Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Li, Dan; Lin, Qinlu; Luo, Feijun; Wang, Hanqing

doi:10.3390/foods13010145

Cited by 4 publications

(1 citation statement)

References 136 publications

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“…It could be beneficial considering the high energy requirements of puppies just after birth, their limited energy reserves and their immature thermoregulation system (95). Interestingly, in bitches, plasma N-acetylneuraminate (also known as sialic acid) was identified as a discriminant metabolite, suggesting a modulation of amino-sugar metabolism (96,97). Sialic acid has been described as increasing in gestating women, being largely involved in the milk oligosaccharides synthesis, and crossing the placenta to participate to in utero body growth and brain development (98).…”

Section: Group Comparisonmentioning

confidence: 99%

The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies

Garrigues,

Mugnier,

Chastant

et al. 2024

Front. Nutr.

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Time around parturition is a stressful period for both bitches and their puppies. The use of probiotics has been proposed, e.g., in pigs, to improve health status of sows, their reproductive performances and in turn, the health and performance of their progeny. The objective of the present study was to evaluate the impact, on both dams and puppies, of a supplementation of bitches with the live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 (SB-1079) during the second part of the gestation and the lactation period. A total of 36 bitches of medium and large-sized breeds were enrolled. They were divided into two groups, one of which received 1.3 × 109 colony forming units of live yeast per day. At dam’s level, SB-1079 yeast shaped a different microbiota structure between the two groups just after whelping, impacted alpha diversity and some plasma metabolites related to energy metabolism. Regarding reproductive performances, SB-1079 improved gross energy of the colostrum (1.4 vs. 1.2 kcal of ME/g) as well as the concentration of protein in milk at Day 7 after parturition (10.4 vs. 7.6%). SB-1079 also reduced the odds of having low birth weight in the litter. At puppy’s level, a modulation of immunometabolic phenotype is suggested by the observation of increased growth rates during the early pediatric period (i.e., between 21 and 56 days of life, 225 vs. 190%) and a decrease of the IL-8:IL-10 ratio after vaccination against rabies (4.2 vs. 16.9). Our findings suggest that SB-1079 supplementation during gestation and lactation has the potential to enhance health of bitches and in turn health of puppies through maternal programming.

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Section: Group Comparisonmentioning

confidence: 99%

The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies

Garrigues,

Mugnier,

Chastant

et al. 2024

Front. Nutr.

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Sialic acid metabolism of oral bacteria and its potential role in colorectal cancer and Alzheimer's disease

Zhu,

Li,

et al. 2024

Carbohydrate Research

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Effect of Edible Bird’s Nest on Protecting against Cognitive Deficit and Ameliorating Beta‐Amyloid in Hippocampal Rats’ Model of Cerebral Ischemia

Sirinupong,

Chansuwan,

Kaewkaen

2024

Journal of Food Biochemistry

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Cerebral ischemia has been identified as the primary cause of global mortality, but there is currently no effective therapy for treating this condition. Consequently, the search for novel neuroprotective agents that can guard against stroke remains essential. Recent research has demonstrated the importance of alternative treatments in the pathology of cerebral ischemia leading to vascular dementia. The purpose of this study was to determine the effect of neurocognitive behavior and beta‐amyloid markers in terms of the neuroprotective effects of Edible Bird’s Nest (EBN). Male adult Wistar rats were orally administered EBN at concentrations of 10, 50, and 100 mg/kg for 2 weeks prior to and 3 weeks after middle cerebral artery occlusion surgery to mimic vascular dementia. The rodents were then classified based on their neurological score, beta‐amyloid accumulation, volume of cerebral infarction, and acetylcholinesterase activity. We assessed the animals’ spatial memory and administered the Morris water maze and radial arm maze tests. We found that EBN substantially decreased beta‐amyloid in the hippocampus, decreased acetylcholinesterase activity, and enhanced the animals’ neurological scores and spatial memory. We conclude that EBN contains potential substances that promote learning and memory pathways. However, additional research is still necessary to confirm these findings.

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Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Cited by 4 publications

References 136 publications

The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies

The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies

Sialic acid metabolism of oral bacteria and its potential role in colorectal cancer and Alzheimer's disease

Effect of Edible Bird’s Nest on Protecting against Cognitive Deficit and Ameliorating Beta‐Amyloid in Hippocampal Rats’ Model of Cerebral Ischemia

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