2022
DOI: 10.1016/j.semcancer.2021.05.031
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Insights into the role of complement regulatory proteins in HPV mediated cervical carcinogenesis

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Cited by 10 publications
(7 citation statements)
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“…Cervical cancer exhibits a high propensity for invasion and metastasis, leading to poor prognosis. The 5-year survival rate of patients with cervical cancer ranges from 30 to 60% ( Khan et al, 2021 ). Univariate analysis demonstrated that pathologic_stage ( p = 0.000426), T_stage ( p = 9.53e−05), N_stage ( p = 0.00637), M_stage ( p = 0.0225), and lymph_node involvement ( p = 1.39e−05) were independent prognostic factors for CC patients.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Cervical cancer exhibits a high propensity for invasion and metastasis, leading to poor prognosis. The 5-year survival rate of patients with cervical cancer ranges from 30 to 60% ( Khan et al, 2021 ). Univariate analysis demonstrated that pathologic_stage ( p = 0.000426), T_stage ( p = 9.53e−05), N_stage ( p = 0.00637), M_stage ( p = 0.0225), and lymph_node involvement ( p = 1.39e−05) were independent prognostic factors for CC patients.…”
Section: Resultsmentioning
confidence: 99%
“…Globally, cervical cancer (CC) is the second most frequent cause of cancer-related deaths in women ( Khan et al, 2021 ). Developing countries have a high incidence of CC ( Wang et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…The virus can stimulate the complement system cascade, which is fully activated only during the inflammatory process, opsonization, phagocytosis, and pathogen elimination. This process activates the adaptive immune response and promotes cancer development ( 17 ) . In contrast to HPV-positive cervical cancer, people with HPV-negative cervical carcinoma are discovered more frequently at an advanced stage and frequently have non-squamous histology.…”
Section: Discussionmentioning
confidence: 99%
“…The activation of the complement system is part of the immune system, which also affects the TME and stimulates the proliferation of macrophages and neutrophils and suppresses myeloid cells, thereby stimulating the release of pro-inflammatory cytokines, which increase neutrophil proliferation and suppress lymphocytes, T-cells, and NK cells. Therefore, elevated blood NLR is a marker that predisposes tumors to proliferation and metastasis by inhibiting apoptosis, promoting angiogenesis, and causing DNA damage ( 17 ) . An earlier study also discovered a relationship between NLR and carcinoma metastasis and higher MASP-2 levels in unsurvived patients as opposed to those who survived ( 7 ) .…”
Section: Discussionmentioning
confidence: 99%
“…Several epidemiological risk factors are associated with the pathology of cervical cancer. Most prominently, Human Papillomavirus (HPV) infection is the principal causative agent with about 80% of cervical cancers attributable to the two high risk HPV types; 16 and 18 (6,7,8). Other crucial factors include early age at marriage and first childbirth, multiparity, having multiple sex partners, smoking, lack of awareness of cervical cancer, along with inadequate menstrual hygiene practices (9-10-13).…”
Section: Introductionmentioning
confidence: 99%