: 99%
See 1 more Smart Citation
“…In POAG, TMCs undergo a series of molecular and morphological alterations which lead to a gradual decrease in their cell number and IOP elevation. The increase of IOP, in turn, results in other pathological alterations that further impair cell homeostasis, leading to a vicious circle [11].…”
Section: Abnormal Accumulation Of Extracellular Matrix (Ecm) Componen...mentioning
confidence: 99%
“…Both aberrant stiffness of TMCs and abnormal accumulation of ECM components contribute to TM fibrosis, leading to AH outflow resistance and elevated IOP [13]. During the process of POAG, the TM displays several alterations on morphologies and functions, including cell loss, increased heterogeneity of TM cellularity, increased accumulation of ECM, reduced adhesion of TMCs to ECM, formation of cross-linked actin networks, endothelial dysregulation, changes in the cytoskeleton, altered motility, reduced adhesion of TMCs to ECM, subclinical inflammation, progressive senescence and outflow impairment [11][12][13][14][15]. TM damage might trigger cross-linked proteins formation within aging tissues with malfunctioning proteolytic and ECM remodeling, as well as apoptosis and cell loss [13].…”
Section: Abnormal Accumulation Of Extracellular Matrix (Ecm) Componen...mentioning
confidence: 99%
“…MMRN1 downregulation is associated with chemoresistance in rectal cancer [ 111 ] and radiosensitivity and associated clinical outcome in gastric cancer [ 128 ]. The mmrn1 gene is associated with glaucoma [ 129 ] and bioinformatics analyses suggest mmrn1 as a hub gene in papillary thyroid cancer [ 130 ].…”
Section: Mmrn1 Differential Expression In Cancermentioning
confidence: 99%
“…LncRNAs can indirectly regulate gene expression by specifically and competitively binding to miRNAs, thereby inhibiting the effects of miRNAs on mRNAs. Changes in the expression profile of lncRNAs in the aqueous humor of glaucoma patients have been identified [ [10] , [11] , [12] , [13] ]. In addition, multiple lncRNAs are involved in the trabecular meshwork and retinal damage in glaucoma, particularly MALAT1 [ [14] , [15] , [16] ] and H19 [ 17 , 18 ], both of which regulate RGCs loss and trabecular meshwork cell damage in glaucoma via different mechanisms.…”
Section: Introductionmentioning
confidence: 99%