Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets

Kciuk, Mateusz; Yahya, Esam Bashir; Mohamed, Montaha Mohamed Ibrahim; Abdulsamad, Muhanad Abdullah; Allaq, Abdulmutalib A.; Gielecińska, Adrianna; Kontek, Renata

doi:10.3390/cancers15133298

Cited by 14 publications

(2 citation statements)

References 227 publications

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“…For instance, in Alzheimer’s disease (AD), the lncRNA BACE1-AS was found to interact with BACE1, a key enzyme involved in amyloid-β formation and AD pathogenesis ( Faghihi et al, 2010 ). Additionally, the lncRNA HOTAIR was shown to modulate the expression of HOX genes by interacting with PRC2 in glioblastoma ( Kciuk et al, 2023 ; Xin et al, 2023 ).…”

Section: Mechanisms Of Lncrnas In Biological Processesmentioning

confidence: 99%

Hidden regulators: the emerging roles of lncRNAs in brain development and disease

Alammari,

Al-Hujaily,

Alshareeda

et al. 2024

Front. Neurosci.

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Long non-coding RNAs (lncRNAs) have emerged as critical players in brain development and disease. These non-coding transcripts, which once considered as “transcriptional junk,” are now known for their regulatory roles in gene expression. In brain development, lncRNAs participate in many processes, including neurogenesis, neuronal differentiation, and synaptogenesis. They employ their effect through a wide variety of transcriptional and post-transcriptional regulatory mechanisms through interactions with chromatin modifiers, transcription factors, and other regulatory molecules. Dysregulation of lncRNAs has been associated with certain brain diseases, including Alzheimer’s disease, Parkinson’s disease, cancer, and neurodevelopmental disorders. Altered expression and function of specific lncRNAs have been implicated with disrupted neuronal connectivity, impaired synaptic plasticity, and aberrant gene expression pattern, highlighting the functional importance of this subclass of brain-enriched RNAs. Moreover, lncRNAs have been identified as potential biomarkers and therapeutic targets for neurological diseases. Here, we give a comprehensive review of the existing knowledge of lncRNAs. Our aim is to provide a better understanding of the diversity of lncRNA structure and functions in brain development and disease. This holds promise for unravelling the complexity of neurodevelopmental and neurodegenerative disorders, paving the way for the development of novel biomarkers and therapeutic targets for improved diagnosis and treatment.

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Section: Mechanisms Of Lncrnas In Biological Processesmentioning

confidence: 99%

Hidden regulators: the emerging roles of lncRNAs in brain development and disease

Alammari,

Al-Hujaily,

Alshareeda

et al. 2024

Front. Neurosci.

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“…The focus on cellular RNAs, particularly miRNAs, circRNAs, and lncRNAs, has intensified, given their roles in cancer pathophysiology [11][12][13]. The intersection of sEV cargo with miRNAs has garnered significant attention for its potential in cancer biomarker research.…”

Section: Introductionmentioning

confidence: 99%

From Fluids to Forecasts: The Promise of Small Extracellular Vesicle miRNAs in Revolutionising Cancer Diagnostics

Kartik Kumar,

Venkata Sasidhar

2024

Genetics

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Small extracellular vesicle (sEV) RNAs, particularly microRNAs (miRNAs), have emerged as pivotal biomarkers for cancer diagnosis and prognosis. Encapsulated within sEVs, these miRNAs reflect specific cellular characteristics and disease states, offering a window into cancers’ molecular underpinnings. Notably, miRNAs, such as miR-7977, miR-98-3p, miR-620, and miR-17-5p in lung cancer and miR-373, miR-1246, miR-223-3p, and miR-21 in breast cancer, have been identified in sEVs extracted from various bodily fluids, including blood, urine, and saliva. Their remarkable stability and ease of isolation make them prime targets for non-invasive cancer detection strategies. The fold change of these miRNAs is intricately linked with cancer progression, metastasis, and therapeutic responses, underscoring their potential as diagnostic and prognostic markers. Traditional detection methods like quantitative reverse transcription-polymerase chain reaction (qRT-PCR) have been foundational; however, recent biosensing technologies, such as nanopore sequencing and microfluidic chips, offer enhanced sensitivity and specificity for detecting miRNAs in clinical samples. These innovative approaches refine the detection process and pave the way for real-time monitoring of disease progression and treatment efficacy. Overall, the collective evidence positions sEV miRNAs as robust indicators for cancer, signalling a shift towards personalised cancer care that emphasises early detection and tailored treatment strategies.

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Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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Cancer stands as a leading cause of global mortality, with chemotherapy being a pivotal treatment approach, either alone or in conjunction with other therapies. The primary goal these therapies is to inhibit the growth of cancer cells specifically, while minimizing harm to healthy dividing cells. Conventional treatments have been hampered by their side effects, often causing severe discomfort to patients. Researchers have been exploring innovative approaches to target cancer cells selectively. In this context, biopolymer‐based aerogels emerge as innovative platforms, showcasing unique properties that respond intelligently to diverse stimuli, including temperature, pH variations, magnetic fields, and redox potential. This responsiveness enables precise control over the release of anticancer drugs, enhancing therapeutic outcomes. The significance of these aerogels lies in their ability to offer targeted drug delivery with increased efficacy, biocompatibility, and a high drug payload. In this comprehensive review, we discuss the role of biopolymer‐based aerogels as an emerging functionalized platforms in anticancer drug delivery. The review addresses the unique properties of biopolymer‐based aerogels showing their smart behavior in responding to different stimuli including temperature, pH, magnetic and redox potential to control anticancer drug release. Finally, the review discusses the application of different biopolymer‐based aerogel in delivering different anticancer drugs and also discusses the potential of these platforms in gene delivery applications. This article is protected by copyright. All rights reserved

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Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets

Cited by 14 publications

References 227 publications

Hidden regulators: the emerging roles of lncRNAs in brain development and disease

Hidden regulators: the emerging roles of lncRNAs in brain development and disease

From Fluids to Forecasts: The Promise of Small Extracellular Vesicle miRNAs in Revolutionising Cancer Diagnostics

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

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