Insights into the removal of pharmaceutically active compounds from sewage sludge by two-stage mesophilic anaerobic digestion

Gallardo-Altamirano, M.J.; Maza-Márquez, Paula; Montemurro, Nicola; Pérez, Sandra; Rodelas, B.; Osorio, Francisco; Pozo, Clementina

doi:10.1016/j.scitotenv.2021.147869

Cited by 27 publications

(6 citation statements)

References 105 publications

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“…The most abundant order was Clostridiales in rSS (more than 20% of abundance); Bacteroidales and Synergistales in dSS (more than 30% between both) ( Figure 2 B). Similar bacterial groups were detected in sludges after mesophilic anaerobic digestion, where the phylum Bacteroidetes , Chloroflexi , Firmicutes , and Proteobacteria were predominant [ 47 ].…”

Section: Resultsmentioning

confidence: 78%

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High-Throughput Microbial Community Analyses to Establish a Natural Fungal and Bacterial Consortium from Sewage Sludge Enriched with Three Pharmaceutical Compounds

Ledezma-Villanueva

Robledo-Mahón

Gómez-Silván

et al. 2022

JoF

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Emerging and unregulated contaminants end up in soils via stabilized/composted sewage sludges, paired with possible risks associated with the development of microbial resistance to antimicrobial agents or an imbalance in the microbial communities. An enrichment experiment was performed, fortifying the sewage sludge with carbamazepine, ketoprofen and diclofenac as model compounds, with the aim to obtain strains with the capability to transform these pollutants. Culturable microorganisms were obtained at the end of the experiment. Among fungi, Cladosporium cladosporioides, Alternaria alternata and Penicillium raistrickii showed remarkable degradation rates. Population shifts in bacterial and fungal communities were also studied during the selective pressure using Illumina MiSeq. These analyses showed a predominance of Ascomycota (Dothideomycetes and Aspergillaceae) and Actinobacteria and Proteobacteria, suggesting the possibility of selecting native microorganisms to carry out bioremediation processes using tailored techniques.

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Section: Resultsmentioning

confidence: 78%

“…Thus, after the digestion and storage of sewage sludge, some ECs will still persist [ 46 ]. More recently, the increase in the retention time of the anaerobic bioreactor or the two-phase process seems to be an efficient strategy in removing several PhACs [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

High-Throughput Microbial Community Analyses to Establish a Natural Fungal and Bacterial Consortium from Sewage Sludge Enriched with Three Pharmaceutical Compounds

Ledezma-Villanueva

Robledo-Mahón

Gómez-Silván

et al. 2022

JoF

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“…In a sulfidogenic fluidized bed bioreactor used to treat acidic metal-containing water and hospital wastewater, the rate of KTP removal was only 41.9% ( Makhathini et al, 2021 ). In a separate study involving a two-stage mesophilic anaerobic digestion process (acidogenic and methanogenic, connected in series), the removal of KTP from wastewater was 53% ( Gallardo-Altamirano et al, 2021 ). Interestingly, the relative abundance of the class Clostridia ( Bacillota ) as well as the families Propionibacteriaceae ( Actinomycetota ) and Cytophagaceae ( Bacteroidota ), and the versatile methanogenic genus Methanosarcina , showed strong correlations with the presence of KTP in the system.…”

Section: Bioremoval Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

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Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being. It poses a growing threat due to its racemic mixture, enantiomers, and transformation products, which have ecotoxicological effects on various organisms, including invertebrates, vertebrates, plants, and microorganisms. Furthermore, ketoprofen is bioaccumulated and biomagnified throughout the food chain, threatening the ecosystem function. Surprisingly, despite these concerns, ketoprofen is not currently considered a priority substance. While targeted eco-pharmacovigilance for ketoprofen has been proposed, data on ketoprofen as a pharmaceutical contaminant are limited and incomplete. This review aims to provide a comprehensive summary of the most recent findings (from 2017 to March 2023) regarding the global distribution of ketoprofen in the environment, its ecotoxicity towards aquatic animals and plants, and available removal methods. Special emphasis is placed on understanding how ketoprofen affects microorganisms that play a pivotal role in Earth’s ecosystems. The review broadly covers various approaches to ketoprofen biodegradation, including whole-cell fungal and bacterial systems as well as enzyme biocatalysts. Additionally, it explores the potential of adsorption by algae and phytoremediation for removing ketoprofen. This review will be of interest to a wide range of readers, including ecologists, microbiologists, policymakers, and those concerned about pharmaceutical pollution.

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“…The extraction of pharmaceuticals from sludge was performed according to Gallardo-Altamirano et al . (2021) .…”

Section: Methodsmentioning

confidence: 99%

“…Analytes were eluted with 3 × 3 mL of EtAc:MeOH (1:1, v/v), and the resulting extracts were evaporated to dryness under a gentle stream of nitrogen. The dried extracts were reconstituted with 1 mL of H 2 O/MeOH (90:10) and filtered to 2 mL vials using 0.22 μm polytetrafluoroethylene (PTFE) syringe filters for further UHPLC-MS/MS analysis ( Gallardo-Altamirano et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Exploring the correlations between epi indicators of COVID-19 and the concentration of pharmaceutical compounds in wastewater treatment plants in Northern Portugal

Silva

Mesquita

Duarte

et al. 2023

Journal of Hazardous Materials Advances

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Insights into the removal of pharmaceutically active compounds from sewage sludge by two-stage mesophilic anaerobic digestion

Cited by 27 publications

References 105 publications

High-Throughput Microbial Community Analyses to Establish a Natural Fungal and Bacterial Consortium from Sewage Sludge Enriched with Three Pharmaceutical Compounds

High-Throughput Microbial Community Analyses to Establish a Natural Fungal and Bacterial Consortium from Sewage Sludge Enriched with Three Pharmaceutical Compounds

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Exploring the correlations between epi indicators of COVID-19 and the concentration of pharmaceutical compounds in wastewater treatment plants in Northern Portugal

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