2018
DOI: 10.1039/c8nr07110a
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Insights into the structure and nanomechanics of a quatsome membrane by force spectroscopy measurements and molecular simulations

Abstract: Quatsomes (QS) membrane structure and nanomechanics. Promising candidates for drug delivery based on deformable vesicles.

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Cited by 13 publications
(20 citation statements)
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“…It has been applied to characterize the stiffness of DNA origami, 155 protein complexes, 156 protein-coated lipid nanotubes 157 or liposomes. 158 FV maps have recorded the changes in the mechanical properties of a virus. This has led to a more comprehensive characterization of the steps in virus maturation.…”
Section: Force-volume Applicationsmentioning
confidence: 99%
“…It has been applied to characterize the stiffness of DNA origami, 155 protein complexes, 156 protein-coated lipid nanotubes 157 or liposomes. 158 FV maps have recorded the changes in the mechanical properties of a virus. This has led to a more comprehensive characterization of the steps in virus maturation.…”
Section: Force-volume Applicationsmentioning
confidence: 99%
“…Their described desirable qualities and their inherent antimicrobial activity make them suitable candidates for antibiotic delivery [ 13 , 23 ]. However, so far studies in the literature have reported on quatsomes with the aim of improving the toxicity profile of cationic compounds employed to formulate them, understanding the physical–chemical properties of their membrane [ 22 , 24 ] and identifying their potential as antibiofilm agents [ 13 , 24 ] due to their cationicity.…”
Section: Introductionmentioning
confidence: 99%
“…The reported quatsomes have mostly been prepared from cationic quaternary surfactants available in the market. Most of these surfactants are toxic to various cells in the body and due to that, their systemic toxicity application is limited [ 24 , 25 , 26 ]. The antibacterial activity of the quaternary ammonium compounds (QAC) has been attributed to a higher positive charge density of the biomaterials [ 27 ].…”
Section: Introductionmentioning
confidence: 99%
“…46 In a recent work we have reported that quatsomes non-liposomal lipid nanovesicles, although having also a high cholesterol content, are flexible nanovesicles, formed by a bilayer membrane with comparable structural properties to fluid-like lipid bilayers. 47 These differences on the membrane phase state between liposome and quatsomes might cause a different type of enzyme-nanovesicle association and explain the different enzyme activity under both different type of encapsulation patterns. It has been reported that the way proteins interact with lipid membranes depend not only on the surface charge of the membrane but also on the phase state.…”
Section: The Specific Enzymatic Activity Of Gla Is Increased In Hlp-g...mentioning
confidence: 99%