“…According to the level of thermal stress, diverse conformations of Bcl-2 are obtained. In particular, simulations at temperatures less than or equal to 500 K provide possible structures related to active or inactive forms, whereas at temperatures above 500 K, an unfolding process could be proposed (Chen, Li, & Ma, 2009;Rosas-Trigueros, Correa-Basurto, Benítez-Cardoza, & Zamorano-Carrillo, 2011). Concerning functionality, snapshots show that the conformational movements led to the interaction between the Bcl-2 FLD and the protein core (Figure 4), which might be related to a regulation of Bcl-2 phosphorylation, caspase cleavage, and the interaction of Bcl-2 with pro-apoptotic proteins (Blagosklonny, 2001;Deng et al, 2006;Haldar et al, 1998;Huang et al, 1998;Kazi et al, 2011;Kirsch et al, 1999;Lin et al, 2004;Reed et al, 1996;Ruvolo et al, 2001;Srivastava et al, 1999).…”